Computational ADME Tox AnaLYsis for Safer Therapeutics (CATALYST) Innovative Solutions Opening

The purpose of the amendment is to extend the due date for proposals to February 14, 2025 at 5PM ET. In addition, the amendment clarifies a discrepancy between the Cost Proposal Narrative and Cost Proposal Spreadsheet bundle attachments. Specifically, the amendment clarifies that any material and equipment item exceeding $5,000 requires back-up documentation (e.g., copy of catalog price lists, past purchase order or invoice, or vendor quotes prior to purchase).

The purpose of the amendment is provide the website address for the program FAQ. Please see below:

https://arpa-h.gov/research-and-funding/programs/catalyst/faqs Please visit the FAQ for updates as Questions & Answers may be added prior to the closing date for receipt of proposals.

The purpose of the amendment is provide a correction to the Bundle of Attachments.

Specifically:

1. ARPA-H ADMIN & NATIONAL POLICY (Other Transaction) is updated to add paragraph 11. Synthetic Nucleic Acids Or Benchtop Nucleic Acid Synthesis Equipment.

2. ARPA-H TECH & MANAGEMENT is updated to correct the page limit to thirty-five (35) pages. In addition, the language regarding team members, subawardees, subcontractors, vendors, etc. has been updated to better reflect the program structure. No changes were made to the other Bundle of Attachment documents.

The purpose of the amendment is provide the proposal Bundle of Attachments.

The purpose of the amendment is provide an FAQ for the program. Please see the below attachment.

The Advanced Research Projects Agency for Health (ARPA-H) posts this Innovative Solutions Opening (ISO) in support of its Computational ADME Tox AnaLYsis for Safer Therapeutics (CATALYST) Program. ARPA-H anticipates multiple other transaction awards. Interested parties are invited to review the attached CATALYST ISO. Solution summaries are due November 25, 2024, 5:00 PM ET. A solution summary must be submitted to submit a proposal. Submissions must be made to:

Solution Summary Submission Site: https://solutions.arpa-h.gov/Submit-Solution/ Proposal Submission Site: https://solutions.arpa-h.gov/Submit-Proposal/ Proposal Submission Questions: https://solutions.arpa-h.gov/Ask-A-Question/ Please ensure to follow this opportunity for any updates. For more information about CATALYST, please visit this website: https://arpa-h.gov/research-and-funding/programs/catalyst