{"canonical":"https://abierto.us/opportunities/75n95025q00040","key":"75N95025Q00040","url":"https://abierto.us/opportunities/75n95025q00040","title":"Transcriptomics Sequencing and analysis in Liver Spheroids","solicitation_number":"75N95025Q00040","notice_type":"k","open":false,"response_deadline":"2024-11-22T20:00:00Z","first_posted":"2024-11-15","last_posted":"2024-11-15","department":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","subagency":"NATIONAL INSTITUTES OF HEALTH","office":"NATIONAL INSTITUTES OF HEALTH NIDA","naics":"325414","psc":"Q301","set_aside":null,"place_state":"MD","place_county":"24031","place_county_name":"Montgomery County","place_city":"2467675","place_city_name":"Rockville","winner":null,"award_amount":null,"publications":[{"notice_id":"744ddc5e79274223ad51517e767ff410","title":"Transcriptomics Sequencing and analysis in Liver Spheroids","solicitation_number":"75N95025Q00040","notice_type":"k","base_type":"k","posted":"2024-11-15","posted_at":null,"due_at":"2024-11-22T20:00:00Z","due_date":"2024-11-22","cancelled":null,"archived":null,"archive_date":"2024-11-23","award_number":null,"awardee_name":null,"amount":null,"link_sam":"https://sam.gov/workspace/contract/opp/744ddc5e79274223ad51517e767ff410/view","enriched":false,"history":[]}],"latest_notice_id":"744ddc5e79274223ad51517e767ff410","first_type":"k","notices":[{"dates":{"posted":"2024-11-15","response_deadline":{"raw":"2024-11-22T15:00:00-05:00","utc":"2024-11-22T20:00:00Z","date":"2024-11-22","time":"15:00:00","utc_offset_seconds":-18000}},"links":{"sam":"https://sam.gov/workspace/contract/opp/744ddc5e79274223ad51517e767ff410/view"},"naics":{"codes":["325414"],"primary":"325414"},"title":"Transcriptomics Sequencing and analysis in Liver Spheroids","agency":{"office":{"code":"75N950","name":"NATIONAL INSTITUTES OF HEALTH NIDA"},"subtier":{"code":"7529","name":"NATIONAL INSTITUTES OF HEALTH"},"department":{"code":"075","name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF"},"office_address":{"zip":"20892","city":"Bethesda","state":"MD","country":"USA"},"organization_type":"OFFICE"},"status":{"active":false,"archive_date":"2024-11-23","archive_type":"auto_custom"},"contacts":[{"name":"Chandani Hangilipola","role":"primary","email":"chandani.hangilipola@nih.gov","phone":"13014807089"}],"base_type":{"code":"k","label":"Combined Synopsis/Solicitation"},"notice_id":"744ddc5e79274223ad51517e767ff410","provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/Archived%20Data/FY2025_archived_opportunities.csv","etag":"\"d47226e3d2c6545974b252e103f82b34-139\"","fetched_at":"2026-09-16T19:12:38.374141Z","row_sha256":"2afc6527215e04aa0e7343477f67b0613597270c25db4becf4013313e53aa84b","last_modified":"2026-09-13T14:49:20Z"},"updated_at":"2026-09-16T19:12:38.374141Z","first_seen_at":"2026-09-16T19:12:38.374141Z"},"description":{"text":"The National Center for Advancing Translational Sciences (NCATS) requires transcriptomics sequencing and analysis in liver spheroids. This requisition is requesting a contract to evaluate the RNA expression in liver toxicity associated with the systemic administration of antisense oligonucleotides (ASOs) in previously tested human, rat and mouse animal models. The project's phase one goal is to develop a predictive model of candidate ASO therapies' safety and acute toxicity. NCATS is seeking technical support to evaluate the safety and acute liver toxicity of candidate ASOs by checking the gene expression. The results from these studies, in conjunction with existing cell-based assays, will help better predict the safety of future candidate ASOs intended for clinical use. The objective of this contract is to generate proof-of-concept data for evaluating the ability of the 3D liver microtissue platform to predict the hepatoxicity of individual ASOs. If successful, this will represent a new means to screen ASOs for this type of toxicity that is cheaper, faster, and has high throughput. NCATS is seeking technical support to evaluate the safety and acute liver toxicity of candidate ASOs by checking the gene expression. The results from these studies, in conjunction with existing cell-based assays, will help better predict the safety of future candidate ASOs intended for clinical use.","origin":"extract"},"notice_type":{"code":"k","label":"Combined Synopsis/Solicitation"},"schema_version":1,"solicitation_number":"75N95025Q00040","place_of_performance":{"zip":"20850","city":{"name":"Rockville"},"state":{"code":"MD"},"country":{"code":"USA"}},"product_service_code":"Q301"}],"due_at":"2024-11-22T20:00:00Z","due_date":"2024-11-22","closes_at":"2024-11-22T20:00:00Z","awardable":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N950","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","state":"MD","county":"24031","county_name":"Montgomery County","city":"2467675","city_name":"Rockville","country":"USA","winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z","principal_notice_id":"744ddc5e79274223ad51517e767ff410","description":{"text":"The National Center for Advancing Translational Sciences (NCATS) requires transcriptomics sequencing and analysis in liver spheroids. This requisition is requesting a contract to evaluate the RNA expression in liver toxicity associated with the systemic administration of antisense oligonucleotides (ASOs) in previously tested human, rat and mouse animal models. The project's phase one goal is to develop a predictive model of candidate ASO therapies' safety and acute toxicity. NCATS is seeking technical support to evaluate the safety and acute liver toxicity of candidate ASOs by checking the gene expression. The results from these studies, in conjunction with existing cell-based assays, will help better predict the safety of future candidate ASOs intended for clinical use. The objective of this contract is to generate proof-of-concept data for evaluating the ability of the 3D liver microtissue platform to predict the hepatoxicity of individual ASOs. If successful, this will represent a new means to screen ASOs for this type of toxicity that is cheaper, faster, and has high throughput. NCATS is seeking technical support to evaluate the safety and acute liver toxicity of candidate ASOs by checking the gene expression. The results from these studies, in conjunction with existing cell-based assays, will help better predict the safety of future candidate ASOs intended for clinical use.","html":null,"origin":"extract"},"contacts":[{"name":"Chandani Hangilipola","role":"primary","email":"chandani.hangilipola@nih.gov","phone":"13014807089"}],"place_of_performance":{"zip":"20850","city":{"name":"Rockville"},"state":{"code":"MD"},"country":{"code":"USA"}},"office_address":{"zip":"20892","city":"Bethesda","state":"MD","country":"USA"},"naics_codes":["325414"],"award":null,"attachments":[],"awards":[],"related":[{"key":"75N98026Q01128","latest_notice_id":"bb06bb3df12b41368577717da748025d","title":"Account Management, Planning, and Maintenance for Online Crowd-Sourced Surveys and Cognitive Tasks for Individuals","solicitation_number":"75N98026Q01128","notice_type":"k","first_type":"r","first_posted":"2026-09-01","last_posted":"2026-09-16","notices":2,"due_at":"2026-09-21T13:00:00Z","due_date":"2026-09-21","closes_at":"2026-09-21T13:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N950","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","naics":"541990","psc":"R499","set_aside":null,"state":"MD","county":"24031","county_name":"Montgomery County","city":"2407125","city_name":"Bethesda","country":"USA","winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-17T06:28:38.602097Z"},{"key":"75N98026R00157SB","latest_notice_id":"ee510f1cce674a259b707473c3e23234","title":"CTN Data, Statistics, and Clinical Trial Support Center (DSC7)","solicitation_number":"75N98026R00157SB","notice_type":"r","first_type":"r","first_posted":"2026-09-09","last_posted":"2026-09-09","notices":1,"due_at":"2026-09-30T17:00:00Z","due_date":"2026-09-30","closes_at":"2026-09-30T17:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N950","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","naics":"541715","psc":"AN11","set_aside":"SBA","state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z"},{"key":"75N98026R00157OT","latest_notice_id":"a367c8ec486d4b1fa7709ac1c2c6e019","title":"CTN Data, Statistics, and Clinical Trial Support Center (DSC7)","solicitation_number":"75N98026R00157OT","notice_type":"r","first_type":"r","first_posted":"2026-09-09","last_posted":"2026-09-09","notices":1,"due_at":"2026-09-30T17:00:00Z","due_date":"2026-09-30","closes_at":"2026-09-30T17:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N950","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","naics":"541715","psc":"AN11","set_aside":null,"state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z"},{"key":"75N95026R00003","latest_notice_id":"180e97fe5cab4693b99f561c5ede9778","title":"Data Access Program","solicitation_number":"75N95026R00003","notice_type":"p","first_type":"p","first_posted":"2025-12-15","last_posted":"2025-12-15","notices":2,"due_at":"2026-12-30T18:00:00Z","due_date":"2026-12-30","closes_at":"2026-12-30T18:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N950","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","naics":"541611","psc":"R499","set_aside":null,"state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z"}]}