# Synthesis of HNMT, NNMT intermediates and PK

Canonical: https://abierto.us/opportunities/75n95025q00236

- Solicitation number: 75N95025Q00236
- Notice type: Presolicitation
- Status: Awarded to Chemogenics Biopharma, LLC
- Department: Department of Health and Human Services
- Agency: National Institutes of Health
- Contracting office: National Institutes of Health Nida (75N950)
- NAICS: 541380 Testing Laboratories and Services
- Product or service code: B504 Chemical/Biological Studies and Analysis
- Place of performance: Rockville, Maryland
- County: Montgomery County (FIPS 24031). https://abierto.us/counties/montgomery-county-md-24031
- City: Rockville. https://abierto.us/cities/rockville-md-2467675
- First posted: August 12, 2025
- Last posted: August 12, 2025
- SAM.gov: https://sam.gov/workspace/contract/opp/f9c832b0ff84446bb9bb46dfb5f13a01/view

## Description

NCATS is in need of custom synthesis and bioanalytical services in internal projects focused on developing small molecule inhibitors of physiological small molecule methyltransferases. NACTS is pursuing small molecules in two projects where methyltransferases are implicated in disease. NCATS requires key intermediates that will allow for the lab to scale up lead compounds or make analogs. NCATS also requires exposure data in various tissues of interest to gauge compound concentrations to select compounds for POC.

100g of N-(pyridin-3-yl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-e][1,4]diazepin-8-amine 100g of (tert-butyl (R)-3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3- yl)piperidine-1- carboxylate. Mouse PK on at least 10 compounds with routes and tissues determined. The final purity has to be >95% with optical purity >98%. Spectroscopic characterization and analytical data will be required and verified.

## Award on USAspending

- Recipient: Chemogenics Biopharma, LLC (UEI MQLWQEJKQLR3)
- Contract: 75N95025P00412, purchase order
- Obligated: $101,000.00
- Competition: Not Competed Under SAP, 1 offers received
- Link: solicitation number 75N95025Q00236 equals the FPDS solicitation identifier; same awarding office 75N950 (high confidence)
- Record: https://www.usaspending.gov/award/CONT_AWD_75N95025P00412_7529_-NONE-_-NONE-/


## Publications

- August 12, 2025: Presolicitation, due August 19, 2025 at 12:00 PM EDT. Notice f9c832b0ff84446bb9bb46dfb5f13a01. https://sam.gov/workspace/contract/opp/f9c832b0ff84446bb9bb46dfb5f13a01/view

## Points of contact

- Andrew Varley, andrew.varley@nih.gov, 3018275851
- Joshua T. Lazarus, Josh.Lazarus@nih.gov, 3018276923

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Source: SAM.gov Contract Opportunities bulk extract and USAspending.gov award data. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/75n95025q00236.