Research and development (R&D) that will contribute toward Advanced Research Projects Agency for Health (ARPA-H) mission needs and Small Business Innovation Research (SBIR) program objectives.

Amendment 5 is hereby issued to provide Answers to solicitation questions received by the due date and time for receipt of questions. All Amendments are provided in the Attachments section of this solicitation.

Amendment 4 is hereby issued to provide Answers to solicitation questions received by the due date and time for receipt of questions. In addition, due to a small typographical error identified in Objectives section of the Appendix A Phase I Technical Proposal, this attachment has been updated, and the corrected file attachment has been added to replace to original. See Q&A for Amendment 4 for further information. All Amendments are provided in the Attachments section of this solicitation. One more Amendment will be issued over the next few days to provide answers to all remaining questions.

Amendment 3 is hereby provided to extend the Due Date for the submission of proposals to February 29, 2024, 5:00PM ET. All amendments are attached to this posting. Please scroll down to the bottom of the page to see the attachments of all amendments as well as all the original solicitation documents. The Government is working to compile and finalize the answers to all questions received prior to the due date and time for solicitation questions, and another Amendment is forthcoming to provide answers to all the remainder of the questions.

Amendments 1 and 2 were posted under a separate posting in SAM.gov. However, due to the difficulty of interested vendors in locating these amendments postings in SAM.gov, the Amendments have been attached here as well.

SOLICITATION The Advanced Research Projects Agency for Health (ARPA-H) invites small business concerns (SBCs) to submit research proposals under this Small Business Innovation Research (SBIR) Contract Solicitation. Firms with the capability to conduct research and development (R&D) and to commercialize the results of that R&D, are encouraged to participate.

This solicitation invites proposals in the following areas: ARPA-H 01 - Inexpensive plant-based manufacturing of viral vectors for gene therapies ARPA-H 02 - LymphoLab ProDiscover Kit ARPA-H 03 - Continuous Monitoring of Vascular health using Smart Biomimetic Implantables ARPA-H 04 - Personalized medicine platform for predicting response to immunotherapy ARPA-H 05 - Saving Baby Hearts: Fully Autonomous Neonatal Echocardiography for the Diagnosis of Critical Congenital Heart Disease ARPA-H 06 - Improving Identity and Access Management with Clinical Context Deadline for Questions: Solicitation questions must be received by February 15, 2024, 5:00 PM EDT. Please send questions to the ARPA-H SBIR/STTR Program mailbox (sbir@arpa-h.gov).