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Solicitation

BioStabilization Systems (BoSS)

ARPA-H-SOL-26-136

National Institutes of Health, Advanced Research Projects Agency for Health (Arpa-H). Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology).

127 open like this View on SAM.gov Markdown

Response deadline

May 21, 2026 at 5:00 PM EDT

Closed 164 days ago. Posted May 14, 2026, first published December 2, 2025. Scheduled to archive June 5, 2026.

Get the next one like this from National Institutes of Health by email, the day it is posted.Find my opportunities

This one closed in 2026

127 like it are open now in research and development in the physical, engineering, and life sciences (except nanotechnology and biotechnology)

All 127 open in research and development in the physical, engineering, and life sciences (except nanotechnology and biotechnology)

Description

As published on SAM.gov.

Amendment 3:

The purpose of this amendment is to amend the Attachments. Changes to the attachments are listed below:

  • Attachment 3 Cost Proposal Narrative: references to "lead organization" were changes to "lead member." See red text on the cover page.
  • Attachment 4 Cost Proposal Spreadsheet: On the General tab in the yellow box, under the "Instructions for using this template." See red text on the General tab.

Please carefully review the amended ISO for all changes. 

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Amendment 2:

The purpose of this amendment is to amend the BoSS ISO. An updated version of the ISO, with changes in red font, is included as an attachment to this amendment. 

Changes to the ISO include (but are not limited to):

  • clarification of examples of out-of-scope approaches (Table 1)
  • update to capability requirements (Section 1.3 Program Overview)
  • update to allowable IV&V partner entity types (Section 2)
  • update to reporting requirements (Section 3.4 Programmatic Deliverables)

Please carefully review the amended ISO for all changes. 

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Amendment 1 corrects a formatting error on references to Table 2.

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Program Description:

The BioStabilization Systems (BoSS) program aims to transform how live cell-based therapies are stabilized, manufactured, and distributed. At its core, BoSS addresses a foundational bottleneck in the delivery of advanced cell and gene therapies (CGTs): the critical dependence on ultra-cold conditions (-80 to -196˚C) for storage and transport. BoSS will yield a bioprocessing system that enables scalable production of thermally stable cells, paving the way for a new era of efficient and resilient manufacturing and distribution of biologics without any need for cold storage. BoSS-developed technologies will also accelerate many other avenues in biotechnology that directly impact healthcare, including bio-surveillance, regenerative medicine, large-scale genetic testing, blood product supply, and wound repair, in addition to improving access to a wide range of existing biotherapeutics. 

Solution Summaries are required: 

For consideration as a Performer: 

  • Solution Summary due date: February 19th, 2026 5:00 PM ET 

For consideration as an IV&V partner:  

  • Solution Summary due date: April 17th, 2026 5:00 PM ET 

Interested parties are invited to review the attached BoSS Innovative Solutions Opening (ISO) ARPA-H -SOL-26-136. 

Submissions must be made to:

  • Solution Summary Submission Site: https://solutions.arpa-h.gov/Submit-Solution/

Please ensure to follow this opportunity for any updates.

For more information on the BoSS program visit: https://arpa-h.gov/explore-funding/programs/boss.

For information on Proposer's Day details and registration information, please see Special Notice ARPA-H-SN-26-137.

Attachments

Files listed on SAM.gov. The ones we hold a copy of download from here; the rest open SAM's download, which needs no account.

Publications

Every notice SAM.gov issued under this solicitation number, oldest first. Each is a separate record on SAM.

  1. December 2, 2025

    Solicitation

    Due March 26, 2026 at 5:00 PM EDT. SAM.gov, notice 372c6d71933a4d76a899cff981a9df84

    7 revisions on SAM
    • May 14, 2026: publish, solicitation
    • May 14, 2026: publish, solicitation
    • February 6, 2026: publish, solicitation
    • January 26, 2026: publish, solicitation
    • December 24, 2025: publish, solicitation
    • December 2, 2025: publish, solicitation
    • December 2, 2025: publish, solicitation

  2. December 2, 2025

    Solicitation

    Due March 26, 2026 at 5:00 PM EDT. SAM.gov, notice aadd5b36db484e0a8f4e29d77af9f081

    8 revisions on SAM
    • May 14, 2026: publish, solicitation
    • May 14, 2026: publish, solicitation
    • February 6, 2026: publish, solicitation
    • January 26, 2026: publish, solicitation
    • December 2, 2025: publish, special notice
    • December 24, 2025: publish, solicitation
    • December 2, 2025: publish, solicitation
    • December 2, 2025: publish, solicitation

  3. December 24, 2025

    Solicitation

    Due March 26, 2026 at 5:00 PM EDT. SAM.gov, notice 47aa2e23723f48889849775703378361

    7 revisions on SAM
    • May 14, 2026: publish, solicitation
    • May 14, 2026: publish, solicitation
    • February 6, 2026: publish, solicitation
    • January 26, 2026: publish, solicitation
    • December 24, 2025: publish, solicitation
    • December 2, 2025: publish, solicitation
    • December 2, 2025: publish, solicitation

  4. January 26, 2026

    Solicitation

    Due March 26, 2026 at 5:00 PM EDT. SAM.gov, notice 7b372e473c844a74a0e236e981e972db

    7 revisions on SAM
    • May 14, 2026: publish, solicitation
    • May 14, 2026: publish, solicitation
    • February 6, 2026: publish, solicitation
    • January 26, 2026: publish, solicitation
    • December 24, 2025: publish, solicitation
    • December 2, 2025: publish, solicitation
    • December 2, 2025: publish, solicitation

  5. February 6, 2026

    Solicitation

    Due March 26, 2026 at 5:00 PM EDT. SAM.gov, notice e87bcb56f94a4e1b98761057b5b0d75d

    7 revisions on SAM
    • May 14, 2026: publish, solicitation
    • May 14, 2026: publish, solicitation
    • February 6, 2026: publish, solicitation
    • January 26, 2026: publish, solicitation
    • December 24, 2025: publish, solicitation
    • December 2, 2025: publish, solicitation
    • December 2, 2025: publish, solicitation

  6. May 14, 2026

    Solicitation

    Due May 21, 2026 at 5:00 PM EDT. SAM.gov, notice 386dd9dd3af249ee802bdba70106d610

    7 revisions on SAM
    • May 14, 2026: publish, solicitation
    • May 14, 2026: publish, solicitation
    • February 6, 2026: publish, solicitation
    • January 26, 2026: publish, solicitation
    • December 24, 2025: publish, solicitation
    • December 2, 2025: publish, solicitation
    • December 2, 2025: publish, solicitation

  7. May 14, 2026

    Solicitation

    Due May 21, 2026 at 5:00 PM EDT. SAM.gov, notice 8bcb9b5f40e54ffb93c36cda21444ab5

    7 revisions on SAM
    • May 14, 2026: publish, solicitation
    • May 14, 2026: publish, solicitation
    • February 6, 2026: publish, solicitation
    • January 26, 2026: publish, solicitation
    • December 24, 2025: publish, solicitation
    • December 2, 2025: publish, solicitation
    • December 2, 2025: publish, solicitation

Points of contact