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Solicitation

ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening

ARPA-H-SOL-26-165

National Institutes of Health, Advanced Research Projects Agency for Health (Arpa-H). Research and Development in Biotechnology (except Nanobiotechnology).

16 open like this View on SAM.gov Markdown

Response deadline

October 7, 2026 at 5:00 PM EDT

Closed 32 days ago. Posted October 7, 2026, first published September 16, 2026. Scheduled to archive October 22, 2026.

Get the next one like this from National Institutes of Health by email, the day it is posted.Find my opportunities

This one closed 32 days ago

16 like it are open now in research and development in biotechnology (except nanobiotechnology)

All 16 open in research and development in biotechnology (except nanobiotechnology)

Description

As published on SAM.gov.

The Advanced Research Projects Agency for Health (ARPA-H) Comprehensive Organ System Modeling in Outer Space (COSMOS) Initiative aims to definitively prove or disprove if exposure to microgravity in Low Earth Orbit (LEO) truly accelerates tissue aging across brain, cardiac, uterine, and kidney tissue types and across several adult age brackets. Provided Tissue Aging Rate in Space (TARIS) exceeds Tissue Aging Rate on Earth (TAROE) at a rate that exceeds the on Earth breakeven cost for new drug R&D, COSMOS will create a first-in-class platform for fully autonomous, high-throughput drug screening in LEO that would be more cost effective and faster than new drug R&D on Earth.

ARPA-H anticipates multiple Other Transaction awards resulting from this announcement.

Interested parties are invited to download and review the attached COSMOS Innovative Solutions Opening (ISO) ARPA-H-SOL-26-165

Amendment 01 – 17 September 2026: This amendment includes updated hyperlinks and information on the updated Solutions summary portal.

Questions and Answers – 21 September 2026: This Q&A is provided for informational purposes only and does not amend the solicitation. All other questions are due by 23 September 2026 at 5:00PM ET.

Amendment 02 – 23 September 2026: This amendment includes updates to Section 3, COSMOS Details; Section 4, Mandatory Experimental Design; as well as Correction to Figure 2.

Questions and Answers – 25 September 2026: This Q&A is provided for informational purposes only and does not amend the solicitation.

Amendment 03 – 07 October 2026: This amendment extends the submission time, now due 07 October 2026, 5:00pm ET.

Attachments

Files listed on SAM.gov. The ones we hold a copy of download from here; the rest open SAM's download, which needs no account.

Publications

Every notice SAM.gov issued under this solicitation number, oldest first. Each is a separate record on SAM.

  1. September 16, 2026

    Solicitation

    Due October 7, 2026 at 2:00 PM EDT. SAM.gov, notice f7ed4368bf8c48e39ca45d3204830c25

    1 revisions on SAM
    • September 16, 2026: publish, solicitation

  2. September 17, 2026

    Solicitation

    Due October 7, 2026 at 2:00 PM EDT. SAM.gov, notice a0daed815bbc41289b0477bf9520ab1b

    2 revisions on SAM
    • September 17, 2026: publish, solicitation
    • September 16, 2026: publish, solicitation

  3. September 21, 2026

    Solicitation

    Due October 7, 2026 at 2:00 PM EDT. SAM.gov, notice 7fb62afa210e4e209bb0110a6ea477eb

    3 revisions on SAM
    • September 21, 2026: publish, solicitation
    • September 17, 2026: publish, solicitation
    • September 16, 2026: publish, solicitation

  4. September 23, 2026

    Solicitation

    Due October 7, 2026 at 2:00 PM EDT. SAM.gov, notice b92d3dc2c5c14c3aac3531c48ad79978

    4 revisions on SAM
    • September 23, 2026: publish, solicitation
    • September 21, 2026: publish, solicitation
    • September 17, 2026: publish, solicitation
    • September 16, 2026: publish, solicitation

  5. September 25, 2026

    Solicitation

    Due October 7, 2026 at 2:00 PM EDT. SAM.gov, notice 8fad2e0c9f0b4559b939760a3f82ebbb

    5 revisions on SAM
    • September 25, 2026: publish, solicitation
    • September 23, 2026: publish, solicitation
    • September 21, 2026: publish, solicitation
    • September 17, 2026: publish, solicitation
    • September 16, 2026: publish, solicitation

  6. October 7, 2026

    Solicitation

    Due October 7, 2026 at 5:00 PM EDT. SAM.gov, notice d38a0249fdb64fbabceb7eef112d6f07

    6 revisions on SAM
    • October 7, 2026: publish, solicitation
    • September 25, 2026: publish, solicitation
    • September 23, 2026: publish, solicitation
    • September 21, 2026: publish, solicitation
    • September 17, 2026: publish, solicitation
    • September 16, 2026: publish, solicitation

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