# Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)

Canonical: https://abierto.us/opportunities/darpasn2667

- Solicitation number: DARPA-SN-26-67
- Notice type: Special notice
- Status: Closed. Deadline was June 24, 2026
- Department: Department of Defense
- Agency: Defense Advanced Research Projects Agency
- Contracting office: Def Advanced Research Projects Agcy (HR0011)
- NAICS: 541714 Research and Development in Biotechnology (except Nanobiotechnology)
- Product or service code: AC11 National Defense R&D Services; Department Of Defense - Military; Basic Research
- First posted: May 6, 2026
- Last posted: May 18, 2026
- SAM.gov: https://sam.gov/workspace/contract/opp/553632b7e7fd49a7884a1c32f8a611c5/view

## Description

**UPDATE:** The purpose of Amendment 1 to DARPA-SN-26-67, the DNA-Protein Epigenetic Chemistry Engineering (D-PECHE) Special Notice (SN), is to clarify submission instructions and deadlines. The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to demonstrate proof-of-concept for novel mechanisms for writing and erasing epigenetic base modifications in DNA. Mechanisms capable of modifying the epigenome offer new opportunities to control DNA-protein interactions and to study the functions and applications of rare or novel epigenetic modifications. This research opportunity will result in demonstrations of novel technologies to modify nucleic acids in vitro.

## Publications

- May 6, 2026: Special notice, due June 24, 2026. Notice 554a1250e7e44f8f8f9797eb40b5031b. https://sam.gov/workspace/contract/opp/554a1250e7e44f8f8f9797eb40b5031b/view
- May 18, 2026: Special notice, due June 24, 2026. Notice 553632b7e7fd49a7884a1c32f8a611c5. https://sam.gov/workspace/contract/opp/553632b7e7fd49a7884a1c32f8a611c5/view

## Points of contact

- Dr. Aric Lu, DARPA/BTO, D-PECHE@darpa.mil

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/darpasn2667.