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Solicitation

Smart Red Blood Cells (Smart-RBC)

DARPA-PS-26-02

Defense Advanced Research Projects Agency, Def Advanced Research Projects Agcy. Research and Development in Biotechnology (except Nanobiotechnology).

18 open like this View on SAM.gov Markdown

Response deadline

January 14, 2026

Closed 291 days ago. Posted October 17, 2025. Scheduled to archive February 13, 2026.

Get the next one like this from Defense Advanced Research Projects Agency by email, the day it is posted.Find my opportunities

This one closed in 2026

18 like it are open now in research and development in biotechnology (except nanobiotechnology)

All 18 open in research and development in biotechnology (except nanobiotechnology)

Description

As published on SAM.gov.

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals in support of the Smart Red Blood Cells program (Smart-RBC). The DARPA Smart-RBC program aims to engineer red blood cells to contain novel biological features that can safely, temporarily, and reliably alter human physiology. Specifically, the Smart-RBC program will revolutionize blood products by creating “smart red blood cells” (SRBCs). SRBCs will be engineered to contain additional biological circuits consisting of three layers: Sense extracellular biomarkers; Decide next steps; Act by creating effector molecules that can alter metabolism or physiology. The program will identify the art-of-the-possible to create SRBCs to enhance human performance and maximize survival via hemostasis products. This program does not include clinical trials or direct human testing.

Attachments

Files listed on SAM.gov. The ones we hold a copy of download from here; the rest open SAM's download, which needs no account.

Publications

Every notice SAM.gov issued under this solicitation number, oldest first. Each is a separate record on SAM.

  1. October 17, 2025

    Solicitation

    Due January 14, 2026. SAM.gov, notice a0160217c997497c897c3320db9dcb7f

    1 revisions on SAM
    • October 17, 2025: publish, solicitation

Points of contact