# One Comprehensive Universal Radiotherapy for Everyone (1-CURE)

Canonical: https://abierto.us/opportunities/arpahsol26147

- Solicitation number: ARPA-H-SOL-26-147
- Notice type: Solicitation
- Status: Closed. Deadline was May 22, 2026 at 11:59 PM EDT
- Department: Department of Health and Human Services
- Agency: National Institutes of Health
- Contracting office: Advanced Research Projects Agency for Health (Arpa-H) (75N992)
- NAICS: 541714 Research and Development in Biotechnology (except Nanobiotechnology)
- Product or service code: AN13 Health R&D Services; Health Care Services; Experimental Development
- First posted: March 16, 2026
- Last posted: May 4, 2026
- SAM.gov: https://sam.gov/workspace/contract/opp/359c81244add413d86463d02643e5707/view

## Description

**Amendment 4:**

**Revised Appendix B:** Full Proposal Content and Instructions to consistently state that Volume I, Element H is the Target Product Profiles (TPP). Appendix B Volume I, Element I was renamed to Milestone Payment Schedule (MPS) and clarifies that the provided format in Appendix I, Attachment 3 is to be used. Appendix B Volume II Cost and Pricing Data Support page limit was removed.

**Appendix L:** Cost Proposal Spreadsheet with Resource Sharing has been added to the attachments.

**Amendment 3:**

**Revised Appendix F:** Administrative & National Policy Requirements Document, Section 3, Paragraph 1, to state that the Biographical Common Form, the Current and Pending (other) Support Common Form, and the Collaborators and Other Affiliations attachments may be provided during the negotiation phase after proposal selection.

**Amendment 2:** Added Appendices J & K under the Attachments section.

**Amendment 1:** Added Appendices A - I separately under the Attachments section. The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) in support of the One Comprehensive Universal Radiotherapy for Everyone (1-CURE) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from this announcement.

Interested parties are invited to review the attached 1-CURE_ISO_ARPA-H-SOL-26-147 and its Appendices A - C. Additionally, proposers are encouraged to review the separate Special Notice, ARPA-H-SN-26-152, for information regarding the 1-CURE Proposers’ Day. Special Notice, ARPA-H-SN-26-152, is an independent announcement and is not attached to this ISO announcement. All questions submitted to the ISO will be compiled and addressed. All answers will be posted to the 1-CURE Frequently Asked Questions (FAQ) page. Potential proposers are encouraged to monitor the FAQs page regularly for the latest information and updates: https://arpa-h.gov/explore-funding/programs/1-cure/faqs

## Publications

- March 16, 2026: Solicitation, due May 22, 2026 at 11:59 PM EDT. Notice 9ab23f65e4ed4406831a74a3daba0279. https://sam.gov/workspace/contract/opp/9ab23f65e4ed4406831a74a3daba0279/view
- April 14, 2026: Solicitation, due May 22, 2026 at 11:59 PM EDT. Notice 98960e4bca3e47cb827fa332151f5daa. https://sam.gov/workspace/contract/opp/98960e4bca3e47cb827fa332151f5daa/view
- April 16, 2026: Solicitation, due May 22, 2026 at 11:59 PM EDT. Notice 04a66f55124f4020891144571ccf2a38. https://sam.gov/workspace/contract/opp/04a66f55124f4020891144571ccf2a38/view
- April 29, 2026: Solicitation, due May 22, 2026 at 11:59 PM EDT. Notice 80de1ccda4df4672ab6003fa7989f11b. https://sam.gov/workspace/contract/opp/80de1ccda4df4672ab6003fa7989f11b/view
- May 4, 2026: Solicitation, due May 22, 2026 at 11:59 PM EDT. Notice 359c81244add413d86463d02643e5707. https://sam.gov/workspace/contract/opp/359c81244add413d86463d02643e5707/view

## Points of contact

- The 1-CURE Team, 1-CURE@ARPA-H.GOV

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/arpahsol26147.