Measuring mouse body composition

The National Institute of Diabetes and Digestive and Kidney Diseases requires an Whole Body Composition Analyzer to measure fat mass, lean mass, and body water in live mice. This system will replace an existing analyzer that is over 17 years old and no longer operational. The instrument provides rapid, non-invasive measurements in conscious animals without anesthesia, ensuring accurate and reproducible data.

It will be shared across multiple laboratories and is required to support ongoing research in obesity, diabetes, and related metabolic disorders.

The following product features/characteristics are required for this requirement: • Rapid scan time (~1–2 minutes per mouse) • No anesthesia requirement • High precision and reproducibility for fat and lean mass • Non-invasive, longitudinal measurement capability • Minimal operator variability • Validated performance in peer-reviewed metabolic research These features are essential for maintaining sympathetic tone and avoiding anesthetic-induced alterations in metabolic readouts, which is critical in acute drug response and metabolic studies.