# Auto Droplet Generator

Canonical: https://abierto.us/opportunities/niddk07396

- Solicitation number: NIDDK07396
- Notice type: Special notice
- Status: Closed. Deadline was September 23, 2026 at 10:00 AM EDT
- Department: Department of Health and Human Services
- Contracting office: Department of Health and Human Services (n-HEALTHANDHUMANSERVICESDEPARTMENTOF)
- NAICS: 334516 Analytical Laboratory Instrument Manufacturing
- Product or service code: 6640 Laboratory Equipment and Supplies
- Place of performance: Bethesda, Maryland
- County: Montgomery County (FIPS 24031). https://abierto.us/counties/montgomery-county-md-24031
- City: Bethesda. https://abierto.us/cities/bethesda-md-2407125
- First posted: September 17, 2026
- Last posted: September 17, 2026
- SAM.gov: https://sam.gov/workspace/contract/opp/535b1fca363640b8bee58b102ad0e35c/view

## Description

The Diabetes Molecular Genetics Section of the Phoenix Epidemiology and Clinical Research Branch at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) studies pancreatic islet organoids derived from induced pluripotent stem cells to investigate molecular pathways associated with type 2 diabetes.

The laboratory recently acquired a QX600 Droplet Digital Polymerase Chain Reaction system to generate cell type-specific gene expression data, perform methylation analysis for epigenomic studies, and estimate pancreatic islet composition using cell type-specific marker genes. Currently, the laboratory uses a Manual Droplet Generator to prepare samples for droplet digital polymerase chain reaction analysis.

Although the system can process up to eight samples at a time, preparation of a full 96-well plate is time-consuming and relies heavily on manual pipetting. The Auto Droplet Generator shall automate droplet generation for droplet digital polymerase chain reaction workflows, reduce hands-on processing time, and improve throughput and consistency across experiments involving pancreatic islets and islet organoids.

## Publications

- September 17, 2026: Special notice, due September 23, 2026 at 10:00 AM EDT. Notice 535b1fca363640b8bee58b102ad0e35c. https://sam.gov/workspace/contract/opp/535b1fca363640b8bee58b102ad0e35c/view

## Points of contact

- Darin Mahkee, mahkeed@nih.gov

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/niddk07396.