{"canonical":"https://abierto.us/opportunities/noinih6891599","key":"NOINIH6891599","url":"https://abierto.us/opportunities/noinih6891599","title":"Development of a Patient Derived RYR-1 Myopathy Model","solicitation_number":"NOINIH6891599","notice_type":"s","open":false,"response_deadline":"2024-02-23T15:00:00Z","first_posted":"2024-02-15","last_posted":"2024-02-15","department":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","subagency":"NATIONAL INSTITUTES OF HEALTH","office":"NATIONAL INSTITUTES OF HEALTH","naics":null,"psc":"R499","set_aside":"SBA","place_state":"MD","place_county":"24031","place_county_name":"Montgomery County","place_city":"2407125","place_city_name":"Bethesda","winner":null,"award_amount":null,"publications":[{"notice_id":"825acf5d81934dc28d1ca2759cc92ce7","title":"Development of a Patient Derived RYR-1 Myopathy Model","solicitation_number":"NOINIH6891599","notice_type":"s","base_type":"s","posted":"2024-02-15","posted_at":null,"due_at":"2024-02-23T15:00:00Z","due_date":"2024-02-23","cancelled":null,"archived":null,"archive_date":"2024-03-09","award_number":null,"awardee_name":null,"amount":null,"link_sam":"https://sam.gov/workspace/contract/opp/825acf5d81934dc28d1ca2759cc92ce7/view","enriched":false,"history":[]}],"latest_notice_id":"825acf5d81934dc28d1ca2759cc92ce7","first_type":"s","notices":[{"dates":{"posted":"2024-02-15","response_deadline":{"raw":"2024-02-23T10:00:00-05:00","utc":"2024-02-23T15:00:00Z","date":"2024-02-23","time":"10:00:00","utc_offset_seconds":-18000}},"links":{"sam":"https://sam.gov/workspace/contract/opp/825acf5d81934dc28d1ca2759cc92ce7/view"},"naics":{},"title":"Development of a Patient Derived RYR-1 Myopathy Model","agency":{"office":{"name":"NATIONAL INSTITUTES OF HEALTH"},"subtier":{"code":"7529","name":"NATIONAL INSTITUTES OF HEALTH"},"department":{"code":"075","name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF"},"office_address":{"zip":"20892","city":"Bethesda","state":"MD","country":"US"},"organization_type":"AGENCY"},"status":{"active":false,"archive_date":"2024-03-09","archive_type":"auto15"},"contacts":[{"name":"van v holley","role":"primary","email":"holleyv@od.nih.gov","phone":"3015949439"},{"name":"Sharmaine Fagan","role":"secondary","email":"sharmaine.fagan@nih.gov","phone":"3015943744"}],"base_type":{"code":"s","label":"Special Notice"},"notice_id":"825acf5d81934dc28d1ca2759cc92ce7","set_aside":{"code":"SBA","label":"Total Small Business Set-Aside (FAR 19.5)"},"provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/Archived%20Data/FY2024_archived_opportunities.csv","etag":"\"d582488fe153a9f11bf629913d176ffc-137\"","fetched_at":"2026-09-16T19:07:39.720164Z","row_sha256":"91d84a11d7829fbbb4d1cba844be757f0dc24e8a11caabfe2cbfd359d5c54dfe","last_modified":"2026-09-13T14:47:40Z"},"updated_at":"2026-09-16T19:07:39.720164Z","first_seen_at":"2026-09-16T19:07:39.720164Z"},"description":{"text":"This is a Notice of Intent, not a request for proposal. National Institute of Health (NIH)/National Institute of Nursing Research (NINR) intends to negotiate on an other than full and open competition basis with Hesperos, Inc. 12501 Research Parkway, Suite 100 Orlando, FL 32826, to provide provide Development of a Patient Derived RYR-1 Myopathy Model to Identify Disease Related Functional Deficits. The purpose of the procurement is for the vendor to develop a patient derived RYR-1 myopathy model using Hesperos’ Human-on-a-Chip micro-physiological systems. The Skeletal Muscle (SkM) model for RYR-1 associated myopathies will be developed by utilizing NIH-NINR sourced patient myoblasts and resultant myotubes for further downstream functional evaluation utilizing a Hesperos single-organ system. Patient cells will be evaluated for muscle function compared to healthy (Hesperos Sourced - ND41865) iPSC myoblasts. Myoblasts will be plated on silicon cantilever arrays and allow to fuse into myotubes to obtain contractile force measurements to identify SkM dysfunction associated with the RYR-1 myopathy phenotype. Scope Contractor will independently provide Development of a Patient Derived RYR-1 Myopathy Model to Identify Disease Related Functional Deficits. The statutory authority for this sole source requirement is 41 U.S.C. 253 (c) (1) as implemented by FAR 13.106-1 only one responsible source and no other supply of service will satisfy agency requirements. THIS IS NOT A SOLICITATION FOR COMPETITIVE QUOTATIONS. All responsible sources that could provide the required services may submit a capability statement that will be considered by email to Ms. Van Holley at holleyv@od.nih.gov by 10:00am eastern standard time Friday , February 23, 2024. All responses received by the closing date of this synopsis will be considered by the Government. A determination not to compete this requirement, based upon responses to this notice, is solely within the discretion of the Government.","origin":"extract"},"notice_type":{"code":"s","label":"Special Notice"},"schema_version":1,"solicitation_number":"NOINIH6891599","place_of_performance":{"zip":"20892","city":{"name":"Bethesda"},"state":{"code":"MD"},"country":{"code":"USA"}},"product_service_code":"R499"}],"due_at":"2024-02-23T15:00:00Z","due_date":"2024-02-23","closes_at":"2024-02-23T15:00:00Z","awardable":false,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-n-NATIONALINSTITUTESOFHEALTH","office_name":"NATIONAL INSTITUTES OF HEALTH","state":"MD","county":"24031","county_name":"Montgomery County","city":"2407125","city_name":"Bethesda","country":"USA","winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z","principal_notice_id":"825acf5d81934dc28d1ca2759cc92ce7","description":{"text":"This is a Notice of Intent, not a request for proposal. National Institute of Health (NIH)/National Institute of Nursing Research (NINR) intends to negotiate on an other than full and open competition basis with Hesperos, Inc. 12501 Research Parkway, Suite 100 Orlando, FL 32826, to provide provide Development of a Patient Derived RYR-1 Myopathy Model to Identify Disease Related Functional Deficits. The purpose of the procurement is for the vendor to develop a patient derived RYR-1 myopathy model using Hesperos’ Human-on-a-Chip micro-physiological systems. The Skeletal Muscle (SkM) model for RYR-1 associated myopathies will be developed by utilizing NIH-NINR sourced patient myoblasts and resultant myotubes for further downstream functional evaluation utilizing a Hesperos single-organ system. Patient cells will be evaluated for muscle function compared to healthy (Hesperos Sourced - ND41865) iPSC myoblasts. Myoblasts will be plated on silicon cantilever arrays and allow to fuse into myotubes to obtain contractile force measurements to identify SkM dysfunction associated with the RYR-1 myopathy phenotype. Scope Contractor will independently provide Development of a Patient Derived RYR-1 Myopathy Model to Identify Disease Related Functional Deficits. The statutory authority for this sole source requirement is 41 U.S.C. 253 (c) (1) as implemented by FAR 13.106-1 only one responsible source and no other supply of service will satisfy agency requirements. THIS IS NOT A SOLICITATION FOR COMPETITIVE QUOTATIONS. All responsible sources that could provide the required services may submit a capability statement that will be considered by email to Ms. Van Holley at holleyv@od.nih.gov by 10:00am eastern standard time Friday , February 23, 2024. All responses received by the closing date of this synopsis will be considered by the Government. A determination not to compete this requirement, based upon responses to this notice, is solely within the discretion of the Government.","html":null,"origin":"extract"},"contacts":[{"name":"van v holley","role":"primary","email":"holleyv@od.nih.gov","phone":"3015949439"},{"name":"Sharmaine Fagan","role":"secondary","email":"sharmaine.fagan@nih.gov","phone":"3015943744"}],"place_of_performance":{"zip":"20892","city":{"name":"Bethesda"},"state":{"code":"MD"},"country":{"code":"USA"}},"office_address":{"zip":"20892","city":"Bethesda","state":"MD","country":"US"},"naics_codes":[],"award":null,"attachments":[],"awards":[],"related":[]}