# Request for Information: Biomolecule Purification

Canonical: https://abierto.us/opportunities/darpasn2666

- Solicitation number: DARPA-SN-26-66
- Notice type: Special notice
- Status: Closed. Deadline was June 8, 2026
- Department: Department of Defense
- Agency: Defense Advanced Research Projects Agency
- Contracting office: Def Advanced Research Projects Agcy (HR0011)
- NAICS: 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Product or service code: AC12 National Defense R&D Services; Department Of Defense - Military; Applied Research
- First posted: May 15, 2026
- Last posted: May 21, 2026
- SAM.gov: https://sam.gov/workspace/contract/opp/b8e73bf9adcb4c62a0da544d64795ef9/view

## Description

The Defense Advanced Research Projects Agency (DARPA) Multi X Office (MXO) seeks information on novel methods for the purification of large complex molecules that will enable the creation of a universal purification platform capable of separating and recovering multiple large and complex molecules with high specificity, purity, and yield from complex feedstock.

It is anticipated that such a platform will decrease the time and complexity of purification and eliminate the need for multistep chromatography processes, which DARPA believes to be the state of the art.

In addition, this RFI seeks to understand a) the current advances and challenges in the purification of biologically produced proteins, as well as of other critical biologically produced molecules that could benefit from a novel purification approach, and b) new operational capabilities enabled by novel purification approaches. Responses to this RFI will be used to inform the development of a new program.

## Publications

- May 15, 2026: Special notice, due June 8, 2026. Notice e69e8e0fd537432f81d23cf4d38faee5. https://sam.gov/workspace/contract/opp/e69e8e0fd537432f81d23cf4d38faee5/view
- May 21, 2026: Special notice, due June 8, 2026. Notice b8e73bf9adcb4c62a0da544d64795ef9. https://sam.gov/workspace/contract/opp/b8e73bf9adcb4c62a0da544d64795ef9/view

## Points of contact

- DARPA-SN-26-66 Coordinator, DARPA-SN-26-66@darpa.mil

---
Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/darpasn2666.