# Transcriptomics Sequencing and analysis in Liver Spheroids

Canonical: https://abierto.us/opportunities/75n95025q00040

- Solicitation number: 75N95025Q00040
- Notice type: Combined synopsis and solicitation
- Status: Closed. Deadline was November 22, 2024 at 3:00 PM EST
- Department: Department of Health and Human Services
- Agency: National Institutes of Health
- Contracting office: National Institutes of Health Nida (75N950)
- NAICS: 325414 Biological Product (except Diagnostic) Manufacturing
- Product or service code: Q301 Reference Laboratory Testing
- Place of performance: Rockville, Maryland
- County: Montgomery County (FIPS 24031). https://abierto.us/counties/montgomery-county-md-24031
- City: Rockville. https://abierto.us/cities/rockville-md-2467675
- First posted: November 15, 2024
- Last posted: November 15, 2024
- SAM.gov: https://sam.gov/workspace/contract/opp/744ddc5e79274223ad51517e767ff410/view

## Description

The National Center for Advancing Translational Sciences (NCATS) requires transcriptomics sequencing and analysis in liver spheroids. This requisition is requesting a contract to evaluate the RNA expression in liver toxicity associated with the systemic administration of antisense oligonucleotides (ASOs) in previously tested human, rat and mouse animal models. The project's phase one goal is to develop a predictive model of candidate ASO therapies' safety and acute toxicity.

NCATS is seeking technical support to evaluate the safety and acute liver toxicity of candidate ASOs by checking the gene expression. The results from these studies, in conjunction with existing cell-based assays, will help better predict the safety of future candidate ASOs intended for clinical use. The objective of this contract is to generate proof-of-concept data for evaluating the ability of the 3D liver microtissue platform to predict the hepatoxicity of individual ASOs.

If successful, this will represent a new means to screen ASOs for this type of toxicity that is cheaper, faster, and has high throughput. NCATS is seeking technical support to evaluate the safety and acute liver toxicity of candidate ASOs by checking the gene expression. The results from these studies, in conjunction with existing cell-based assays, will help better predict the safety of future candidate ASOs intended for clinical use.

## Publications

- November 15, 2024: Combined synopsis and solicitation, due November 22, 2024 at 3:00 PM EST. Notice 744ddc5e79274223ad51517e767ff410. https://sam.gov/workspace/contract/opp/744ddc5e79274223ad51517e767ff410/view

## Points of contact

- Chandani Hangilipola, chandani.hangilipola@nih.gov, 13014807089

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/75n95025q00040.