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Combined synopsis and solicitation

Cap-dependent endonuclease inhibitors (CENis) - NHRC

N0018926QB059

Department of the Navy, NAVSUP FLT Log CTR Norfolk. Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology).

127 open like this View on SAM.gov Markdown

Response deadline

May 28, 2026 at 5:00 PM EDT

Closed 157 days ago. Posted May 26, 2026, first published May 15, 2026. Scheduled to archive June 12, 2026.

Get the next one like this from Department of the Navy by email, the day it is posted.Find my opportunities

This one closed in 2026

127 like it are open now in research and development in the physical, engineering, and life sciences (except nanotechnology and biotechnology)

All 127 open in research and development in the physical, engineering, and life sciences (except nanotechnology and biotechnology)

Description

As published on SAM.gov.

The preclinical development of Cap-dependent endonuclease inhibitors (CENi), a class of small molecules, as broad-spectrum antiviral therapeutics. The scope of this project includes all activities required to select lead CENi candidates, including in vitro and in vivo efficacy studies and characterization and optimization of lead compounds. This includes Research Support expertise regarding the preclinical development of cap-dependent endonuclease inhibitors (CENis) with viruses that require biosafety level 4 (BSL-4) containment to support the Naval Medical Research Command in Fort Detrick, MD. This work will be performed over a 36-month period.

Attachments

Files listed on SAM.gov. The ones we hold a copy of download from here; the rest open SAM's download, which needs no account.

Publications

Every notice SAM.gov issued under this solicitation number, oldest first. Each is a separate record on SAM.

  1. May 15, 2026

    Combined synopsis and solicitation

    Due May 25, 2026 at 5:00 PM EDT. SAM.gov, notice 7ca6661dd9ec4edb86296ad3bc28a805

    2 revisions on SAM
    • May 26, 2026: publish, combined synopsis and solicitation
    • May 15, 2026: publish, combined synopsis and solicitation

  2. May 26, 2026

    Combined synopsis and solicitation

    Due May 28, 2026 at 5:00 PM EDT. SAM.gov, notice 9c47ad00291343ad8b22f15cf93fe208

    2 revisions on SAM
    • May 26, 2026: publish, combined synopsis and solicitation
    • May 15, 2026: publish, combined synopsis and solicitation

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