iNDI FA13.1J Cell Lines Expansion and Distribution for the iPSC Neurodegenerative Disease Initiative (iNDI) Project

SPECIAL NOTICE NOTICE OF INTENT TO AWARD A SOLE SOURCE CONTRACT Agency: Department of Health and Human Services (HHS), National Institutes of Health (NIH), National Institute on Aging (NIA)

Office: Center for Alzheimer’s Disease and Related Dementias (CARD)

Notice Type:

Special Notice Notice Number:

NIH-NOI-26-PCA-NIA-01205 Title: Notice of Intent to Sole Source – iNDI FA13.1J Cell Lines Expansion and Distribution for the iPSC Neurodegenerative Disease Initiative (iNDI)

Project NAICS Code: 325414 – Biological Product (except Diagnostic)

Manufacturing PSC: 6550 – In Vitro Diagnostic Substances, Reagents, Test Kits and Sets Description This is a notice of intent to award a sole source contract and is not a request for competitive quotations, proposals, or bids. The National Institute on Aging (NIA), Center for Alzheimer’s Disease and Related Dementias (CARD), intends to negotiate and award a firm-fixed-price contract to:

The Jackson Laboratory 600 Main Street Bar Harbor, ME 04609 UEI: XR6LMXNKDJJ1 for iNDI FA13.1J Cell Lines Expansion and Distribution for the iPSC Neurodegenerative Disease Initiative (iNDI) Project. The anticipated contract will provide for the expansion, quality control, curation, biobanking, and distribution of up to 936 isogenic Alzheimer’s disease and related dementias (ADRD) induced pluripotent stem cell (iPSC) lines in support of the iPSC Neurodegenerative Disease Initiative (iNDI). The requirement includes:

FA13.1J female SNV lines totaling 486 iPSC lines; 25 high-priority SNV trios across six additional iPSC lines totaling 450 iPSC lines; expansion and quality control in accordance with current iNDI protocols; product and web content creation for each iPSC line; and public distribution of cell lines through an established contractor-hosted website/platform. The statutory authority for this acquisition is 41 U.S.C.

1901, as implemented by FAR 13.501(a)(1)(ii), based on the circumstances described in FAR 6.302-1, Only One Responsible Source and No Other Supplies or Services Will Satisfy Agency Requirements. The Government’s market research included review of the prior sources sought notice posted on SAM.gov under Notice ID 75N95025Q00209-SBSS, review of prior NIH awards for similar iNDI requirements, and review of commercially available information regarding potential sources.

Based on that market research, The Jackson Laboratory is the only known source capable of providing the specific iNDI FA13.1J iPSC cell lines and associated expansion, quality control, curation, and distribution services required for this acquisition. The Jackson Laboratory also maintains the existing iNDI distribution infrastructure and has successfully performed prior related iNDI requirements for NIH.

Period of Performance Base Year: September 1, 2026 – August 31, 2027 Option Year 1: September 1, 2027 – August 31, 2028 Option Year 2: September 1, 2028 – August 31, 2029 Option Year 3: September 1, 2029 – August 31, 2030 Place of Performance The principal place of performance is the contractor’s facility. Responses This notice is not a solicitation. However, any responsible source that believes it can satisfy the Government’s requirement may submit a capability statement for the Government’s consideration.

Capability statements shall clearly demonstrate the ability to provide: the specific iNDI FA13.1J cell lines and associated iNDI lines required under this acquisition; expansion and quality control in accordance with current iNDI protocols; product and web content creation for each iPSC line; public distribution through an established contractor-hosted platform; and continuity sufficient to preserve comparability with existing iNDI resources and prior work.

Responses shall include, at a minimum: Company name UEI and CAGE Code, if applicable Business size and socioeconomic status Technical point of contact, including name, title, telephone number, and email address Narrative capability statement addressing the requirements above Relevant past performance information for similar efforts Responses must be submitted electronically to the point(s) of contact below no later than June 23, 2026, 11:00 am EST. Responses received after the stated deadline may not be considered.

The Government will review all timely responses solely for the purpose of determining whether to conduct a competitive procurement. A determination by the Government not to compete this requirement, based upon responses to this notice, is solely within the discretion of the Government. The Government will not be responsible for any costs incurred by respondents in preparing or submitting a response.

Point(s) of Contact Primary Point of Contact: Linda Smith, Contracting Officer, linda.smith2@nih.gov Secondary Point of Contact: Danielle Tines, Procurement Technician, danielle.tines@nih.gov