# Computational ADME Tox AnaLYsis for Safer Therapeutics (CATALYST) Innovative Solutions Opening

Canonical: https://abierto.us/opportunities/arpahsol24114

- Solicitation number: ARPA-H-SOL-24-114
- Notice type: Solicitation (first published as presolicitation)
- Status: Closed. Deadline was February 14, 2025 at 5:00 PM EST
- Department: Department of Health and Human Services
- Agency: National Institutes of Health
- Contracting office: Advanced Research Projects Agency for Health (Arpa-H) (75N992)
- NAICS: 541714 Research and Development in Biotechnology (except Nanobiotechnology)
- Product or service code: AN13 Health R&D Services; Health Care Services; Experimental Development
- Place of performance: Washington, District of Columbia
- County: District of Columbia (FIPS 11001). https://abierto.us/counties/district-of-columbia-dc-11001
- City: Washington. https://abierto.us/cities/washington-dc-1150000
- First posted: October 16, 2024
- Last posted: January 16, 2025
- SAM.gov: https://sam.gov/workspace/contract/opp/f0b8597cceb4499a976874963338fd1d/view

## Description

The purpose of the amendment is to extend the due date for proposals to February 14, 2025 at 5PM ET. In addition, the amendment clarifies a discrepancy between the Cost Proposal Narrative and Cost Proposal Spreadsheet bundle attachments. Specifically, the amendment clarifies that any material and equipment item exceeding $5,000 requires back-up documentation (e.g., copy of catalog price lists, past purchase order or invoice, or vendor quotes prior to purchase).

The purpose of the amendment is provide the website address for the program FAQ. Please see below:

https://arpa-h.gov/research-and-funding/programs/catalyst/faqs Please visit the FAQ for updates as Questions & Answers may be added prior to the closing date for receipt of proposals.

The purpose of the amendment is provide a correction to the Bundle of Attachments.

**Specifically:**

1. ARPA-H ADMIN & NATIONAL POLICY (Other Transaction) is updated to add paragraph 11. Synthetic Nucleic Acids Or Benchtop Nucleic Acid Synthesis Equipment.

2. ARPA-H TECH & MANAGEMENT is updated to correct the page limit to thirty-five (35) pages. In addition, the language regarding team members, subawardees, subcontractors, vendors, etc. has been updated to better reflect the program structure. No changes were made to the other Bundle of Attachment documents.

The purpose of the amendment is provide the proposal Bundle of Attachments.

The purpose of the amendment is provide an FAQ for the program. Please see the below attachment.

The Advanced Research Projects Agency for Health (ARPA-H) posts this Innovative Solutions Opening (ISO) in support of its Computational ADME Tox AnaLYsis for Safer Therapeutics (CATALYST) Program. ARPA-H anticipates multiple other transaction awards. Interested parties are invited to review the attached CATALYST ISO. Solution summaries are due November 25, 2024, 5:00 PM ET. A solution summary must be submitted to submit a proposal. Submissions must be made to:

**Solution Summary Submission Site:** https://solutions.arpa-h.gov/Submit-Solution/ Proposal Submission Site: https://solutions.arpa-h.gov/Submit-Proposal/ Proposal Submission Questions: https://solutions.arpa-h.gov/Ask-A-Question/ Please ensure to follow this opportunity for any updates. For more information about CATALYST, please visit this website: https://arpa-h.gov/research-and-funding/programs/catalyst

## Publications

- October 16, 2024: Presolicitation, due November 25, 2024 at 5:00 PM EST. Notice a70f8aea3b854b8c8bd7bd0c1fca22a7. https://sam.gov/workspace/contract/opp/a70f8aea3b854b8c8bd7bd0c1fca22a7/view
- November 1, 2024: Solicitation, due November 25, 2024 at 5:00 PM EST. Notice 325e7a5a97124b6b9b4916818e88cb91. https://sam.gov/workspace/contract/opp/325e7a5a97124b6b9b4916818e88cb91/view
- November 1, 2024: Presolicitation, due November 25, 2024 at 5:00 PM EST. Notice ea1e0e7aec1c4286bba7734ccddbba4d. https://sam.gov/workspace/contract/opp/ea1e0e7aec1c4286bba7734ccddbba4d/view
- November 14, 2024: Solicitation, due November 25, 2024 at 5:00 PM EST. Notice f9fc76447f484471aee6b54c90d5116d. https://sam.gov/workspace/contract/opp/f9fc76447f484471aee6b54c90d5116d/view
- December 11, 2024: Solicitation, due January 31, 2025 at 5:00 PM EST. Notice 8daece9056e94c82a49518012a315c84. https://sam.gov/workspace/contract/opp/8daece9056e94c82a49518012a315c84/view
- December 11, 2024: Solicitation, due January 31, 2025 at 5:00 PM EST. Notice b017ec84c41843348f2daf0145b34a43. https://sam.gov/workspace/contract/opp/b017ec84c41843348f2daf0145b34a43/view
- December 12, 2024: Solicitation, due January 31, 2025 at 5:00 PM EST. Notice 5d5a8adbd4104cc99575bcbe888b4c45. https://sam.gov/workspace/contract/opp/5d5a8adbd4104cc99575bcbe888b4c45/view
- January 13, 2025: Solicitation, due January 31, 2025 at 5:00 PM EST. Notice 0942f2241d01481a9d634c55655a591e. https://sam.gov/workspace/contract/opp/0942f2241d01481a9d634c55655a591e/view
- January 16, 2025: Solicitation, due February 14, 2025 at 5:00 PM EST. Notice f0b8597cceb4499a976874963338fd1d. https://sam.gov/workspace/contract/opp/f0b8597cceb4499a976874963338fd1d/view

## Points of contact

- CATALYST Email, CATALYST@arpa-h.gov

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/arpahsol24114.