# Cap-dependent endonuclease inhibitors (CENis) - NHRC

Canonical: https://abierto.us/opportunities/n0018926qb059

- Solicitation number: N0018926QB059
- Notice type: Combined synopsis and solicitation
- Status: Closed. Deadline was May 28, 2026 at 5:00 PM EDT
- Department: Department of the Navy
- Agency: Department of the Navy
- Contracting office: NAVSUP FLT Log CTR Norfolk (N00189)
- NAICS: 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Product or service code: AN42 Health R&D Services; Health Care - Other; Applied Research
- Place of performance: Galveston, Texas
- County: Galveston County (FIPS 48167). https://abierto.us/counties/galveston-county-tx-48167
- City: Galveston. https://abierto.us/cities/galveston-tx-4828068
- First posted: May 15, 2026
- Last posted: May 26, 2026
- SAM.gov: https://sam.gov/workspace/contract/opp/9c47ad00291343ad8b22f15cf93fe208/view

## Description

The preclinical development of Cap-dependent endonuclease inhibitors (CENi), a class of small molecules, as broad-spectrum antiviral therapeutics. The scope of this project includes all activities required to select lead CENi candidates, including in vitro and in vivo efficacy studies and characterization and optimization of lead compounds. This includes Research Support expertise regarding the preclinical development of cap-dependent endonuclease inhibitors (CENis) with viruses that require biosafety level 4 (BSL-4) containment to support the Naval Medical Research Command in Fort Detrick, MD. This work will be performed over a 36-month period.

## Publications

- May 15, 2026: Combined synopsis and solicitation, due May 25, 2026 at 5:00 PM EDT. Notice 7ca6661dd9ec4edb86296ad3bc28a805. https://sam.gov/workspace/contract/opp/7ca6661dd9ec4edb86296ad3bc28a805/view
- May 26, 2026: Combined synopsis and solicitation, due May 28, 2026 at 5:00 PM EDT. Notice 9c47ad00291343ad8b22f15cf93fe208. https://sam.gov/workspace/contract/opp/9c47ad00291343ad8b22f15cf93fe208/view

## Points of contact

- Brian Kinkade, brian.m.kinkade.civ@us.navy.mil, 7712292412
- Jacob Gephart, jacob.n.gephart.civ@us.navy.mil, 7712292712

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/n0018926qb059.