# Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO)

Canonical: https://abierto.us/opportunities/arpahsol26139

- Solicitation number: ARPA-H-SOL-26-139
- Notice type: Solicitation
- Status: Closed. Deadline was May 28, 2026 at 1:00 PM EDT
- Department: Department of Health and Human Services
- Agency: National Institutes of Health
- Contracting office: Advanced Research Projects Agency for Health (Arpa-H) (75N992)
- NAICS: 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Product or service code: AN13 Health R&D Services; Health Care Services; Experimental Development
- First posted: February 17, 2026
- Last posted: May 26, 2026
- SAM.gov: https://sam.gov/workspace/contract/opp/f4721e35ef2b47149be60e6c611561f4/view

## Description

Responses to all questions received have been posted on the CIRCLE program page. At this time, additional questions will not receive responses. The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) solicitation in support of the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from this announcement.

CIRCLE seeks to create a critical illness Control Point Validation Engine that leads to improvements in intensive care unit (ICU) health outcomes, coupled to reduced stay time and associated costs, by assessing, predicting, and treating immuno-inflammatory dysregulation before it causes organ failure. Interested parties are invited to review the attached CIRCLE ISO ARPA-H-SOL-26-139 and its Attachments A – F. Proposer's Day: Wednesday, March 11, 2026 (ARPA-H-SN-26-149)

**Solution Summaries Due:** Monday, March 30, 2026, 1 PM ET (to https://solutions.arpa-h.gov)

**Questions Due:** Friday, May 22, 2026, 1 PM ET (to https://solutions.arpa-h.gov/Ask-A-Question/)

**Full Proposals Due:** Thursday, May 28, 2026, 1 PM ET (to https://solutions.arpa-h.gov) ARPA-H will not reimburse potential proposers for time and effort related to submission of solution summaries or proposals. When planning a response to this notice, proposers should consider that some parts of the submission process may take from one business day to one month to complete.

Amendment 1

The purpose of this amendment is to:

change the proposal submission date to Thursday, May 28, 2026 and replace Office of Commercialization (OC) with ARPA-H.

Amendment 2

The purpose of this amendment is to provide revisions as highlighted in yellow in the attached documents.

Amendment 3

The purpose of this amendment is to provide revisions as highlighted in yellow in the attached documents.

Amendment 4

The purpose of this amendment is to provide revisions as highlighed in yellow in the attached documents.

## Publications

- February 17, 2026: Solicitation, due May 29, 2026 at 1:00 PM EDT. Notice a890cc996d3946678fdf92306c58f328. https://sam.gov/workspace/contract/opp/a890cc996d3946678fdf92306c58f328/view
- February 20, 2026: Solicitation, due May 28, 2026 at 1:00 PM EDT. Notice 772dd7a260404a0ab3c62a06c03e1e0b. https://sam.gov/workspace/contract/opp/772dd7a260404a0ab3c62a06c03e1e0b/view
- March 23, 2026: Solicitation, due May 28, 2026 at 1:00 PM EDT. Notice 0993e235f83347b386772f7008e38043. https://sam.gov/workspace/contract/opp/0993e235f83347b386772f7008e38043/view
- April 28, 2026: Solicitation, due May 28, 2026 at 1:00 PM EDT. Notice 676f389d5af74d138c1e3b9e49b9b6a2. https://sam.gov/workspace/contract/opp/676f389d5af74d138c1e3b9e49b9b6a2/view
- May 21, 2026: Solicitation, due May 28, 2026 at 1:00 PM EDT. Notice 2509b69212a149c7af8c8fc7695090de. https://sam.gov/workspace/contract/opp/2509b69212a149c7af8c8fc7695090de/view
- May 26, 2026: Solicitation, due May 28, 2026 at 1:00 PM EDT. Notice f4721e35ef2b47149be60e6c611561f4. https://sam.gov/workspace/contract/opp/f4721e35ef2b47149be60e6c611561f4/view

## Points of contact

- ARPA-H RSO CIRCLE ISO Coordinator, CIRCLE@ARPA-H.gov

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/arpahsol26139.