Combined synopsis and solicitation
Cap-dependent endonuclease inhibitors (CENis) - NHRC
N0018926QB059
Department of the Navy, NAVSUP FLT Log CTR Norfolk. Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology).
Response deadline
May 28, 2026 at 5:00 PM EDT
Closed 111 days ago. Posted May 26, 2026, first published May 15, 2026. Scheduled to archive June 12, 2026.
Description
As published on SAM.gov.
The preclinical development of Cap-dependent endonuclease inhibitors (CENi), a class of small molecules, as broad-spectrum antiviral therapeutics. The scope of this project includes all activities required to select lead CENi candidates, including in vitro and in vivo efficacy studies and characterization and optimization of lead compounds. This includes Research Support expertise regarding the preclinical development of cap-dependent endonuclease inhibitors (CENis) with viruses that require biosafety level 4 (BSL-4) containment to support the Naval Medical Research Command in Fort Detrick, MD. This work will be performed over a 36-month period.
Publications
Every notice SAM.gov issued under this solicitation number, oldest first. Each is a separate record on SAM.
Points of contact
- Brian Kinkadebrian.m.kinkade.civ@us.navy.mil7712292412
- Jacob Gephartjacob.n.gephart.civ@us.navy.mil7712292712
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