MEX-AD:Clinical, epidemiological, & genetic characterization of Alzheimer's patients in the admixed Mexican population

The purpose of this requirement is to establish a multicentre cohort study in Mexico and characterize Alzheimer's disease (AD) patients' clinical, genetic, and phenotypic diversity in the admixed Mexican population, a group with unique genetic admixture and environmental exposures that is underrepresented in AD research. First, the Contractor shall determine the genetic substructure and familial contributions to AD in Mexico. This will advance efforts to treat AD in patients with rare mutations.

Second, by assembling this large cohort, the Contractor shall work to establish a preliminary Mexican-specific polygenic risk score (PRS) for predicting AD risk in future samples. Please see attached RFP titled "75N95024R00016 Solicitation" for the full solicitation. January 31, 2024 - RFP No. 75N95024R00016 has been amended. The Amendment 1 document is included. Note - The due date for proposal submission has CHANGED. Proposals are due at 3:00 PM Eastern Time on Monday, February 26, 2024.