{"canonical":"https://abierto.us/opportunities/75n98026r00085","key":"75N98026R00085","url":"https://abierto.us/opportunities/75n98026r00085","title":"The Therapeutic Role of Soluble Adenylyl Cyclase Inhibition in Ameliorating Inflammatory Vascular Remodeling in Pulmonary Arterial Hypertension","solicitation_number":"75N98026R00085","notice_type":"s","open":false,"response_deadline":"2026-06-18T20:00:00Z","first_posted":"2026-06-04","last_posted":"2026-09-14","department":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","subagency":"NATIONAL INSTITUTES OF HEALTH","office":"NATIONAL INSTITUTE OF HEALTH NIH-OD","naics":"541715","psc":"AN12","set_aside":"SBA","place_state":"IL","place_county":"17031","place_county_name":"Cook County","place_city":"1714000","place_city_name":"Chicago","winner":null,"award_amount":null,"publications":[{"notice_id":"adfd909f33094919925b63daff11cf84","title":"NHLBI Innovation and Commercialization Ecosystem: Product Development Support and Program Evaluation","solicitation_number":"75N98026R00085","notice_type":"r","base_type":"r","posted":"2026-06-04","posted_at":null,"due_at":"2026-06-18T20:00:00Z","due_date":"2026-06-18","cancelled":null,"archived":null,"archive_date":"2026-07-03","award_number":null,"awardee_name":null,"amount":null,"link_sam":"https://sam.gov/workspace/contract/opp/adfd909f33094919925b63daff11cf84/view","enriched":false,"history":[]},{"notice_id":"955c40f8d97c42e081a4c82c09bdb80c","title":"The Therapeutic Role of Soluble Adenylyl Cyclase Inhibition in Ameliorating Inflammatory Vascular Remodeling in Pulmonary Arterial Hypertension","solicitation_number":"75N98026R00085","notice_type":"s","base_type":"s","posted":"2026-09-14","posted_at":null,"due_at":"2026-09-21T16:00:00Z","due_date":"2026-09-21","cancelled":null,"archived":null,"archive_date":"2026-10-06","award_number":null,"awardee_name":null,"amount":null,"link_sam":"https://sam.gov/workspace/contract/opp/955c40f8d97c42e081a4c82c09bdb80c/view","enriched":false,"history":[]}],"latest_notice_id":"955c40f8d97c42e081a4c82c09bdb80c","first_type":"r","notices":[{"dates":{"posted":"2026-06-04","response_deadline":{"raw":"2026-06-18T16:00:00-04:00","utc":"2026-06-18T20:00:00Z","date":"2026-06-18","time":"16:00:00","utc_offset_seconds":-14400}},"links":{"sam":"https://sam.gov/workspace/contract/opp/adfd909f33094919925b63daff11cf84/view"},"naics":{"codes":["541611"],"primary":"541611"},"title":"NHLBI Innovation and Commercialization Ecosystem: Product Development Support and Program Evaluation","agency":{"office":{"code":"75N920","name":"NATIONAL INSTITUTES OF HEALTH NHLBI"},"subtier":{"code":"7529","name":"NATIONAL INSTITUTES OF HEALTH"},"department":{"code":"075","name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF"},"office_address":{"zip":"20892","city":"BETHESDA","state":"MD","country":"USA"},"organization_type":"OFFICE"},"status":{"active":false,"archive_date":"2026-07-03","archive_type":"auto15"},"contacts":[{"name":"Henselmann, Jennifer","role":"primary","email":"jennifer.henselmann@nih.gov","phone":"301-827-7547"},{"name":"Donna Cornish","role":"secondary","email":"donna.cornish@nih.gov"}],"base_type":{"code":"r","label":"Sources Sought"},"notice_id":"adfd909f33094919925b63daff11cf84","set_aside":{"code":"SBA","label":"Total Small Business Set-Aside (FAR 19.5)"},"provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/Archived%20Data/FY2026_archived_opportunities.csv","etag":"\"d9374b90a938e9923d910594731b7b57-106\"","fetched_at":"2026-09-16T16:22:53.920682Z","row_sha256":"eac3d2214c7b10f97089fc3f8665f4395cd67168ed4e934974abab5ca462d475","last_modified":"2026-09-13T14:50:39Z"},"updated_at":"2026-09-16T16:22:53.920682Z","first_seen_at":"2026-09-16T16:22:53.920682Z"},"description":{"text":"The National Heart, Lung, and Blood Institute (NHLBI), Innovation and Commercialization Office (I&C), is conducting market research to identify qualified small business sources capable of providing innovation and commercialization ecosystem support services. The anticipated requirement includes program evaluation and analytics, partner engagement and commercialization support, operation and enhancement of an AI-enabled partnering platform, program coordination and logistics, entrepreneurial education and mentoring, and support for Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) initiatives. The Government is seeking capability statements from small business concerns capable of performing the activities described in the attached draft Statement of Work. Responses will be used for acquisition planning purposes, including assessing the availability of qualified small business sources and determining an appropriate acquisition strategy. (See additional details in the attached Sources Sought Notice)","origin":"extract"},"notice_type":{"code":"r","label":"Sources Sought"},"schema_version":1,"solicitation_number":"75N98026R00085","place_of_performance":{"city":{"name":"Bethesda"},"state":{"code":"MD"},"country":{"code":"USA"}},"product_service_code":"R408"},{"dates":{"posted":"2026-09-14","response_deadline":{"raw":"2026-09-21T12:00:00-04:00","utc":"2026-09-21T16:00:00Z","date":"2026-09-21","time":"12:00:00","utc_offset_seconds":-14400}},"links":{"sam":"https://sam.gov/workspace/contract/opp/955c40f8d97c42e081a4c82c09bdb80c/view"},"naics":{"codes":["541715"],"primary":"541715"},"title":"The Therapeutic Role of Soluble Adenylyl Cyclase Inhibition in Ameliorating Inflammatory Vascular Remodeling in Pulmonary Arterial Hypertension","agency":{"office":{"code":"75N98E","name":"NATIONAL INSTITUTE OF HEALTH NIH-OD"},"subtier":{"code":"7529","name":"NATIONAL INSTITUTES OF HEALTH"},"department":{"code":"075","name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF"},"office_address":{"zip":"20892","city":"BETHESDA","state":"MD","country":"USA"},"organization_type":"OFFICE"},"status":{"active":true,"archive_date":"2026-10-06","archive_type":"auto15"},"contacts":[{"name":"Donna Cornish","role":"primary","email":"donna.cornish@nih.gov"}],"base_type":{"code":"s","label":"Special Notice"},"notice_id":"955c40f8d97c42e081a4c82c09bdb80c","provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/datagov/ContractOpportunitiesFullCSV.csv","etag":"\"c558e51a98eafa51835c4498e56c17e1-29\"","fetched_at":"2026-09-17T03:34:20.822145964Z","row_sha256":"888d4e0115d965c86c98d63f2890335e9ddcb5834ca74e300ca23be66a95fdfb","last_modified":"2026-09-17T03:30:47Z"},"updated_at":"2026-09-17T03:34:20.822145964Z","first_seen_at":"2026-09-15T22:52:52.472456Z"},"description":{"text":"The National Institutes of Health (NIH) intends to negotiate on a sole-source basis with the University of Illinois at Chicago (UIC) for preclinical animal research services to evaluate the therapeutic effects of soluble adenylyl cyclase (sAC) inhibition on pulmonary arterial hypertension (PAH) using an established endothelial cell-specific Cav1 knockout (EC-Cav1 KO) murine model and corresponding wild-type controls. The Government intends to solicit from a single source pursuant to FAR 13.106-1(b)(1). UIC currently maintains the established EC-Cav1 KO mouse colony required for this study, and the model is not known to be maintained by another laboratory. This notice of intent is not a request for competitive quotations. However, all responsible sources that believe they can satisfy the Government's requirements may submit a capability statement and/or quotation for consideration by the Government. Please see the attached Notice of Intent to Sole Source for the complete description of the requirement, basis for the intended sole-source acquisition, response instructions, and applicable response deadline.","origin":"extract"},"notice_type":{"code":"s","label":"Special Notice"},"schema_version":1,"solicitation_number":"75N98026R00085","place_of_performance":{"zip":"60607","city":{"name":"Chicago"},"state":{"code":"IL"},"country":{"code":"USA"}},"product_service_code":"AN12"}],"due_at":"2026-06-18T20:00:00Z","due_date":"2026-06-18","closes_at":"2026-06-18T20:00:00Z","awardable":false,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N98E","office_name":"NATIONAL INSTITUTE OF HEALTH NIH-OD","state":"IL","county":"17031","county_name":"Cook County","city":"1714000","city_name":"Chicago","country":"USA","winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-17T06:28:38.602097Z","principal_notice_id":"955c40f8d97c42e081a4c82c09bdb80c","description":{"text":"The National Institutes of Health (NIH) intends to negotiate on a sole-source basis with the University of Illinois at Chicago (UIC) for preclinical animal research services to evaluate the therapeutic effects of soluble adenylyl cyclase (sAC) inhibition on pulmonary arterial hypertension (PAH) using an established endothelial cell-specific Cav1 knockout (EC-Cav1 KO) murine model and corresponding wild-type controls. The Government intends to solicit from a single source pursuant to FAR 13.106-1(b)(1). UIC currently maintains the established EC-Cav1 KO mouse colony required for this study, and the model is not known to be maintained by another laboratory. This notice of intent is not a request for competitive quotations. However, all responsible sources that believe they can satisfy the Government's requirements may submit a capability statement and/or quotation for consideration by the Government. Please see the attached Notice of Intent to Sole Source for the complete description of the requirement, basis for the intended sole-source acquisition, response instructions, and applicable response deadline.","html":null,"origin":"extract"},"contacts":[{"name":"Donna Cornish","role":"primary","email":"donna.cornish@nih.gov"}],"place_of_performance":{"zip":"60607","city":{"name":"Chicago"},"state":{"code":"IL"},"country":{"code":"USA"}},"office_address":{"zip":"20892","city":"BETHESDA","state":"MD","country":"USA"},"naics_codes":["541715"],"award":null,"attachments":[],"awards":[],"related":[]}