Medicinal Chemistry Support for Therapeutic Development: Synthesis of HERV-K Protease Inhibitors

COMBINED SYNOPSIS / SOLICITATION Title:

Medicinal Chemistry Support for Therapeutic Development: Synthesis of HERV-K Protease Inhibitors This is a combined synopsis/solicitation for commercial items prepared in accordance with FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested, and a separate written solicitation will not be issued. The solicitation number is 75N98026Q00906.

This solicitation is issued as a competitive combined synopsis/solicitation for commercial products or commercial services. The Government intends to award a contract or purchase order resulting from this solicitation using full and open competition. This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold of $350,000.00.

The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, seeks to award a Firm-Fixed-Price to the responsible offeror whose proposal represents the best value to the Government. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2026-01 March 13, 2026. The associated NAICS code is 541380, and the small business size standard is N/A. This requirement is NOT A SET-ASIDE for small businesses.

Description of Requirement: Medicinal Chemistry The provision at FAR 52.212-1, Instructions to Offerors—Commercial Items, applies to this acquisition. Add any agency-specific instructions as required. The provision at FAR 52.212-2, Evaluation—Commercial Items, applies to this acquisition. The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation represents the best value to the Government, price and other factors considered.

Evaluation Factors: Technical capability Price Past performance Delivery schedule A written notice of award or acceptance of an offer, issued within the time specified in the offer, shall result in a binding contract without further action by either party. The Government reserves the right to accept any offer before the expiration date. Offerors shall include a completed copy of FAR 52.212-3, Offeror Representations and Certifications—Commercial Items, with their offer.

FAR 52.212-4, Contract Terms and Conditions—Commercial Items, applies to this acquisition. FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders—Commercial Items, applies to this acquisition.

Submission Requirements: Responses must include sufficient information to demonstrate the offeror’s capability to provide the required product or service.

Quotes shall include, at a minimum: Unit and total price Shipping and handling costs Delivery timeframe after award Delivery terms F.O.B. point (destination) Product or catalog numbers (if applicable) Product/service description Additional evaluation considerations may include past performance, warranty, lifecycle cost, maintenance availability, and environmental or energy efficiency. Responses must include the Unique Entity Identifier (UEI), Taxpayer Identification Number (TIN), and business size certification.

All offerors must be actively registered in the System for Award Management (SAM) at www.sam.gov. All responses must be received by August 10, 2026 at 9:00 AM and must reference solicitation number 75N98026Q00906. Responses may be submitted electronically to James.Law@nih.gov.

Point of Contact: James Law James.law@nih.gov