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Special notice

Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)

DARPA-SN-26-67

Defense Advanced Research Projects Agency, Def Advanced Research Projects Agcy. Research and Development in Biotechnology (except Nanobiotechnology).

18 open like this View on SAM.gov Markdown

Response deadline

June 24, 2026

Closed 130 days ago. Posted May 18, 2026, first published May 6, 2026. Scheduled to archive June 25, 2026.

Get the next one like this from Defense Advanced Research Projects Agency by email, the day it is posted.Find my opportunities

This one closed in 2026

18 like it are open now in research and development in biotechnology (except nanobiotechnology)

All 18 open in research and development in biotechnology (except nanobiotechnology)

Description

As published on SAM.gov.

UPDATE: The purpose of Amendment 1 to DARPA-SN-26-67, the DNA-Protein Epigenetic Chemistry Engineering (D-PECHE) Special Notice (SN), is to clarify submission instructions and deadlines.

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to demonstrate proof-of-concept for novel mechanisms for writing and erasing epigenetic base modifications in DNA. Mechanisms capable of modifying the epigenome offer new opportunities to control DNA-protein interactions and to study the functions and applications of rare or novel epigenetic modifications. This research opportunity will result in demonstrations of novel technologies to modify nucleic acids in vitro.

Attachments

Files listed on SAM.gov. The ones we hold a copy of download from here; the rest open SAM's download, which needs no account.

Publications

Every notice SAM.gov issued under this solicitation number, oldest first. Each is a separate record on SAM.

  1. May 6, 2026

    Special notice

    Due June 24, 2026. SAM.gov, notice 554a1250e7e44f8f8f9797eb40b5031b

    2 revisions on SAM
    • May 18, 2026: publish, special notice
    • May 6, 2026: publish, special notice

  2. May 18, 2026

    Special notice

    Due June 24, 2026. SAM.gov, notice 553632b7e7fd49a7884a1c32f8a611c5

    2 revisions on SAM
    • May 18, 2026: publish, special notice
    • May 6, 2026: publish, special notice

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