Infinium EPIC v2 Methylation Kits

Contractor Requirements: The vendor shall provide (4) Infinium Methylation EPIC v2 kits (96-sample kits)

Government Responsibilities: 2. At all times keep the genotyping kits will be stored in the environmental conditions recommended by the manufacturer. Use the genotyping kits in accordance with such instructions and recommendations relating to care and operation as may be issued by the manufacturer.

Background: The Center for Research on Genomics and Global Health is conducting a study to explore the differential methylation among a cohort of individuals using Illumina’s Infinium Methylation EPIC v2 beadchip kits.

Purpose and Objectives: This order is for methylation arrays produced and manufactured by Illumina. These beadchips are designed specifically for studying methylation changes across the genome. The methylation beadchips will be implemented as part of a study conducted by the Center for Research on Genomics and Global Health exploring methylation status of genes among participants previously recruited.

The methylation genotypes will be generated by the NHGRI Genomics Core which has the necessary equipment and expertise for efficient processing of Illumina SNP beadchips. The Core has an Illumina iScan, Illumina Autoloader, and a Tecan Liquid Handling Robot for automated processing of samples. This is a one-time-use product, and the genotyping is expected to be completed within 1-year.