# Notice of Intent to Sole Source - ChromoLogic

Canonical: https://abierto.us/opportunities/hcccc202500493

- Solicitation number: HCCCC-2025-00493
- Notice type: Combined synopsis and solicitation
- Status: Closed. Deadline was January 8, 2025 at 9:00 AM EST
- Department: Department of Health and Human Services
- Agency: Centers for Disease Control and Prevention
- Contracting office: CDC Office of Acquisition Services (75D301)
- NAICS: 541990 All Other Professional, Scientific, and Technical Services
- Product or service code: AJ12 General Science And Technology R&D Services; General Science And Technology; Applied Research
- Place of performance: California
- County: Los Angeles County (FIPS 06037). https://abierto.us/counties/los-angeles-county-ca-06037
- First posted: December 30, 2024
- Last posted: December 30, 2024
- SAM.gov: https://sam.gov/workspace/contract/opp/50abea9d83f948b9acf6926a924ea126/view

## Description

Collaboration with vendor is needed to evaluate our existing test samples from rats exposed to silica-containing, engineered stone dusts. Predictive algorithms are needed for pre-sympomatic pulmonary fibrosis, and we will need to be able to partner with the vendor to test whether existing predictive models for pre-symptomatic radiation-induced pulmonary fibrosis are useful for silica-induced fibrosis by using their proprietary algorithms. Samples that will be shipped to the vendor.

The vendor will need to be able to evaluate them according to a well-established workflow for miRNA analysis and bioinformatic analysis.They will evaluate plasma sample acceptability and perform miRNA extraction, sequencing, and analysis.

They will then evaluate the results obtained to determine comparability to existing circulating miRNA-based fibrosis signatures using proprietary algorithms based on bioinformatic analyses using both Gene Ontology (GO) and Kyoto Encycolpdeia of Genes and Genomes (KEGG) evaluations that have been integrated into a computational, predictive model of pre-symptomatic radiation-induced fibrosis that uses the relative expression of miRNA found in extracellular vescicles of circulating plasmsa in exposed animals.

They will use their proprietary predictive model of pre-symptomatic radiation-induced pulmonary fibrosis to determine how useful it is in detecting pre-symptomatic silica-induced pulmonary fibrosis by evaluating the positive predictive value among those samples tested.

## Publications

- December 30, 2024: Combined synopsis and solicitation, due January 8, 2025 at 9:00 AM EST. Notice 50abea9d83f948b9acf6926a924ea126. https://sam.gov/workspace/contract/opp/50abea9d83f948b9acf6926a924ea126/view

## Points of contact

- Kathryn Green, ezj7@cdc.gov, 4046396470

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/hcccc202500493.