# Broad-Spectrum Antagonists For Editors (B-SAFE)

Canonical: https://abierto.us/opportunities/hr001124s0032

- Solicitation number: HR001124S0032
- Notice type: Presolicitation
- Status: Closed. Deadline was August 12, 2024
- Department: Department of Defense
- Agency: Defense Advanced Research Projects Agency
- Contracting office: Def Advanced Research Projects Agcy (HR0011)
- NAICS: 541714 Research and Development in Biotechnology (except Nanobiotechnology)
- Product or service code: AC11 National Defense R&D Services; Department Of Defense - Military; Basic Research
- First posted: June 14, 2024
- Last posted: July 29, 2024
- SAM.gov: https://sam.gov/workspace/contract/opp/72a1b53fcf9d4a21a9993a728e2eb74d/view

## Description

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to identify and optimize novel molecules that exhibit inhibitory effects on Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR associated proteins (CRISPR-Cas) gene editing processes.

The Broad-Spectrum Antagonists for Editors (B-SAFE) program is explicitly seeking transformative approaches enabling the discovery or design of novel inhibitors of gene editing technologies with enhanced activity, utility, and breadth of coverage. Novel inhibitor activity will be assessed in vitro over the course of the program and a subset of top performing molecules will be selected for scale-up at quantities sufficient for testing and evaluation by Department of Defense (DoD) stakeholders.

In concert, DARPA is interested in exploring methods to rapidly discover inhibitor molecules for novel gene editing technologies beyond CRISPR-Cas systems to keep pace with the rapidly advancing field and promote the safe, controlled use of these technologies. Research that generates incremental improvements to the existing state-of-the-art are specifically excluded.

## Publications

- June 14, 2024: Presolicitation, due August 12, 2024. Notice 5f73920279b745a491b865013ad749c8. https://sam.gov/workspace/contract/opp/5f73920279b745a491b865013ad749c8/view
- July 3, 2024: Presolicitation, due August 12, 2024. Notice ce6396e6ca9c4f698ffee41fe4aa6f7f. https://sam.gov/workspace/contract/opp/ce6396e6ca9c4f698ffee41fe4aa6f7f/view
- July 29, 2024: Presolicitation, due August 12, 2024. Notice 72a1b53fcf9d4a21a9993a728e2eb74d. https://sam.gov/workspace/contract/opp/72a1b53fcf9d4a21a9993a728e2eb74d/view

## Points of contact

- BAA Coordinator, BSAFE@darpa.mil

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/hr001124s0032.