# Physics-Based Control Over de novo Synthesis of DNA or RNA

Canonical: https://abierto.us/opportunities/darpasn2546

- Solicitation number: DARPA-SN-25-46
- Notice type: Special notice
- Status: Closed. Deadline was March 20, 2025 at 4:00 PM EDT
- Department: Department of Defense
- Agency: Defense Advanced Research Projects Agency
- Contracting office: Def Advanced Research Projects Agcy (HR0011)
- NAICS: 541714 Research and Development in Biotechnology (except Nanobiotechnology)
- Product or service code: AC11 National Defense R&D Services; Department Of Defense - Military; Basic Research
- Place of performance: Arlington, Virginia
- County: Arlington County (FIPS 51013). https://abierto.us/counties/arlington-county-va-51013
- City: Arlington. https://abierto.us/cities/arlington-va-5103000
- First posted: February 14, 2025
- Last posted: February 14, 2025
- SAM.gov: https://sam.gov/workspace/contract/opp/bd7c123684854471abc45fa68a6237a6/view

## Description

The Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO) seeks to gain a better understanding of biotechnological advancements and gaps that could contribute to the ability to synthesize de novo DNA and RNA sequences in vivo.

The goal of this RFI is to gather information on the possibility and challenges in developing a platform for in vivo (i.e., in a living cell) synthesis of DNA/RNA, where the nucleic acid sequence is precisely defined by patterns of physical stimulation (i.e., optical, mechanical, sound, electrical, thermal, etc.) rather than using a DNA/RNA template strand.

The ultimate aim is for this template-free, de novo synthesis (i.e., capable of producing arbitrary sequences that may not be based on natural sequences) mechanism to produce DNA/RNA that can be translated into functional proteins.

## Publications

- February 14, 2025: Special notice, due March 20, 2025 at 4:00 PM EDT. Notice bd7c123684854471abc45fa68a6237a6. https://sam.gov/workspace/contract/opp/bd7c123684854471abc45fa68a6237a6/view

## Points of contact

- BAA Coordinator, DARPA-SN-25-46@darpa.mil

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