The Section on Medicinal Chemistry (SMC) develops new molecular entities with implications in improving health and treatment for various metabolic and alcohol associated diseases. To assess the translational potential of novel molecular entities, which would allow us to make decisions to proceed the compounds for further development we utilize multiple derisking assays. These assays comprise of both cell-based (in vitro) testing and then eventually in mice to assess pharmacokinetic parameters to see if the drug is orally available.
\n\n\n\nRequest to procure Chemical Reagent (Assay) Development & Laboratory Testing Service SMC to produce grouped ADME assays and perform a Pharmacokinetic study in C57BL6 mice. By including the Caco-2 Permeability Assay in our ADME evaluation it'll accurately predict the oral absorption potential of our compounds. This well-established in vitro model closely mimics the human intestinal epithelium, providing critical insights into a compound’s passive diffusion, active transport, and efflux processes, such as those mediated by P-glycoprotein (P-gp). The data generated from this assay are vital for informing structure-activity relationship (SAR) optimization, improving compound permeability, and reducing transporter-related liabilities that could hinder bioavailability
","text":"The Section on Medicinal Chemistry (SMC) develops new molecular entities with implications in improving health and treatment for various metabolic and alcohol associated diseases. To assess the translational potential of novel molecular entities, which would allow us to make decisions to proceed the compounds for further development we utilize multiple derisking assays. These assays comprise of both cell-based (in vitro) testing and then eventually in mice to assess pharmacokinetic parameters to see if the drug is orally available.\n\nRequest to procure Chemical Reagent (Assay) Development & Laboratory Testing Service SMC to produce grouped ADME assays and perform a Pharmacokinetic study in C57BL6 mice. By including the Caco-2 Permeability Assay in our ADME evaluation it'll accurately predict the oral absorption potential of our compounds. This well-established in vitro model closely mimics the human intestinal epithelium, providing critical insights into a compound’s passive diffusion, active transport, and efflux processes, such as those mediated by P-glycoprotein (P-gp). The data generated from this assay are vital for informing structure-activity relationship (SAR) optimization, improving compound permeability, and reducing transporter-related liabilities that could hinder bioavailability","origin":"detail"},"notice_type":{"code":"k","label":"Combined Synopsis/Solicitation"},"schema_version":1,"solicitation_number":"75N98026Q01193ENAMINEUSINCPCANIAAA08396","place_of_performance":{"zip":"20892","city":{"code":"7125","name":"Bethesda"},"state":{"code":"MD","name":"Maryland"},"country":{"code":"USA","name":"UNITED STATES"}},"product_service_code":"6505"}],"due_at":"2026-09-19T13:00:00Z","due_date":"2026-09-19","closes_at":"2026-09-19T13:00:00Z","awardable":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N980","office_name":"NATIONAL INSTITUTES OF HEALTH OLAO","state":"MD","country":"USA","winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T07:31:38.954589Z","principal_notice_id":"cda237d603a841e58a64dfcb661f51e2","description":{"text":"The Section on Medicinal Chemistry (SMC) develops new molecular entities with implications in improving health and treatment for various metabolic and alcohol associated diseases. To assess the translational potential of novel molecular entities, which would allow us to make decisions to proceed the compounds for further development we utilize multiple derisking assays. These assays comprise of both cell-based (in vitro) testing and then eventually in mice to assess pharmacokinetic parameters to see if the drug is orally available.\n\nRequest to procure Chemical Reagent (Assay) Development & Laboratory Testing Service SMC to produce grouped ADME assays and perform a Pharmacokinetic study in C57BL6 mice. By including the Caco-2 Permeability Assay in our ADME evaluation it'll accurately predict the oral absorption potential of our compounds. This well-established in vitro model closely mimics the human intestinal epithelium, providing critical insights into a compound’s passive diffusion, active transport, and efflux processes, such as those mediated by P-glycoprotein (P-gp). The data generated from this assay are vital for informing structure-activity relationship (SAR) optimization, improving compound permeability, and reducing transporter-related liabilities that could hinder bioavailability","html":"The Section on Medicinal Chemistry (SMC) develops new molecular entities with implications in improving health and treatment for various metabolic and alcohol associated diseases. To assess the translational potential of novel molecular entities, which would allow us to make decisions to proceed the compounds for further development we utilize multiple derisking assays. These assays comprise of both cell-based (in vitro) testing and then eventually in mice to assess pharmacokinetic parameters to see if the drug is orally available.
\n\n\n\nRequest to procure Chemical Reagent (Assay) Development & Laboratory Testing Service SMC to produce grouped ADME assays and perform a Pharmacokinetic study in C57BL6 mice. By including the Caco-2 Permeability Assay in our ADME evaluation it'll accurately predict the oral absorption potential of our compounds. This well-established in vitro model closely mimics the human intestinal epithelium, providing critical insights into a compound’s passive diffusion, active transport, and efflux processes, such as those mediated by P-glycoprotein (P-gp). The data generated from this assay are vital for informing structure-activity relationship (SAR) optimization, improving compound permeability, and reducing transporter-related liabilities that could hinder bioavailability
","origin":"detail"},"contacts":[{"name":"Vishnuvajjala Hanumanth Rao","role":"primary","email":"vishnuh@mail.nih.gov"}],"place_of_performance":{"zip":"20892","city":{"code":"7125","name":"Bethesda"},"state":{"code":"MD","name":"Maryland"},"country":{"code":"USA","name":"UNITED STATES"}},"office_address":{"zip":"20892","city":"BETHESDA","state":"MD","country":"USA"},"naics_codes":["424690"],"award":null,"attachments":[{"resource_id":"cf16624dfff34dd39c62073f53acd42d","name":"SOW ENAMINE US INC.pdf","kind":"file","mime_type":".pdf","size_bytes":260109,"posted_at":"2026-09-10T21:55:41.380Z","export_controlled":false,"sha256":null,"url":"https://sam.gov/api/prod/opps/v3/opportunities/resources/files/cf16624dfff34dd39c62073f53acd42d/download","mirrored":false}],"awards":[],"related":[{"key":"75N98026Q01163","latest_notice_id":"9c4c22c20e314b619df1326dc703de09","title":"Acquisition of Confocal Microscope Laser System Re","solicitation_number":"75N98026Q01163","notice_type":"k","first_type":"k","first_posted":"2026-09-09","last_posted":"2026-09-09","notices":1,"due_at":"2026-09-16T18:00:00Z","due_date":"2026-09-16","closes_at":"2026-09-16T18:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N980","office_name":"NATIONAL INSTITUTES OF HEALTH OLAO","naics":"334516","psc":"6640","set_aside":null,"state":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T07:31:38.954589Z"},{"key":"75N98026Q01177","latest_notice_id":"a690f9b48b5d4d9181de5c80ede20212","title":"Cryo-Electron Microscopy (Cryo-EM) Services","solicitation_number":"75N98026Q01177","notice_type":"k","first_type":"k","first_posted":"2026-09-09","last_posted":"2026-09-09","notices":1,"due_at":"2026-09-16T18:00:00Z","due_date":"2026-09-16","closes_at":"2026-09-16T18:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N980","office_name":"NATIONAL INSTITUTES OF HEALTH OLAO","naics":"541714","psc":"Q301","set_aside":null,"state":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T07:31:38.954589Z"},{"key":"75N98026Q01159","latest_notice_id":"58e944d42bc24a8a828ea68f822987aa","title":"Nikon ORCA-Quest 2 camera","solicitation_number":"75N98026Q01159","notice_type":"k","first_type":"k","first_posted":"2026-09-09","last_posted":"2026-09-09","notices":1,"due_at":"2026-09-16T18:00:00Z","due_date":"2026-09-16","closes_at":"2026-09-16T18:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N980","office_name":"NATIONAL INSTITUTES OF HEALTH OLAO","naics":"334516","psc":"6640","set_aside":null,"state":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T07:31:38.954589Z"},{"key":"75N98026Q0115104750","latest_notice_id":"45b89d513b3f470b991e9d3d038910e4","title":"Upgrade for LUMICKS C-trap to 3 color confocal instrument","solicitation_number":"75N98026Q01151-04750","notice_type":"k","first_type":"k","first_posted":"2026-09-05","last_posted":"2026-09-10","notices":2,"due_at":"2026-09-16T19:00:00Z","due_date":"2026-09-16","closes_at":"2026-09-16T19:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N980","office_name":"NATIONAL INSTITUTES OF HEALTH OLAO","naics":"811210","psc":"J066","set_aside":null,"state":"NC","country":"USA","winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T07:31:38.954589Z"},{"key":"75N98026Q01207","latest_notice_id":"00b90065c7454f2ebcc55d01e377637a","title":"Specialized Clinical Laboratory Testing Services","solicitation_number":"75N98026Q01207","notice_type":"p","first_type":"p","first_posted":"2026-09-12","last_posted":"2026-09-12","notices":1,"due_at":"2026-09-17T13:00:00Z","due_date":"2026-09-17","closes_at":"2026-09-17T13:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N980","office_name":"NATIONAL INSTITUTES OF HEALTH OLAO","naics":"541380","psc":"Q301","set_aside":null,"state":"MD","country":"USA","winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T07:31:38.954589Z"}]}