# High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

Canonical: https://abierto.us/opportunities/darpapa2701

- Solicitation number: DARPA-PA-27-01
- Notice type: Solicitation
- Status: Open. Offers due November 5, 2026
- Department: Department of Defense
- Agency: Defense Advanced Research Projects Agency
- Contracting office: Def Advanced Research Projects Agcy (HR0011)
- NAICS: 541714 Research and Development in Biotechnology (except Nanobiotechnology)
- Product or service code: AC12 National Defense R&D Services; Department Of Defense - Military; Applied Research
- Who can bid, by location: Anywhere in the US. Location does not limit who can bid: a product shipped to the buyer, research at the performer's facility, or work at the contractor's site. A state shown is the delivery point.
- First posted: October 8, 2026
- Last posted: October 8, 2026
- SAM.gov: https://sam.gov/workspace/contract/opp/98c034706e4b430281ead1c3497e9d72/view

## Description

The Defense Advanced Research Projects Agency (DARPA) is soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions. Utility of this capability will be demonstrated in identifying novel diagnostic and therapeutic targets within the interaction space underlying including traumatic brain injury.

## Attachments

- [Attachment_A_Abstract_Template_and_Instructions__Phase_1_.docx](https://sam.gov/api/prod/opps/v3/opportunities/resources/files/c716629e1cff4652ad8a1a9b775ff4cc/download)

## Open now in the same industry

14 open in NAICS 541714.

- AMPLICON SEQUENCING SERVICES (140G0226Q0047), due November 5, 2026 at 2:30 PM EST. https://abierto.us/opportunities/140g0226q0047
- Firefox (DARPA-PS-26-137), due November 9, 2026. https://abierto.us/opportunities/darpaps26137
- Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS) (ARPA-H-SOL-26-164), due November 30, 2026 at 5:00 PM EST. https://abierto.us/opportunities/arpahsol26164

## Publications

- October 8, 2026: Solicitation, due November 5, 2026. Notice 98c034706e4b430281ead1c3497e9d72. https://sam.gov/workspace/contract/opp/98c034706e4b430281ead1c3497e9d72/view

## Points of contact

- Dr. Abhishek Singharoy, DARPA/BTO, HUBBLE@darpa.mil

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/darpapa2701.