Solicitation
Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO)
ARPA-H-SOL-26-139
National Institutes of Health, Advanced Research Projects Agency for Health (Arpa-H). Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology).
Response deadline
May 28, 2026 at 1:00 PM EDT
Closed 157 days ago. Posted May 26, 2026, first published February 17, 2026. Scheduled to archive June 12, 2026.
Get the next one like this from National Institutes of Health by email, the day it is posted.Find my opportunities
This one closed in 2026
127 like it are open now in research and development in the physical, engineering, and life sciences (except nanotechnology and biotechnology)
- SBIR FY26 Phase I Broad Agency Announcement
Environmental Protection Agency, Water, Tribal & Science Division
SolicitationSmall businessNAICS 541715Anywhere in the US68HERW26R0102Closes in 8 daysNov 9 - System of systems Technology Integration Tool Chain for Heterogeneous Electronic Systems (STITCHES) Sources Sought
Department of the Air Force, FA2057 AFLCMC HNJK
Sources soughtNAICS 541715Location not publishedSTITCHES_001Closes in 13 daysNov 14 - Synthesis and Distribution of Drugs of Abuse and Related Compounds
National Institutes of Health, National Institutes of Health Nida
Sources soughtNAICS 541715Anywhere in the US75N98027R00006OTCloses in 19 daysNov 20
Description
As published on SAM.gov.
Responses to all questions received have been posted on the CIRCLE program page. At this time, additional questions will not receive responses.
The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) solicitation in support of the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from this announcement.
CIRCLE seeks to create a critical illness Control Point Validation Engine that leads to improvements in intensive care unit (ICU) health outcomes, coupled to reduced stay time and associated costs, by assessing, predicting, and treating immuno-inflammatory dysregulation before it causes organ failure.
Interested parties are invited to review the attached CIRCLE ISO ARPA-H-SOL-26-139 and its Attachments A – F.
Proposer's Day: Wednesday, March 11, 2026 (ARPA-H-SN-26-149)
Solution Summaries Due: Monday, March 30, 2026, 1 PM ET (to https://solutions.arpa-h.gov)
Questions Due: Friday, May 22, 2026, 1 PM ET (to https://solutions.arpa-h.gov/Ask-A-Question/)
Full Proposals Due: Thursday, May 28, 2026, 1 PM ET (to https://solutions.arpa-h.gov)
ARPA-H will not reimburse potential proposers for time and effort related to submission of solution summaries or proposals. When planning a response to this notice, proposers should consider that some parts of the submission process may take from one business day to one month to complete.
-------------------------- Amendment 1 --------------------------
The purpose of this amendment is to: change the proposal submission date to Thursday, May 28, 2026 and replace Office of Commercialization (OC) with ARPA-H.
-------------------------- Amendment 2 --------------------------
The purpose of this amendment is to provide revisions as highlighted in yellow in the attached documents.
-------------------------- Amendment 3 --------------------------
The purpose of this amendment is to provide revisions as highlighted in yellow in the attached documents.
-------------------------- Amendment 4 --------------------------
The purpose of this amendment is to provide revisions as highlighed in yellow in the attached documents.
Attachments
Files listed on SAM.gov. The ones we hold a copy of download from here; the rest open SAM's download, which needs no account.
- Att F - VOLUME 3_Administrative and National Policy - CIRCLE.docx69 KB, February 17, 2026
Publications
Every notice SAM.gov issued under this solicitation number, oldest first. Each is a separate record on SAM.
February 17, 2026
Solicitation
Due May 29, 2026 at 1:00 PM EDT. SAM.gov, notice a890cc996d3946678fdf92306c58f328
7 revisions on SAM
- May 26, 2026: publish, solicitation
- May 21, 2026: publish, solicitation
- April 28, 2026: publish, solicitation
- March 23, 2026: publish, solicitation
- February 20, 2026: publish, solicitation
- February 17, 2026: publish, special notice
- February 17, 2026: publish, solicitation
February 20, 2026
Solicitation
Due May 28, 2026 at 1:00 PM EDT. SAM.gov, notice 772dd7a260404a0ab3c62a06c03e1e0b
6 revisions on SAM
- May 26, 2026: publish, solicitation
- May 21, 2026: publish, solicitation
- April 28, 2026: publish, solicitation
- March 23, 2026: publish, solicitation
- February 20, 2026: publish, solicitation
- February 17, 2026: publish, solicitation
March 23, 2026
Solicitation
Due May 28, 2026 at 1:00 PM EDT. SAM.gov, notice 0993e235f83347b386772f7008e38043
6 revisions on SAM
- May 26, 2026: publish, solicitation
- May 21, 2026: publish, solicitation
- April 28, 2026: publish, solicitation
- March 23, 2026: publish, solicitation
- February 20, 2026: publish, solicitation
- February 17, 2026: publish, solicitation
April 28, 2026
Solicitation
Due May 28, 2026 at 1:00 PM EDT. SAM.gov, notice 676f389d5af74d138c1e3b9e49b9b6a2
6 revisions on SAM
- May 26, 2026: publish, solicitation
- May 21, 2026: publish, solicitation
- April 28, 2026: publish, solicitation
- March 23, 2026: publish, solicitation
- February 20, 2026: publish, solicitation
- February 17, 2026: publish, solicitation
May 21, 2026
Solicitation
Due May 28, 2026 at 1:00 PM EDT. SAM.gov, notice 2509b69212a149c7af8c8fc7695090de
6 revisions on SAM
- May 26, 2026: publish, solicitation
- May 21, 2026: publish, solicitation
- April 28, 2026: publish, solicitation
- March 23, 2026: publish, solicitation
- February 20, 2026: publish, solicitation
- February 17, 2026: publish, solicitation
May 26, 2026
Solicitation
Due May 28, 2026 at 1:00 PM EDT. SAM.gov, notice f4721e35ef2b47149be60e6c611561f4
6 revisions on SAM
- May 26, 2026: publish, solicitation
- May 21, 2026: publish, solicitation
- April 28, 2026: publish, solicitation
- March 23, 2026: publish, solicitation
- February 20, 2026: publish, solicitation
- February 17, 2026: publish, solicitation
Points of contact
- ARPA-H RSO CIRCLE ISO CoordinatorCIRCLE@ARPA-H.gov