# Effect of Radiation Quality and Galactic Cosmic Radiation Simulation on the Risk of Carcinogenesis in an Outbred Mouse Model (HS/Npt)

Canonical: https://abierto.us/opportunities/80jsc025irm001

- Solicitation number: 80JSC025IRM001
- Notice type: Sources sought
- Status: Closed. Deadline was September 18, 2025 at 2:00 PM EDT
- Department: National Aeronautics and Space Administration
- Contracting office: NASA Johnson Space Center (80JSC0)
- NAICS: 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Place of performance: Houston, Texas
- City: Houston. https://abierto.us/cities/houston-tx-4835000
- First posted: September 11, 2025
- Last posted: September 11, 2025
- SAM.gov: https://sam.gov/workspace/contract/opp/b03bb5580cbb4a67bfeec8f7844e7cd1/view

## Description

1. Background Astronauts on long-duration space missions are exposed to galactic cosmic rays (GCR) and solar particle events (SPE), creating elevated risks of carcinogenesis, cardiovascular disease (CVD), and central nervous system (CNS) decrements. Traditional inbred animal models have limitations due to genetic uniformity, potentially leading to overestimation of relative biological effectiveness (RBE). Outbred mouse models (HS/Npt) provide a genetically diverse system that better mirrors human populations and may yield more accurate assessments of radiation-induced cancer and related health risks.

2. Objectives The objectives of this study are to:

1. Determine the effects of radiation quality, dose, and dose rate on cancer initiation, promotion, and progression in HS/Npt outbred mice.

2. Establish RBEs and quality factor estimates for space-relevant radiation exposures.

3. Provide biobanked tissue and comprehensive metadata to support future NASA investigations.

4. (Optional) Assess cardiovascular and CNS outcomes, as well as sex-specific responses, within budget constraints. 3. Scope of Work The Principal Investigator (PI) shall design and execute experiments utilizing outbred HS/Npt mice supplied by NASA. Work shall include:

- Radiation exposures at technically acceptable laboratory (See attached laboratory technical acceptability requirements sheet), including gamma irradiation, full GCR simulation (acute and fractionated), and single-ion exposures (e.g., 56Fe) where justified. - Dose coverage relevant to Mars design reference missions (300–450 mGy). - Survival, tumor incidence, and tumor spectrum analyses. - Comprehensive tissue collection, preservation, and metadata management. - Biobanking of required samples per NASA specifications. - Preparation of interim and final reports. This is stricly a request for information. The Government has no obligation for award. If interested please provide a capabilities statement.

## Publications

- September 11, 2025: Sources sought, due September 18, 2025 at 2:00 PM EDT. Notice b03bb5580cbb4a67bfeec8f7844e7cd1. https://sam.gov/workspace/contract/opp/b03bb5580cbb4a67bfeec8f7844e7cd1/view

## Points of contact

- Joshua Hlavenka, joshua.r.hlavenka@nasa.gov
- Katelyn Jaime, katelyn.r.jaime@nasa.gov

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/80jsc025irm001.