# Treating Hereditary Rare Diseases With In Vivo Precision Genetic Medicines (THRIVE)

Canonical: https://abierto.us/opportunities/arpahsn25131

- Solicitation number: ARPA-H-SN-25-131
- Notice type: Special notice
- Status: Closed. Deadline was October 2, 2025 at 8:59 AM EDT
- Department: Department of Health and Human Services
- Agency: National Institutes of Health
- Contracting office: Advanced Research Projects Agency for Health (Arpa-H) (75N992)
- NAICS: 541714 Research and Development in Biotechnology (except Nanobiotechnology)
- Product or service code: AN13 Health R&D Services; Health Care Services; Experimental Development
- Place of performance: Washington, District of Columbia
- County: District of Columbia (FIPS 11001). https://abierto.us/counties/district-of-columbia-dc-11001
- City: Washington. https://abierto.us/cities/washington-dc-1150000
- First posted: September 25, 2025
- Last posted: October 1, 2025
- SAM.gov: https://sam.gov/workspace/contract/opp/6b7827d3aa4a4a998fe255808dbb8b86/view

## Description

The purpose of this amendment is to:

1. Extend the registration deadline for lightning talks and sidebars to October 2, 2025 at 08:59AM ET.

2. Extend the available days/hours for lightning talks and sidebars. Lightning talks and sidebars slots will now be available on October 3. 2025. Slots for the October 3rd lightning talks and sidebars will be available between 11:00AM ET to 2:00PM ET. In addition, slots for the October 2nd sidebars will now be available between 11:00AM ET and 7:00PM ET. Please see the revised Special Notice document for additional details.

This Special Notice (SN) is intended to alert the scientific community to a newly approved ARPA-H Program and notify potential proposers of an associated Proposers’ Day (PD). Under the cognizance of HSF, ARPA-H is publishing an Innovative Solutions Opening (ISO) for the Treating Hereditary Rare diseases with In Vivo precision genetic mEdicines (THRIVE) program no later than September 25, 2025, please monitor SAM.gov for updates (ARPA-H-SOL-25-122). For additional PD details and registration information see the attached special notice (ARPA-H-SN-25-131). For more information about the THRIVE program visit: https://arpa-h.gov/explore-funding/programs/thrive

## Publications

- September 25, 2025: Special notice, due September 30, 2025 at 11:59 PM EDT. Notice 158c111f6a0d4952b97419c6dccc068c. https://sam.gov/workspace/contract/opp/158c111f6a0d4952b97419c6dccc068c/view
- October 1, 2025: Special notice, due October 2, 2025 at 8:59 AM EDT. Notice 6b7827d3aa4a4a998fe255808dbb8b86. https://sam.gov/workspace/contract/opp/6b7827d3aa4a4a998fe255808dbb8b86/view

## Points of contact

- THRIVE Program, THRIVE@arpa-h.gov

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/arpahsn25131.