Notice of Intent: CUSTOM INDUCIBLE KNOCKIN MOUSE
\n\n(PCA-NIDDK-02527)
\n\nThe National Institutes of Health intends to award a Firm-Fixed-Price Purchase Order to Ingenious Targeting Laboratory Inc.
\n\nIn accordance with FAR Part 6.302-1, Ingenious Targeting Laboratory Inc is the only responsible source presently identified as capable of satisfying the complete technical requirements of this Custom Inducible Knockin Mouse.
\n\nThe Government determined that CRISPR/Cas9 and custom mouse-model generation services are available from multiple sources. However, the Government's requirement is for a specific endogenous Gcm2 genomic modification, rather than generic CRISPR/Cas9 mouse generation.
\n\nAlternative services offering Gcm2 expression through a heterologous promoter in a transgene do not satisfy this requirement because they do not modify the endogenous Gcm2 gene.
\n\nBased on the market research conducted to date, Ingenious Targeting Laboratory Inc. is the only responsible source identified as capable of satisfying the Government's complete technical requirement.
\n\nThis notice is not a request for competitive quotes. Ingenious Targeting Laboratory Inc. is the provider of CRISPR/Cas9 precision genomic-editing services specifically suited to the generation of the required Gcm2 knock-in mouse line this service. However, any available small businesses (e.g., 8(a), service-disabled veteran owned small business, HUBZone small business, small disadvantaged business, veteran-owned small business, and women-owned small business) as stated herein may submit a written capability statement that clearly supports and demonstrates their ability to perform the requirement. A determination by the Government to compete this proposed award based upon responses to this notice is solely within the discretion of the Government.
\n\nIt is anticipated that an award will be issued approximately five (5) days after the date of this notice unless the Government determines that another vendor has the capability to meet this requirement.
\n\nPlease email responses to vensonm@mail.nih.gov no later than 09:00 a.m. EDT on September 01, 2026.
","text":"Notice of Intent: CUSTOM INDUCIBLE KNOCKIN MOUSE\n\n(PCA-NIDDK-02527)\n\nThe National Institutes of Health intends to award a Firm-Fixed-Price Purchase Order to Ingenious Targeting Laboratory Inc.\n\nIn accordance with FAR Part 6.302-1, Ingenious Targeting Laboratory Inc is the only responsible source presently identified as capable of satisfying the complete technical requirements of this Custom Inducible Knockin Mouse.\n\nThe Government determined that CRISPR/Cas9 and custom mouse-model generation services are available from multiple sources. However, the Government's requirement is for a specific endogenous Gcm2 genomic modification, rather than generic CRISPR/Cas9 mouse generation.\n\nAlternative services offering Gcm2 expression through a heterologous promoter in a transgene do not satisfy this requirement because they do not modify the endogenous Gcm2 gene.\n\nBased on the market research conducted to date, Ingenious Targeting Laboratory Inc. is the only responsible source identified as capable of satisfying the Government's complete technical requirement.\n\nThis notice is not a request for competitive quotes. Ingenious Targeting Laboratory Inc. is the provider of CRISPR/Cas9 precision genomic-editing services specifically suited to the generation of the required Gcm2 knock-in mouse line this service. However, any available small businesses (e.g., 8(a), service-disabled veteran owned small business, HUBZone small business, small disadvantaged business, veteran-owned small business, and women-owned small business) as stated herein may submit a written capability statement that clearly supports and demonstrates their ability to perform the requirement. A determination by the Government to compete this proposed award based upon responses to this notice is solely within the discretion of the Government.\n\nIt is anticipated that an award will be issued approximately five (5) days after the date of this notice unless the Government determines that another vendor has the capability to meet this requirement.\n\nPlease email responses to vensonm@mail.nih.gov no later than 09:00 a.m. EDT on September 01, 2026.","origin":"detail"},"notice_type":{"code":"p","label":"Presolicitation"},"schema_version":1,"solicitation_number":"PCA-NIDDK-02527","place_of_performance":{"zip":"20892","city":{"code":"7125","name":"Bethesda"},"state":{"code":"MD","name":"Maryland"},"country":{"code":"USA","name":"UNITED STATES"}},"product_service_code":"6505"}],"due_at":"2026-09-01T13:00:00Z","due_date":"2026-09-01","closes_at":"2026-09-01T13:00:00Z","awardable":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N980","office_name":"NATIONAL INSTITUTES OF HEALTH OLAO","state":"MD","county":"24031","county_name":"Montgomery County","city":"2407125","city_name":"Bethesda","country":"USA","winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":true,"updated_at":"2026-09-17T06:28:38.602097Z","principal_notice_id":"1e35fa3ed66444d3a304fb9c51734c89","description":{"text":"Notice of Intent: CUSTOM INDUCIBLE KNOCKIN MOUSE\n\n(PCA-NIDDK-02527)\n\nThe National Institutes of Health intends to award a Firm-Fixed-Price Purchase Order to Ingenious Targeting Laboratory Inc.\n\nIn accordance with FAR Part 6.302-1, Ingenious Targeting Laboratory Inc is the only responsible source presently identified as capable of satisfying the complete technical requirements of this Custom Inducible Knockin Mouse.\n\nThe Government determined that CRISPR/Cas9 and custom mouse-model generation services are available from multiple sources. However, the Government's requirement is for a specific endogenous Gcm2 genomic modification, rather than generic CRISPR/Cas9 mouse generation.\n\nAlternative services offering Gcm2 expression through a heterologous promoter in a transgene do not satisfy this requirement because they do not modify the endogenous Gcm2 gene.\n\nBased on the market research conducted to date, Ingenious Targeting Laboratory Inc. is the only responsible source identified as capable of satisfying the Government's complete technical requirement.\n\nThis notice is not a request for competitive quotes. Ingenious Targeting Laboratory Inc. is the provider of CRISPR/Cas9 precision genomic-editing services specifically suited to the generation of the required Gcm2 knock-in mouse line this service. However, any available small businesses (e.g., 8(a), service-disabled veteran owned small business, HUBZone small business, small disadvantaged business, veteran-owned small business, and women-owned small business) as stated herein may submit a written capability statement that clearly supports and demonstrates their ability to perform the requirement. A determination by the Government to compete this proposed award based upon responses to this notice is solely within the discretion of the Government.\n\nIt is anticipated that an award will be issued approximately five (5) days after the date of this notice unless the Government determines that another vendor has the capability to meet this requirement.\n\nPlease email responses to vensonm@mail.nih.gov no later than 09:00 a.m. EDT on September 01, 2026.","html":"Notice of Intent: CUSTOM INDUCIBLE KNOCKIN MOUSE
\n\n(PCA-NIDDK-02527)
\n\nThe National Institutes of Health intends to award a Firm-Fixed-Price Purchase Order to Ingenious Targeting Laboratory Inc.
\n\nIn accordance with FAR Part 6.302-1, Ingenious Targeting Laboratory Inc is the only responsible source presently identified as capable of satisfying the complete technical requirements of this Custom Inducible Knockin Mouse.
\n\nThe Government determined that CRISPR/Cas9 and custom mouse-model generation services are available from multiple sources. However, the Government's requirement is for a specific endogenous Gcm2 genomic modification, rather than generic CRISPR/Cas9 mouse generation.
\n\nAlternative services offering Gcm2 expression through a heterologous promoter in a transgene do not satisfy this requirement because they do not modify the endogenous Gcm2 gene.
\n\nBased on the market research conducted to date, Ingenious Targeting Laboratory Inc. is the only responsible source identified as capable of satisfying the Government's complete technical requirement.
\n\nThis notice is not a request for competitive quotes. Ingenious Targeting Laboratory Inc. is the provider of CRISPR/Cas9 precision genomic-editing services specifically suited to the generation of the required Gcm2 knock-in mouse line this service. However, any available small businesses (e.g., 8(a), service-disabled veteran owned small business, HUBZone small business, small disadvantaged business, veteran-owned small business, and women-owned small business) as stated herein may submit a written capability statement that clearly supports and demonstrates their ability to perform the requirement. A determination by the Government to compete this proposed award based upon responses to this notice is solely within the discretion of the Government.
\n\nIt is anticipated that an award will be issued approximately five (5) days after the date of this notice unless the Government determines that another vendor has the capability to meet this requirement.
\n\nPlease email responses to vensonm@mail.nih.gov no later than 09:00 a.m. EDT on September 01, 2026.
","origin":"detail"},"contacts":[{"name":"MAI VENSON","role":"primary","email":"vensonm@mail.nih.gov"}],"place_of_performance":{"zip":"20892","city":{"code":"7125","name":"Bethesda"},"state":{"code":"MD","name":"Maryland"},"country":{"code":"USA","name":"UNITED STATES"}},"office_address":{"zip":"20892","city":"BETHESDA","state":"MD","country":"USA"},"naics_codes":["541714"],"award":null,"attachments":[],"awards":[],"related":[{"key":"75N98026Q01162","latest_notice_id":"407324c6677c4deb8a4f37ee5646f09c","title":"LI-COR Biosciences (LICORbio) for an Odyssey® M Imager","solicitation_number":"75N98026Q01162","notice_type":"p","first_type":"p","first_posted":"2026-09-08","last_posted":"2026-09-08","notices":1,"due_at":"2026-09-17T13:00:00Z","due_date":"2026-09-17","closes_at":"2026-09-17T13:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF 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