# AN21 - Health Research and Developmental Services; Health Research and Training; Basic Research

Canonical: https://abierto.us/opportunities/n0018924qz406

- Solicitation number: N0018924QZ406
- Notice type: Combined synopsis and solicitation
- Status: Awarded to Davis University of California at
- Department: Department of the Navy
- Agency: Department of the Navy
- Contracting office: NAVSUP FLT Log CTR Norfolk (N00189)
- NAICS: 541720 Research and Development in the Social Sciences and Humanities
- Product or service code: AN21 Health R&D Services; Health Research And Training; Basic Research
- County: Southeastern Connecticut Planning Region (FIPS 09180). https://abierto.us/counties/southeastern-connecticut-planning-region-ct-09180
- City: Groton. https://abierto.us/cities/groton-ct-0934180
- First posted: August 10, 2024
- Last posted: August 10, 2024
- SAM.gov: https://sam.gov/workspace/contract/opp/2a32379cdd244f3885a313538f564529/view

## Description

The Naval Submarine Medical Research Laboratory (NSMRL) is interested in understanding the physiological responses to decompression stress. To that end, NSMRL plans to conduct dry hyperbaric experiments with up to 14 U.S. Navy divers as test subjects during which they will be exposed to a dive profile that is expected to produce venous gas emboli (VGE).

As VGE are filtered by the lungs, it is possible that biomarkers of this decompression stress may be evident in the exhaled breath of the divers following decompression. Thus, one of the primary aims of the NSMRL study entitled Applied Biomarkers of Decompression Stress is to identify substances in exhaled breath that are associated with decompression stress. To do this, NSMRL researchers will collect exhaled breath condensate (EBC) immediately before the dive and at two time points post-dive.

These EBC samples will be compared to a control condition in which the same divers breathe a normobaric nitrox gas mixture (with the PiO2 matched to the decompression dive) that will not produce any VGE. During both the decompression dive and the control condition, will also collect breath samples on thermal desorption tubes pre- and post-dive at the same time points, as well as gas sample controls to allow for analysis of the volatile organic compounds in exhaled breath.

NSMRL will be responsible for securing human use approval prior to conducting the study and will supply all EBC and VOC samples to the awarded contractor as de-identified coded samples. Description of tasks in attached synopsis.

## Award on USAspending

- Recipient: Davis University of California at (UEI ZCGHKT8CK366)
- Contract: N0018924PZ512, purchase order
- Obligated: $147,088.00
- Competition: Not Competed Under SAP, 1 offers received
- Link: solicitation number N0018924QZ406 equals the FPDS solicitation identifier; same awarding office N00189 (high confidence)
- Record: https://www.usaspending.gov/award/CONT_AWD_N0018924PZ512_9700_-NONE-_-NONE-/


## Publications

- August 10, 2024: Combined synopsis and solicitation, due August 12, 2024 at 12:00 PM EDT. Notice 2a32379cdd244f3885a313538f564529. https://sam.gov/workspace/contract/opp/2a32379cdd244f3885a313538f564529/view

## Points of contact

- Kimberly Mrasek 7573298608, kimberly.m.mrasek.civ@us.navy.mil

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Source: SAM.gov Contract Opportunities bulk extract and USAspending.gov award data. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/n0018924qz406.