Novel Antimalarial Drug Targets

Place of Performance: Contractor Facility The United States Army Medical Research Acquisition Activity (USAMRAA) intends to negotiate on a sole source basis IAW FAR 13.5 to Portland State University (PSU) 1600 SW 4th Ave. Portland, OR 97201 as the only responsible source that can provide Walter Reed Army institute of Research (WRAIR), Center for Infectious Disease Research (CIDR), Viral Diseases Branch (VDB) to support the investigation of Novel Antimalarial Drug Targets through affinity-based pulldowns.

Research efforts shall require chemistry expertise in compound WR936909 Structure-Activity Relationship (SAR) in order to produce probes and activity-based protein profiling. As well collaborator must be able to first test compounds and chemical probes in the Plasmodium asexual blood-stage assay before compounds and chemical probes are moved into the Plasmodium liver-stage model.