Air-liquid interface (ALI) exposure system with installation and training post award and one year of warranty.

USAMRICD requires the acquisition of an air-liquid interface (ALI) exposure system with installation and training post award and one year of warranty. Acquisition of a high-performance ALI exposure system is needed to provide controlled environmental chamber with aerosol exposure capabilities, including gas, vapor, particulate, and mixed aerosols, to human ALI models (ciliated airway, alveolar/endothelial deep lung, commercial pulmonary tissue, precision cut lung slices) of the human respiratory tract.

The ALI exposure system required will need temperature and humidity control and real-time monitoring, modular, versatile, and flexible design to adapt system to match test article exposure characteristics, ability to hold different ALI insert and tissue types, use electrostatic deposition to maximize particle deposition on tissue models, expose between 6 – 24 samples at one time to one or multiple doses, provide high quality and repeatable data comparable to published scientific literature, compatibility to interface with different atmosphere generation systems, provide real-time deposited mass dose data to ALI models, and provide easy maintenance, cleaning, and turnaround times for next experiment.

The requirement will also need any associated sample holders and real-time monitoring software supporting the specialized software and equipment. The CelTox Sampler system from MEDTEC BIOLAB, INC. is the only identified ALI exposure system capable of meeting the minimal essential characteristics (MEC).