# ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening

Canonical: https://abierto.us/opportunities/arpahsol26165

- Solicitation number: ARPA-H-SOL-26-165
- Notice type: Solicitation
- Status: Open. Offers due October 7, 2026 at 2:00 PM EDT
- Department: Department of Health and Human Services
- Agency: National Institutes of Health
- Contracting office: Advanced Research Projects Agency for Health (Arpa-H) (75N992)
- NAICS: 541714 Research and Development in Biotechnology (except Nanobiotechnology)
- Product or service code: AN13 Health R&D Services; Health Care Services; Experimental Development
- First posted: September 16, 2026
- Last posted: September 16, 2026
- SAM.gov: https://sam.gov/workspace/contract/opp/f7ed4368bf8c48e39ca45d3204830c25/view

## Description

The Advanced Research Projects Agency for Health (ARPA-H) Comprehensive Organ System Modeling in Outer Space (COSMOS) Initiative aims to definitively prove or disprove if exposure to microgravity in Low Earth Orbit (LEO) truly accelerates tissue aging across brain, cardiac, uterine, and kidney tissue types and across several adult age brackets. Provided Tissue Aging Rate in Space (TARIS) exceeds Tissue Aging Rate on Earth (TAROE) at a rate that exceeds the on Earth breakeven cost for new drug R&D, COSMOS will create a first-in-class platform for fully autonomous, high-throughput drug screening in LEO that would be more cost effective and faster than new drug R&D on Earth.

ARPA-H anticipates multiple Other Transaction awards resulting from this announcement.

Interested parties are invited to download and review the attached COSMOS Innovative Solutions Opening (ISO) ARPA-H-SOL-26-165

## Attachments

- [ARPA-H-SOL-26-165_COSMOS_ISO.docx](https://sam.gov/api/prod/opps/v3/opportunities/resources/files/08aa48d885fc42bf86957b0a03e8c61c/download)

## Publications

- September 16, 2026: Solicitation, due October 7, 2026 at 2:00 PM EDT. Notice f7ed4368bf8c48e39ca45d3204830c25. https://sam.gov/workspace/contract/opp/f7ed4368bf8c48e39ca45d3204830c25/view

## Points of contact

- COSMOS Team, COSMOS@ARPA-H.GOV

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/arpahsol26165.