Imaris 10.2 for Neuroscientists (FL)

into the causes, treatment, and prevention of neurological disorders and stroke. The NINDS is a part of the National Institutes of Health (NIH), conducting research into the causes, treatment, and prevention of neurological disorders and stroke. The National Institute of Neurological Disorders and Stroke (NINDS) mission is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease.

The lab would hire outside assistance from various cellular analysis companies such as, Pathomics, to facilitate their cellular analysis. This costs the lab a lot of funding as well as time due to the slow return from these companies. The return on investment was not and will continue to not be as positive as doing the analysis ourselves here with the use of our own software. We currently have access to several confocal devices and are only lacking in the need for software to perform cellular analysis.

The DTAP lab has been investigating the BTB of high grade gliomas in young adults for several years now with many publications detailing various targets and pathways for potential therapeutics. For the past year, recent studies have increased to form a better understanding of the neighboring neuronal immune cells involved in the production of the BTB.

With a better understanding of the cellular interactions between glioma tumor cells and neuronal immune cells, targeted therapies can be developed in relation to specific cell types and their specific genes expressed. It is critical that we not only test drug delivery and development in the rat experimental model but also collect tissue for further investigation of the cellular interactions.

Temporospatial cues such as location and morphology are also crucial and beneficial factors to investigating immune-stained tissue. The IMARIS software will allow for us to analyze and quantify our findings thus leading to high impact journal publications. To continue to support cutting-edge research performed by the NIH scientific community, it is essential to acquire this software.