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Special notice

Soleimanpour/Kauffman Univ of Pittsburgh mTDNA Research

36C25024Q0347

Department of Veterans Affairs, 250-Network Contract Office 10. Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology).

127 open like this View on SAM.gov Markdown

Response deadline

February 29, 2024 at 4:00 PM EST

Closed 976 days ago. Posted February 21, 2024. Scheduled to archive March 30, 2024.

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This one closed in 2024

127 like it are open now in research and development in the physical, engineering, and life sciences (except nanotechnology and biotechnology)

All 127 open in research and development in the physical, engineering, and life sciences (except nanotechnology and biotechnology)

Description

As published on SAM.gov.

The Department of Veterans Affairs, VA Ann Arbor Medical Center VISN 10,2215 Fuller Road, Ann Arbor MI 48105, in accordance with FAR 13.106-1(b), intends to award a contract request on a sole source basis with the University of Pittsburgh for the provision of expertise is the involvement of mitochondrial dysfunction in disease and how aberrant mitochondrial DNA (mtDNA) metabolism contributes to disease progression. NAICS 541715 and PSC code AB13 apply.

Dr. Kaufman is an Associate Professor in the Department of Medicine at the University of Pittsburgh. Dr. Kaufman s expertise is in the involvement of mitochondrial dysfunction in disease and how aberrant mitochondrial DNA (mtDNA) metabolism contributes to disease progression.

Dr. Kaufman s long expertise in the study of mtDNA copy number control, mtDNA replication, and mtRNA transcription, specifically involving Tfam, serves a critical member of the research team to execute studies related to defective mitochondrial biogenesis in beta cells. Detection of mtDNA deletions will be performed in the Kaufman Lab.

Further, we will survey changes in mitochondrial antioxidant defense pathway by measuring expression of key antioxidant genes, including Prdx3, Txn2, Txnrd2, Ucp2, and Sod2, by qRT-PCR. As Director of the Mitochondrial Genetics Core for the Center for Metabolism and Mitochondrial Medicine, Dr. Kaufman also will be able to provide fee-for-service technical support for these assays on an as needed basis. Period of performance is estimated as follows:

Base: March, 1st 2024 through February, 28th 2025 This notice of intent is not a request for competitive proposals. It is not a solicitation or request for offers. No solicitation package is available. A determination not to compete is solely within the discretion of the Government. Any response to this notice must show clear and convincing evidence that competition would be advantageous to the Government. Responses must be received no later than 4:00 pm EST on February 29th, 2024. No telephone inquiries will be accepted. All responses must be sent by email to kevin.adkins@va.gov

Publications

Every notice SAM.gov issued under this solicitation number, oldest first. Each is a separate record on SAM.

  1. February 21, 2024

    Special notice

    Due February 29, 2024 at 4:00 PM EST. SAM.gov, notice 5acb6067baad447c975fef5fc732825f

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