# Renewal of licensing fee for the transgenic mouse strain, B-hIL2RA

Canonical: https://abierto.us/opportunities/75n98026q00467

- Solicitation number: 75N98026Q00467
- Notice type: Presolicitation
- Status: Closed. Deadline was June 8, 2026 at 9:00 AM EDT
- Department: Department of Health and Human Services
- Agency: National Institutes of Health
- Contracting office: National Institutes of Health Olao (75N980)
- NAICS: 51321 Software Publishers
- Product or service code: 7A21 Business Application off-the-shelf software delivered by perpetual license, which also encompasses enterprise level software enabling mission capability and business operational support.
- Place of performance: Maryland
- County: Montgomery County (FIPS 24031). https://abierto.us/counties/montgomery-county-md-24031
- First posted: May 28, 2026
- Last posted: May 28, 2026
- SAM.gov: https://sam.gov/workspace/contract/opp/d5d41b4868e442a8b06dd1fd4a373f8c/view

## Description

The MIB is conducting pre-clinical research on photoimmunotherapy (PIT), a targeted treatment approach that uses light activation to destroy specific cells. One area of this research focuses on IL2RA, a protein expressed on regulatory T cells (Tregs). These cells can reduce the immune system’s ability to respond effectively to cancer. The objective of this work is to selectively eliminate IL2RA-expressing Tregs in order to improve anti-cancer immune responses.

To support this research, MIB uses a transgenic mouse strain known as B-hIL2RA, which expresses the human form of IL2RA rather than the mouse form. Use of this model is essential because it enables evaluation of the same treatment materials, including antibodies, that are intended for future human application. As a result, this mouse strain has proven invaluable in the MIB’s ongoing research program. The MIB is requesting to renew a licensing fee for transgenic mice, B-hIL2RA. B-hIL2RA transgenic mice.

## Publications

- May 28, 2026: Presolicitation, due June 8, 2026 at 9:00 AM EDT. Notice d5d41b4868e442a8b06dd1fd4a373f8c. https://sam.gov/workspace/contract/opp/d5d41b4868e442a8b06dd1fd4a373f8c/view

## Points of contact

- John Burton, burtonjo@mail.nih.gov

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/75n98026q00467.