# MEX-AD:Clinical, epidemiological, & genetic characterization of Alzheimer's patients in the admixed Mexican population

Canonical: https://abierto.us/opportunities/75n95024r00016

- Solicitation number: 75N95024R00016
- Notice type: Solicitation
- Status: Closed. Deadline was February 26, 2024 at 3:00 PM EST
- Department: Department of Health and Human Services
- Agency: National Institutes of Health
- Contracting office: National Institutes of Health Nida (75N950)
- NAICS: 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Product or service code: AN41 Health R&D Services; Health Care - Other; Basic Research
- Place of performance: MEX
- First posted: January 12, 2024
- Last posted: January 31, 2024
- SAM.gov: https://sam.gov/workspace/contract/opp/1fa3e59616ba4516b7714b8924bea0d1/view

## Description

The purpose of this requirement is to establish a multicentre cohort study in Mexico and characterize Alzheimer's disease (AD) patients' clinical, genetic, and phenotypic diversity in the admixed Mexican population, a group with unique genetic admixture and environmental exposures that is underrepresented in AD research. First, the Contractor shall determine the genetic substructure and familial contributions to AD in Mexico. This will advance efforts to treat AD in patients with rare mutations.

Second, by assembling this large cohort, the Contractor shall work to establish a preliminary Mexican-specific polygenic risk score (PRS) for predicting AD risk in future samples. Please see attached RFP titled "75N95024R00016 Solicitation" for the full solicitation. January 31, 2024 - RFP No. 75N95024R00016 has been amended. The Amendment 1 document is included. Note - The due date for proposal submission has CHANGED. Proposals are due at 3:00 PM Eastern Time on Monday, February 26, 2024.

## Publications

- January 12, 2024: Solicitation, due February 26, 2024 at 11:00 AM EST. Notice 1b764a9b2f7e4b26ba5c32dd61a1b2c5. https://sam.gov/workspace/contract/opp/1b764a9b2f7e4b26ba5c32dd61a1b2c5/view
- January 12, 2024: Solicitation, due February 26, 2024 at 11:00 AM EST. Notice 5c34183daf65415b9fbd085a2f49d8a7. https://sam.gov/workspace/contract/opp/5c34183daf65415b9fbd085a2f49d8a7/view
- January 31, 2024: Solicitation, due February 26, 2024 at 3:00 PM EST. Notice 1fa3e59616ba4516b7714b8924bea0d1. https://sam.gov/workspace/contract/opp/1fa3e59616ba4516b7714b8924bea0d1/view

## Points of contact

- Hashim Dasti, hashim.dasti@nih.gov, 3014028225
- Karen Mahon, karen.mahon@nih.gov, 3014357479

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/75n95024r00016.