Fully integrated dual YAG/SLT ophthalmic laser system with associated accessories

Statement of Need and Purpose: This acquisition is necessary to provide supplies and reagents to the Neurodegenerative Diseases Research Section for neurodegenerative disease research for proteomic analyses.

2. Background Information and Objective: Our project is focused on advancing our understanding of neurodegenerative diseases, particularly parkinsonism syndromes, through detailed analyses of human samples using state-of-the-art Olink Explore assays. By leveraging these assays, we will perform highresolution proteomics to map protein expression profiles across samples obtained from patients, thereby illuminating the complex molecular landscape of neurodegeneration.

3. Generic Name of Product: Human Olink Explore HT Assay Kit 4. Purchase Description: Item Description Cat no Quantity Total Cost Olink Explore HT Reagent Kit 98100 3 @ $68,800 ea $206,400.00 Shipping and Handling 0001-Shipping 1 @ $461.31 $461.31 Order Total $206,861.31 5. Salient characteristics. All deliverables required under this contract shall be packaged, marked, and shipped in accordance with Government specifications.

At a minimum, all deliverables shall be marked with the contract number and the Contractor's name. The Contractor shall guarantee that all required materials shall be delivered in an immediately usable and acceptable condition.

The vendor must be able to provide these specifications: • Must use an antibody-based approach to map protein abundance levels within samples. • Must provide the abundance levels for thousands of proteins within the samples. • Must be able to provide data that can be mapped to human biological pathways and processes that are potentially targetable by therapeutics.

6. Quantity: Item Description Cat no Quantity Total Cost Olink Explore HT Reagent Kit 98100 3 @ $68,800 ea $206,400.00 Shipping and Handling 0001-Shipping 1 @ $461.31 $461.31 Order Total $206,861.31