# Virtual-Integrated Twin for Autonomous Lifesaving (VITAL)

Canonical: https://abierto.us/opportunities/darpaps2626

- Solicitation number: DARPA-PS-26-26
- Notice type: Solicitation
- Status: Closed. Deadline was June 25, 2026
- Department: Department of Defense
- Agency: Defense Advanced Research Projects Agency
- Contracting office: Def Advanced Research Projects Agcy (HR0011)
- NAICS: 541714 Research and Development in Biotechnology (except Nanobiotechnology)
- Product or service code: AC12 National Defense R&D Services; Department Of Defense - Military; Applied Research
- First posted: April 9, 2026
- Last posted: April 21, 2026
- SAM.gov: https://sam.gov/workspace/contract/opp/3e66d960c0a14d51b236bbcf712d34cf/view

## Description

**UPDATE:** The purpose of Amendment 1 to DARPA-PS-26-26, the Virtual-Integrated Twin for Autonomous Lifesaving (VITAL) Program Solicitation (PS), is to clarify the proposal abstract questions deadline and the 7-page proposal abstract section requirements.

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative approaches to address challenges in developing continuously updating digital twin models of the cardiovascular system that combine patient data with biological physics to simulate in real time possible interventions and to predict their outcomes before actual intervention on a patient.

The VITAL program will establish a foundation for causal, prediction-driven decision support in medicine, enabling clinicians and future autonomous systems to evaluate treatment options before they are applied. By defining when mechanistic digital twins, reduced-order models, and data-driven inference are reliable and actionable, VITAL will shift medical care from reactive assessment to anticipatory intervention. This capability has the potential to improve outcomes across acute, chronic, and emergent clinical settings.

## Publications

- April 9, 2026: Solicitation, due June 25, 2026. Notice 5c6a433f8f6c4965a787ef4a01191d72. https://sam.gov/workspace/contract/opp/5c6a433f8f6c4965a787ef4a01191d72/view
- April 21, 2026: Solicitation, due June 25, 2026. Notice 3e66d960c0a14d51b236bbcf712d34cf. https://sam.gov/workspace/contract/opp/3e66d960c0a14d51b236bbcf712d34cf/view

## Points of contact

- Dr. Roozbeh Jafari, Program Manager, DARPA/BTO, VITAL@darpa.mil

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/darpaps2626.