BARDA DRIVe EZ-BAA (EZBAA - 22-100-SOL-00003)

This announcement serves as a reissuance of the BARDA DRIVe EZ-BAA, now known as EZ-BAA-22-100-SOL-00003. This announcement hereby supersedes and replaces prior iterations of the BARDA DRIVe EZ-BAA (e.g. BAA-20-100-SOL-0002). Please reference the attached announcement and applicable amendments for specifics. Additionally, please visit https://drive.hhs.gov/.

Amendment 001: This amendment to the EZBAA hereby opens the following research areas of interest ("AOI"). Please review the amendment for details of each AOI, including closing dates:

AOI #15:

ReDIRECT AOI #16:

Lab at Home AOI #17:

Digital MCMs AOI #18:

Host-Directed Therapeutics AOI #19:

Healing Lungs AOI #20:

DRIVe Forward AOI #21:

Vaccines on Demand AOI #22:

ReBooT AOI #23: Host-Based Diagnostics

11/8/22 - Please see Amendment 002 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Adding the the following Area of Interest (AOI):

AOI #24: REPAIR 2. Clarifying an adminstrative error.

11/14/22 - Please see Amendment 003 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Revising the following Area of Interest (AOI):

AOI #19: Healing Lungs

12/15/22 - Please see Amendment 004 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Updating the closing date for the following Area of Interest (AOI):

AOI #21: Vaccines on Demand

1/11/23 - Please see Amendment 005 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Pausing the following Area of Interest (AOI) by establishing a new closing date of February 15, 2023 at 12:00PM ET:

AOI #15: ReDIRECT

2/1/23 - Please see Amendment 006 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Updating the closing date for the following Area of Interest (AOI):

AOI #19: Healing Lungs 2. Updating the closing date for the following Area of Interest (AOI):

AOI #17: Digital MCMs 3. Updating the closing date for the following Area of Interest (AOI):

AOI #16: Lab at Home 4. Revising the following Area of Interest (AOI):

AOI #16: Lab at Home

2/3/23 - Please see Amendment 007 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Updating the closing date for the following Area of Interest (AOI):

AOI #24: REPAIR

5/1/23 - Please see Amendment 008 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Adding the following Area of Interest (AOI):

AOI #25: FASTx 2. Updating the language in Section III (F) of the Easy Broad Agency Announcement titled “Plus (+) Phase”.

5/18/23 - Please see Amendment 009 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Reopening the following Area of Interest (AOI), which is reopened to support project Next Gen:

AOI #21: Vaccines on Demand

5/25/23 - Please see Amendment 010 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Revising the following Area of Interest (AOI):

AOI #24: REPAIR 2. Updating the closing date for the following Area of Interest (AOI):

AOI #24: REPAIR

6/27/23 - Please see Amendment 011 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Closing the following Area of Interest (AOI):

AOI #18: Host-Directed Therapeutics 2. Closing the following Area of Interest (AOI):

AOI #23: Host-Based Diagnostics 3. Updating the closing date for the following Area of Interest (AOI):

AOI #19: Healing Lungs

9/13/23 - Please see Amendment 012 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Updating the closing date for the following Area of Interest (AOI):

AOI #16: Lab at Home 2. Updating the closing date for the following Area of Interest (AOI):

AOI #17: Digital MCMs 3. Updating the closing date for the following Area of Interest (AOI):

AOI #19: Healing Lungs 4. Revising the following Area of Interest (AOI): AOI #16 Lab at Home 5. Adding the following Area of Interest (AOI):

AOI #26: Agnostic Diagnostic

9/14/23 - Please see Amendment 013 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Pausing the following Area of Interest (AOI):

AOI #20: DRIVe Forward

9/26/23 - Please see Amendment 014 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Pausing the following Area of Interest (AOI):

AOI #21: Vaccines on Demand

10/26/23 - Please see Amendment 015 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Updating the closing date for the following Area of Interest (AOI):

AOI #22: ReBoot 2. Updating the closing date for the following Area of Interest (AOI):

AOI #25: FASTx 3. Revising the following Area of Interest (AOI):

AOI #22: ReBoot 4. Revising the following Area of Interest (AOI):

AOI #25: FASTx

10/30/23 - Please see Amendment 016 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Pausing the following Area of Interest (AOI):

AOI #24: REPAIR

11/15/23 - Please see Amendment 017 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Reopening the following Area of Interest (AOI):

AOI #20: DRIVe Forward 2. Revising the following Area of Interest (AOI):

AOI #20: DRIVe Forward

12/13/23 - Please see Amendment 018 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Updating the closing date for the following Area of Interest (AOI):

AOI #16: Lab at Home 2. Revising the following Area of Interest (AOI):

AOI #16: Lab at Home 3. Pausing the following Area of Interest (AOI):

AOI #17: Digital MCMs 4. Updating the closing date for the following Area of Interest (AOI):

AOI #19: Healing Lungs

01/03/24 - Please see Amendment 019 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Reopening the following Area of Interest (AOI):

AOI #15: ReDIRECT 2. Revising the following Area of Interest (AOI):

AOI #15: ReDIRECT

01/10/24 - Please see Amendment 020 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Pausing the following Area of Interest (AOI):

AOI #26: Agnostic Diagnostic 2. Adding a topic to the following Area of Interest (AOI):

AOI #20: DRIVe Forward 3. Updating the closing date for the following Area of Interest (AOI):

AOI #20: DRIVe Forward

01/18/24 - Please see Amendment 021 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Adding the following Area of Interest (AOI):

AOI #27: Stopping Secondary Spread

2/5/24 - Please see Amendment 022 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Pausing the following research Area of Interest (AOI):

AOI #27: Stopping Secondary Spread 2. Revise topics for the following research Area of Interest (AOI):

AOI #20: DRIVe Forward

02/12/24 - Please see Amendment 023 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Reopening the following Area of Interest (AOI):

AOI #26: Agnostic Diagnostic

02/21/24 - Please see Amendment 024 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Updating the closing date for the following Area of Interest (AOI):

AOI #22: ReBooT 2. Updating the closing date for the following Area of Interest (AOI):

AOI #25: FASTx

03/04/24 - Please see Amendment 025 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Reopening the following Area of Interest (AOI):

AOI #24: RePAIR 2. Revising the following Area of Interest (AOI):

AOI #24: RePAIR

03/12/24 - Please see Amendment 026 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Updating the closing date for the following Area of Interest (AOI):

AOI #16: Lab at Home 2. Updating the closing date for the following Area of Interest (AOI):

AOI #19: Healing Lungs

04/22/24 - Please see Amendment 027 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Reopening the following Area of Interest (AOI):

AOI #20: DRIVe Forward 2. Removing two topic areas and adding one topic area to the following Area of Interest (AOI):

AOI #20: DRIVe Forward

05/01/24 - Please see Amendment 028 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Updating the closing date for the following Area of Interest (AOI):

AOI #15: ReDIRECT 2. Updating the closing date for the following Area of Interest (AOI):

AOI #26: Agnostic Diagnostic 3. Reopening the following Area of Interest (AOI):

AOI #17: Digital MCMs 4. Revising the following Area of Interest (AOI):

AOI #17: Digital MCMs

05/09/24 - Please see Amendment 029 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Pausing the following Area of Interest (AOI):

AOI #16: Lab at Home 2. Updating the closing date for the following Area of Interest (AOI):

AOI #19: Healing Lungs 3. Revising the following Area of Interest (AOI):

AOI #19: Healing Lungs 4. Updating the closing date for the following Area of Interest (AOI):

AOI #24: RePAIR

09/24/24 - Please see Amendment 030 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Adding the following Area of Interest (AOI):

AOI #28: Influenza Vaccine Innovation 2. Pausing the following Area of Interest (AOI):

AOI #26: Agnostic Diagnostic

09/30/24 - Please see Amendment 031 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1. Reopening the following Area of Interest (AOI):

AOI #24: RePAIR

10/10/24 - Please see Amendment 032 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

Update the closing date for the following Area of Interest (AOI):

AOI #19: Healing Lungs Pause the following Area of Interest (AOI) on 10/31/24:

AOI #17: Digital MCMs

10/31/24 - Please see Amendment 033 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

Reopen the following Area of Interest (AOI) on 11/1/24:

AOI #15: ReDIRECT 2. Remove language requiring a Rough Order of Magnitude (ROM) from the record 11/26/2024 - Please see Amendment 034 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1) Reopen the following Area of Interest (AOI):

AOI #22: ReBooT 2) Revise the following Area of Interest (AOI):

AOI #22: ReBooT 3) Pause the following Area of Interest (AOI):

AOI#24: RePAIR

1/13/2025 - Please see Amendment 035 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

1) Reopen the following Area of Interest (AOI) on 1/15/2025:

AOI #16: Lab at Home 2) Open the following Area of Interest (AOI):

AOI #29: Type to Treat

2/14/2025 - Please see Amendment 036 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this Amendment, BARDA is:

Updating the closing date for the following Area of Interest (AOI):

AOI #19: Healing Lung

4/22/2025 - Please see Amendment 037 for Easy Broad Agency Announcement (EZ-BAA) EZ-BAA-22-100-SOL-00003. Under this amendment, BARDA is revising the following Areas of Interest (AOI) to close effective immediately:

AOI #19:

Healing Lungs AOI #20:

ReBooT AOI #29: Type to Treat Additional details can be found in the corresponding Amendment 037.