{"canonical":"https://abierto.us/opportunities/darpasn2667","key":"DARPASN2667","url":"https://abierto.us/opportunities/darpasn2667","title":"Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)","solicitation_number":"DARPA-SN-26-67","notice_type":"s","open":false,"response_deadline":"2026-06-24","first_posted":"2026-05-06","last_posted":"2026-05-18","department":"DEPT OF DEFENSE","subagency":"DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)","office":"DEF ADVANCED RESEARCH PROJECTS AGCY","naics":"541714","psc":"AC11","set_aside":null,"place_state":null,"place_county":null,"place_county_name":null,"place_city":null,"place_city_name":null,"winner":null,"award_amount":null,"publications":[{"notice_id":"554a1250e7e44f8f8f9797eb40b5031b","title":"Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)","solicitation_number":"DARPA-SN-26-67","notice_type":"s","base_type":"s","posted":"2026-05-06","posted_at":null,"due_at":null,"due_date":"2026-06-24","cancelled":null,"archived":null,"archive_date":"2026-06-25","award_number":null,"awardee_name":null,"amount":null,"link_sam":"https://sam.gov/workspace/contract/opp/554a1250e7e44f8f8f9797eb40b5031b/view","enriched":false,"history":[]},{"notice_id":"553632b7e7fd49a7884a1c32f8a611c5","title":"Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)","solicitation_number":"DARPA-SN-26-67","notice_type":"s","base_type":"s","posted":"2026-05-18","posted_at":null,"due_at":null,"due_date":"2026-06-24","cancelled":null,"archived":null,"archive_date":"2026-06-25","award_number":null,"awardee_name":null,"amount":null,"link_sam":"https://sam.gov/workspace/contract/opp/553632b7e7fd49a7884a1c32f8a611c5/view","enriched":false,"history":[]}],"latest_notice_id":"553632b7e7fd49a7884a1c32f8a611c5","first_type":"s","notices":[{"dates":{"posted":"2026-05-06","response_deadline":{"raw":"2026-06-24T16:00:00","date":"2026-06-24","time":"16:00:00"}},"links":{"sam":"https://sam.gov/workspace/contract/opp/554a1250e7e44f8f8f9797eb40b5031b/view"},"naics":{"codes":["541714"],"primary":"541714"},"title":"Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)","agency":{"office":{"code":"HR0011","name":"DEF ADVANCED RESEARCH PROJECTS AGCY"},"subtier":{"code":"97AE","name":"DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)"},"department":{"code":"097","name":"DEPT OF DEFENSE"},"office_address":{"zip":"222032114","city":"ARLINGTON","state":"VA","country":"USA"},"organization_type":"OFFICE"},"status":{"active":false,"archive_date":"2026-06-25","archive_type":"auto_custom"},"contacts":[{"name":"Dr. Aric Lu, DARPA/BTO","role":"primary","email":"D-PECHE@darpa.mil"}],"base_type":{"code":"s","label":"Special Notice"},"notice_id":"554a1250e7e44f8f8f9797eb40b5031b","provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/Archived%20Data/FY2026_archived_opportunities.csv","etag":"\"d9374b90a938e9923d910594731b7b57-106\"","fetched_at":"2026-09-16T16:22:53.920682Z","row_sha256":"fcfc03616db879e427ca12ab0fcdbbfea3fff5c1be983e07ebef194d91ceba95","last_modified":"2026-09-13T14:50:39Z"},"updated_at":"2026-09-16T16:22:53.920682Z","first_seen_at":"2026-09-16T16:22:53.920682Z"},"description":{"text":"The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to demonstrate proof-of-concept for novel mechanisms for writing and erasing epigenetic base modifications in DNA. Mechanisms capable of modifying the epigenome offer new opportunities to control DNA-protein interactions and to study the functions and applications of rare or novel epigenetic modifications. This research opportunity will result in demonstrations of novel technologies to modify nucleic acids in vitro.","origin":"extract"},"notice_type":{"code":"s","label":"Special Notice"},"schema_version":1,"solicitation_number":"DARPA-SN-26-67","product_service_code":"AC11"},{"dates":{"posted":"2026-05-18","response_deadline":{"raw":"2026-06-24T16:00:00","date":"2026-06-24","time":"16:00:00"}},"links":{"sam":"https://sam.gov/workspace/contract/opp/553632b7e7fd49a7884a1c32f8a611c5/view"},"naics":{"codes":["541714"],"primary":"541714"},"title":"Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)","agency":{"office":{"code":"HR0011","name":"DEF ADVANCED RESEARCH PROJECTS AGCY"},"subtier":{"code":"97AE","name":"DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)"},"department":{"code":"097","name":"DEPT OF DEFENSE"},"office_address":{"zip":"222032114","city":"ARLINGTON","state":"VA","country":"USA"},"organization_type":"OFFICE"},"status":{"active":false,"archive_date":"2026-06-25","archive_type":"auto_custom"},"contacts":[{"name":"Dr. Aric Lu, DARPA/BTO","role":"primary","email":"D-PECHE@darpa.mil"}],"base_type":{"code":"s","label":"Special Notice"},"notice_id":"553632b7e7fd49a7884a1c32f8a611c5","provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/Archived%20Data/FY2026_archived_opportunities.csv","etag":"\"d9374b90a938e9923d910594731b7b57-106\"","fetched_at":"2026-09-16T16:22:53.920682Z","row_sha256":"95bb12d94a0403af3537fca99b3f5fcbcecc07ef18037ee575665f5304e6e624","last_modified":"2026-09-13T14:50:39Z"},"updated_at":"2026-09-16T16:22:53.920682Z","first_seen_at":"2026-09-16T16:22:53.920682Z"},"description":{"text":"UPDATE: The purpose of Amendment 1 to DARPA-SN-26-67, the DNA-Protein Epigenetic Chemistry Engineering (D-PECHE) Special Notice (SN), is to clarify submission instructions and deadlines. The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to demonstrate proof-of-concept for novel mechanisms for writing and erasing epigenetic base modifications in DNA. Mechanisms capable of modifying the epigenome offer new opportunities to control DNA-protein interactions and to study the functions and applications of rare or novel epigenetic modifications. This research opportunity will result in demonstrations of novel technologies to modify nucleic acids in vitro.","origin":"extract"},"notice_type":{"code":"s","label":"Special Notice"},"schema_version":1,"solicitation_number":"DARPA-SN-26-67","product_service_code":"AC11"}],"due_at":null,"due_date":"2026-06-24","closes_at":"2026-06-25T00:00:00Z","awardable":false,"dept_key":"d-097","dept_name":"DEPT OF DEFENSE","sub_key":"s-97AE","sub_name":"DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)","office_key":"o-HR0011","office_name":"DEF ADVANCED RESEARCH PROJECTS AGCY","state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z","principal_notice_id":"553632b7e7fd49a7884a1c32f8a611c5","description":{"text":"UPDATE: The purpose of Amendment 1 to DARPA-SN-26-67, the DNA-Protein Epigenetic Chemistry Engineering (D-PECHE) Special Notice (SN), is to clarify submission instructions and deadlines. The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to demonstrate proof-of-concept for novel mechanisms for writing and erasing epigenetic base modifications in DNA. Mechanisms capable of modifying the epigenome offer new opportunities to control DNA-protein interactions and to study the functions and applications of rare or novel epigenetic modifications. This research opportunity will result in demonstrations of novel technologies to modify nucleic acids in vitro.","html":null,"origin":"extract"},"contacts":[{"name":"Dr. Aric Lu, DARPA/BTO","role":"primary","email":"D-PECHE@darpa.mil"}],"place_of_performance":null,"office_address":{"zip":"222032114","city":"ARLINGTON","state":"VA","country":"USA"},"naics_codes":["541714"],"award":null,"attachments":[],"awards":[],"related":[{"key":"DARPAPS26127","latest_notice_id":"8b8a67ca341440198bb3e5d8c4786454","title":"Perrseus","solicitation_number":"DARPA-PS-26-127","notice_type":"o","first_type":"o","first_posted":"2026-07-15","last_posted":"2026-09-14","notices":15,"due_at":null,"due_date":"2026-09-23","closes_at":"2026-09-24T00:00:00Z","awardable":true,"open":true,"dept_key":"d-097","dept_name":"DEPT OF DEFENSE","sub_key":"s-97AE","sub_name":"DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)","office_key":"o-HR0011","office_name":"DEF ADVANCED RESEARCH PROJECTS AGCY","naics":"541715","psc":"AC12","set_aside":null,"state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z"},{"key":"HR001126S0003","latest_notice_id":"8d403582edfd409795560247e8d229b7","title":"Biological Technologies","solicitation_number":"HR001126S0003","notice_type":"o","first_type":"o","first_posted":"2025-10-01","last_posted":"2025-10-01","notices":1,"due_at":null,"due_date":"2026-09-30","closes_at":"2026-10-01T00:00:00Z","awardable":true,"open":true,"dept_key":"d-097","dept_name":"DEPT OF DEFENSE","sub_key":"s-97AE","sub_name":"DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)","office_key":"o-HR0011","office_name":"DEF ADVANCED RESEARCH PROJECTS AGCY","naics":"541714","psc":"AC11","set_aside":null,"state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z"},{"key":"HR001126S0016","latest_notice_id":"5b497934e0474b72bbf7e03d8babb571","title":"Precision Inertial Navigation & Positioning On an Integrated Tesseract (PINPOINT)","solicitation_number":"HR001126S0016","notice_type":"o","first_type":"o","first_posted":"2026-08-06","last_posted":"2026-09-10","notices":3,"due_at":null,"due_date":"2026-10-02","closes_at":"2026-10-03T00:00:00Z","awardable":true,"open":true,"dept_key":"d-097","dept_name":"DEPT OF DEFENSE","sub_key":"s-97AE","sub_name":"DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)","office_key":"o-HR0011","office_name":"DEF ADVANCED RESEARCH PROJECTS AGCY","naics":"541715","psc":"AC12","set_aside":null,"state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z"},{"key":"DARPAPA250706","latest_notice_id":"3ac25ac710fb438e8d25d99783cee845","title":"Selective Harnessing of Intrinsic Neuroplasticity Engineering (SHINE)","solicitation_number":"DARPA-PA-25-07-06","notice_type":"o","first_type":"o","first_posted":"2026-08-28","last_posted":"2026-09-03","notices":2,"due_at":null,"due_date":"2026-10-09","closes_at":"2026-10-10T00:00:00Z","awardable":true,"open":true,"dept_key":"d-097","dept_name":"DEPT OF DEFENSE","sub_key":"s-97AE","sub_name":"DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)","office_key":"o-HR0011","office_name":"DEF ADVANCED RESEARCH PROJECTS AGCY","naics":"541715","psc":"AC11","set_aside":null,"state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z"},{"key":"DARPAPA250704","latest_notice_id":"f0e3e0d303254053922d9b2c7a67e878","title":"Resilient","solicitation_number":"DARPA-PA-25-07-04","notice_type":"o","first_type":"o","first_posted":"2026-08-20","last_posted":"2026-09-04","notices":3,"due_at":null,"due_date":"2026-10-19","closes_at":"2026-10-20T00:00:00Z","awardable":true,"open":true,"dept_key":"d-097","dept_name":"DEPT OF DEFENSE","sub_key":"s-97AE","sub_name":"DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)","office_key":"o-HR0011","office_name":"DEF ADVANCED RESEARCH PROJECTS AGCY","naics":"541715","psc":"AC12","set_aside":null,"state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z"}]}