{"canonical":"https://abierto.us/opportunities/75n95024r00062","key":"75N95024R00062","url":"https://abierto.us/opportunities/75n95024r00062","title":"NINDS Division Translational Research – Rodent Pharmacokinetic (PK) Studies","solicitation_number":"75N95024R00062","notice_type":"a","open":false,"response_deadline":"2024-07-29T15:00:00Z","first_posted":"2024-03-11","last_posted":"2024-09-09","department":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","subagency":"NATIONAL INSTITUTES OF HEALTH","office":"NATIONAL INSTITUTES OF HEALTH NIDA","naics":"541380","psc":"Q301","set_aside":null,"place_state":"MD","place_county":"24031","place_county_name":"Montgomery County","place_city":"2407125","place_city_name":"Bethesda","winner":"BLACKROCK MICROSYSTEMS, INC","award_amount":"129586.25","publications":[{"notice_id":"b6722b66e96d4fb48d486018cc8a84b2","title":"Request for Information (RFI) - NINDS Division Translational Research – Continuous Rodent and Non-Rodent Pharmacokinetic (PK) Assessments","solicitation_number":"75N95024R00062","notice_type":"s","base_type":"s","posted":"2024-03-11","posted_at":null,"due_at":"2024-04-15T15:00:00Z","due_date":"2024-04-15","cancelled":null,"archived":null,"archive_date":"2024-04-30","award_number":null,"awardee_name":null,"amount":null,"link_sam":"https://sam.gov/workspace/contract/opp/b6722b66e96d4fb48d486018cc8a84b2/view","enriched":false,"history":[]},{"notice_id":"e24d97b1fc3749eaa369ec73fcf0e58e","title":"NINDS Division Translational Research – Rodent Pharmacokinetic (PK) Studies","solicitation_number":"75N95024R00062","notice_type":"r","base_type":"s","posted":"2024-06-20","posted_at":null,"due_at":"2024-07-01T15:00:00Z","due_date":"2024-07-01","cancelled":null,"archived":null,"archive_date":"2024-07-16","award_number":null,"awardee_name":null,"amount":null,"link_sam":"https://sam.gov/workspace/contract/opp/e24d97b1fc3749eaa369ec73fcf0e58e/view","enriched":false,"history":[]},{"notice_id":"ec997e8bd789425b98ef5cfcfa96930b","title":"NINDS Division Translational Research – Rodent Pharmacokinetic (PK) Studies","solicitation_number":"75N95024R00062","notice_type":"k","base_type":"r","posted":"2024-07-17","posted_at":null,"due_at":"2024-07-29T15:00:00Z","due_date":"2024-07-29","cancelled":null,"archived":null,"archive_date":"2024-08-13","award_number":null,"awardee_name":null,"amount":null,"link_sam":"https://sam.gov/workspace/contract/opp/ec997e8bd789425b98ef5cfcfa96930b/view","enriched":false,"history":[]},{"notice_id":"7bbad31262064ff28f97b606ca4a05a4","title":"NINDS Division Translational Research – Rodent Pharmacokinetic (PK) Studies","solicitation_number":"75N95024R00062","notice_type":"k","base_type":"k","posted":"2024-07-24","posted_at":null,"due_at":"2024-07-29T15:00:00Z","due_date":"2024-07-29","cancelled":null,"archived":null,"archive_date":"2024-08-13","award_number":null,"awardee_name":null,"amount":null,"link_sam":"https://sam.gov/workspace/contract/opp/7bbad31262064ff28f97b606ca4a05a4/view","enriched":false,"history":[]},{"notice_id":"d96fd03e72a1455bbad729f7876461ba","title":"NINDS Division Translational Research – Rodent Pharmacokinetic (PK) Studies","solicitation_number":"75N95024R00062","notice_type":"a","base_type":"k","posted":"2024-09-09","posted_at":null,"due_at":null,"due_date":null,"cancelled":null,"archived":null,"archive_date":"2024-09-26","award_number":"75N95024P00495","awardee_name":"MELIOR DISCOVERY INC Exton","amount":"129586.25","link_sam":"https://sam.gov/workspace/contract/opp/d96fd03e72a1455bbad729f7876461ba/view","enriched":false,"history":[]}],"latest_notice_id":"d96fd03e72a1455bbad729f7876461ba","first_type":"s","notices":[{"dates":{"posted":"2024-03-11","response_deadline":{"raw":"2024-04-15T11:00:00-04:00","utc":"2024-04-15T15:00:00Z","date":"2024-04-15","time":"11:00:00","utc_offset_seconds":-14400}},"links":{"sam":"https://sam.gov/workspace/contract/opp/b6722b66e96d4fb48d486018cc8a84b2/view"},"naics":{"codes":["541380"],"primary":"541380"},"title":"Request for Information (RFI) - NINDS Division Translational Research – Continuous Rodent and Non-Rodent Pharmacokinetic (PK) Assessments","agency":{"office":{"code":"75N950","name":"NATIONAL INSTITUTES OF HEALTH NIDA"},"subtier":{"code":"7529","name":"NATIONAL INSTITUTES OF HEALTH"},"department":{"code":"075","name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF"},"office_address":{"zip":"20892","city":"Bethesda","state":"MD","country":"USA"},"organization_type":"OFFICE"},"status":{"active":false,"archive_date":"2024-04-30","archive_type":"auto15"},"contacts":[{"name":"Sneha Singh","role":"primary","email":"sneha.singh@nih.gov"}],"base_type":{"code":"s","label":"Special Notice"},"notice_id":"b6722b66e96d4fb48d486018cc8a84b2","provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/Archived%20Data/FY2024_archived_opportunities.csv","etag":"\"d582488fe153a9f11bf629913d176ffc-137\"","fetched_at":"2026-09-16T19:07:39.720164Z","row_sha256":"82c355e0558178bfde5e4942c08944d5f29b9532578c5caa95916469fb2c4577","last_modified":"2026-09-13T14:47:40Z"},"updated_at":"2026-09-16T19:07:39.720164Z","first_seen_at":"2026-09-16T19:07:39.720164Z"},"description":{"text":"See Attached PDF. REQUEST FOR INFORMATION Solicitation Number: 75N95024R00062 Title: NINDS Division Translational Research – Continuous Rodent and Non-Rodent Pharmacokinetic (PK) Assessments Classification Code: Q301 Medical – Laboratory Testing NAICS Code: 541380 Testing Laboratories and Services Size Standard: $19M Description: This is a Request for Information (RFI). This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this RFI is to obtain knowledge and information for programs planning purposes. The Government is also considering NAICS 325414 Biological Product (except Diagnostic) Manufacturing, Size Standard 1,250 employees. Background: The National Institute of Neurological Disorders and Stroke (NINDS) and the NIH Blueprint Neurotherapeutics Network (BPN) (http://neuroscienceblueprint.nih.gov/bpdrugs/index.htm) have established a ‘virtual pharma' network of contract service providers and consultants with extensive industry experience to enable therapeutic (e.g., small molecule, peptide, biologic) development in the NIH research community. This network has a need to run routine pharmacokinetic studies in support of the program. Studies are mostly iv/po rodent studies but information on capabilities to run other routes of administration and other species is also of interest. Purpose and Objectives: The NINDS is interested in identifying commercial sources with capabilities and qualifications that could run routine rodents pharmacokinetic (PK) testing for the purposes of new therapeutics developments. Additionally, information capabilities to run dog PK and other routes of administration is also sought. Requirements: (See Attached PDF ) Please describe your organization’s ability to perform the following tasks and answer the following questions: Is your organization a small business as defined by the SBA? What are your general capabilities to provide commercial pharmacokinetic (PK) studies to support drug discovery? What species do you typically offer to your commercial customers e.g. mouse/rat/dog/primate etc? What routes besides IV and oral can you provide (e.g. IT, ocular etc)? Where would the work be performed? For each of study types below please answer the following: State your organization ability and track record offering these types of studies as a commercial option to the scientific community? Do your organization’s standard designs differ? What are the usual timelines for individual study completion, from study request, assuming compound is available for immediate shipment, to study initiation and delivery of interim and final reports? What is your organization’s ability to run multiple studies in parallel? What is the approximate expected cost of the proposed studies at your organization (note #1, 3, 4 and 5 cost with and without brain level determination is desired)? Sample Designs for Consideration: Rat Pharmacokinetic with or without brain level determination A design for a rat PK study is presented below. It is anticipated that a similar study design will be used for the majority of studies to be completed. Group Test Compound Dose (mmol/kg) Route # of Animals Plasma Collection (hr) Brain Collection (hr) 1 A TBD IV 3 0,.083,.25,.5,1,2,4,8,12,24 - 2 A TBD PO 3 0,.25,.5,1,2,4,8,12,24 - 3 A TBD IV 3 1 1 3 male rodents per group, 1 PO and 2IV groups. Blood (plasma) collected via jugular catheters Assume that a bioanalytic method is unavailable and must be developed for each study. Study results are intended to support chemistry optimization, thus rapid turnaround is essential to meet the needs of the iterative drug design cycle. Reports should include: A detailed rat PK study protocol based on the design used and data report including graphical representation of the data and separate data table. Rodent Brain Pharmacokinetics Analysis The contractor shall administer BPN-supplied compounds to rodents (rat or mouse) and assess blood and brain levels of at various time points. A design for a rat brain PK study is presented below, as a starting point for protocol development, subject to modification. It is anticipated that a similar study design will be used for the majority of studies to be completed, but minor modifications may be needed based on the requirements of each project. Group Test Compound Dose (mmol/kg) Route # of Animals Plasma Collection (hr) Brain Collection (hr) 1 A TBD IV or oral 3 0.5 0.5 2 A TBD IV or oral 3 1 1 3 A TBD IV or oral 3 2 2 4 A TBD IV or oral 3 6 6 5 A TBD IV or oral 3 12 12 6 A TBD IV or oral 3 24 24 3 male rats per time point, 6 time points. Blood (plasma) and brain collections at 0.5,1,2,6, and 12 h, 24h post administration. Assume that a bioanalytic methods are available from prior study. Study results are intended to support chemistry optimization, thus rapid turnaround is essential to meet the needs of the iterative drug design cycle. Reports should include: A detailed rat PK study protocol based on the design used and data report including graphical representation of the data and separate data table. Rodent Plasma Sample Pharmacokinetic Analysis The contractor shall analyze rodent plasma and brain samples supplied by the NIH to measure levels of the compound being studied to support pharmacokinetic assessment of samples collected off-site, as a component of in vivo activity studies in rodent models of disease. It is anticipated that samples will be obtained at 6 time points, from 3 animals per time point, for a total of 36 samples. Assume that a bioanalytic method is unavailable and must be developed for each study. Study results are intended to support chemistry optimization, thus rapid turnaround is essential to meet the needs of the iterative drug design cycle. Mouse Pharmacokinetic with or without brain level determination Group Test Compound Dose Route Dose (mg/kg) Sub-group No. of Animals Blood (Plasma) Collection Timepoint (hr) Brain Collection Timepoint (hr) 1 A IV 1 A 3 0.083, 1 1 B 3 0.25, 4 4 C 3 0.5, 8 8 D 3 2, 24 24 2 A PO 5 A 3 1 1 B 3 0.25, 4 4 C 3 0.5, 8 8 D 3 2, 24 24 Assume that a bioanalytic method is unavailable and must be developed for each study. Study results are intended to support chemistry optimization, thus rapid turnaround is essential to meet the needs of the iterative drug design cycle. Dog Pharmacokinetic determination Group Test Article Dose Route Dose Level (mg/kg) Dose Conc. (mg/ml) Dosing Volume (ml/kg) No. of Animals Blood & Plasma Collection Time Point (hr) 1 A iv 1 0.2 5 3 Pre-dose, 0.083, 0.25, 0.5, 1, 2, 4, 8, 12, 24, 48 2 A po 5 1 5 3 Pre-dose, 0.25, 0.5, 1, 2, 4, 8, 12, 24, 48 Species and Strain: Beagle dog Assume that a bioanalytic method is unavailable for dog and must be developed for each study, but mouse and/or rat bioanalytical will available. Study results are intended to support chemistry optimization, thus rapid turnaround is essential to meet the needs of the iterative drug design cycle. Other Important Considerations: In case domestic sources are available and capable of fulfilling the Government’s need, and a future solicitation is published, the Government will use evaluation preferences in accordance with FAR 25. NIH has policies, regulations, and guidance that protect animals used in research, training, and testing. Offerors must meet regulatory compliances and safety requirements. Please describe how your organization complies with these requirements. Information Sought: One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2” x 11” paper size, with 1” top, bottom, left and right margins, and with single or double spacing. The information submitted must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to twenty (20) page limit. The 20-page limit does not include the cover page, executive summary, or references, if requested. All responses to this notice must be submitted electronically to the Contract Specialist. Facsimile responses are NOT accepted. The response must be submitted to Sneha Singh, Contract Specialist, at e-mail address sneha.singh@nih.gov The response must be received on or before April 15, 2024, at 11:00 a.m., Eastern Time. Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed. Information provided will be used to assess tradeoffs and alternatives available for the potential requirement and may lead to the development of a solicitation. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. Any solicitation resulting from the analysis of information obtained will be announced to the public in www.sam.gov in accordance with the FAR Part 5. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).","origin":"extract"},"notice_type":{"code":"s","label":"Special Notice"},"schema_version":1,"solicitation_number":"75N95024R00062","place_of_performance":{"city":{"name":"Bethesda"},"state":{"code":"MD"},"country":{"code":"USA"}}},{"dates":{"posted":"2024-06-20","response_deadline":{"raw":"2024-07-01T11:00:00-04:00","utc":"2024-07-01T15:00:00Z","date":"2024-07-01","time":"11:00:00","utc_offset_seconds":-14400}},"links":{"sam":"https://sam.gov/workspace/contract/opp/e24d97b1fc3749eaa369ec73fcf0e58e/view"},"naics":{"codes":["541380"],"primary":"541380"},"title":"NINDS Division Translational Research – Rodent Pharmacokinetic (PK) Studies","agency":{"office":{"code":"75N950","name":"NATIONAL INSTITUTES OF HEALTH NIDA"},"subtier":{"code":"7529","name":"NATIONAL INSTITUTES OF HEALTH"},"department":{"code":"075","name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF"},"office_address":{"zip":"20892","city":"Bethesda","state":"MD","country":"USA"},"organization_type":"OFFICE"},"status":{"active":false,"archive_date":"2024-07-16","archive_type":"auto15"},"contacts":[{"name":"Sneha Singh","role":"primary","email":"sneha.singh@nih.gov"}],"base_type":{"code":"s","label":"Special Notice"},"notice_id":"e24d97b1fc3749eaa369ec73fcf0e58e","provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/Archived%20Data/FY2024_archived_opportunities.csv","etag":"\"d582488fe153a9f11bf629913d176ffc-137\"","fetched_at":"2026-09-16T19:07:39.720164Z","row_sha256":"299ca3131ece01824d953f86d3765bdb7eebce568a119d365ab8014db08a9f1b","last_modified":"2026-09-13T14:47:40Z"},"updated_at":"2026-09-16T19:07:39.720164Z","first_seen_at":"2026-09-16T19:07:39.720164Z"},"description":{"text":"See PDF Attachment below. Sources Sought Notice Solicitation Number: 75N95024R00062 Title: NINDS Division Translational Research – Rodent Pharmacokinetic (PK) Studies Classification Code: Q301 Medical – Laboratory Testing NAICS Code: 541380 Testing Laboratories and Services Size Standard: $19M DESCRIPTION: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. The Government is also considering NAICS 325414 Biological Product (except Diagnostic) Manufacturing, Size Standard 1,250 employees. Background: The National Institutes of Health (NIH) Blueprint Neurotherapeutics Network (BPN) has a series of collaborative drug discovery and development projects focused on supporting preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics to support their eventual use as therapeutics for nervous system disorders. These projects will be developing therapeutic candidates through an iterative process of lead optimization, in vitro and in vivo testing. A component of this process will be the conduct of in vivo pharmacokinetic (PK) assessment of small molecules and biologics (e.g, peptides, etc). The contractor shall conduct rodent PK studies to assess blood and tissue (primarily brain) levels of a novel test article supplied by the PI or the Project Team in order to support lead optimization and preclinical pharmacokinetic efforts under the NIH BPN program. Purpose and Objectives: The National Institute of Neurological Disorders and Stroke (NINDS) requires plasma and brain sample analysis and rodent pharmacokinetic (PK) testing for the purposes of new therapeutics developments. Scope of Work: Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government, as needed to perform the following PK studies under this purchase order: Base Task: Mouse Plasma and brain samples analysis for 2 compounds One mouse pharmacokinetic study One rat pharmacokinetic study Optional Task 1: One rat pharmacokinetic study Optional Task 2: One rat pharmacokinetic study Requirements: The Government will initiate a study with the submission of a study request form which will include available information on the test article to be evaluated. After completion of the in-life portion of the study, the contractor shall estimate Pharmacokinetic parameters of the test articles or samples using WinNonlin (Phoenix software, Pharsight). The Contractor shall prepare an excel file and submit it as a data report for each study requested by the Contracting Officer’s Representative (COR) within 4 weeks or less of receiving of compounds or samples for bioanalysis. Mouse Plasma and Brain Samples Analysis for 2 Compounds The contractor shall conduct studies to analyze plasma and tissue samples supplied by the BPN to measure levels of two test articles being studied to support pharmacokinetic assessment. Each compound has 16 plasma samples and 13 brain samples. Samples will be collected off-site, as a component of in vivo activity studies conducted by the Project Teams. For budget development purposes assume no analytical method exist and a total of 32 plasma samples and 26 brain samples will be analyzed. Rodent Pharmacokinetic Studies The contractor shall conduct pharmacokinetic studies, administering BPN - supplied test articles to rodents (e.g., rat or mouse) and assessing blood concentrations of test article at various time points and calculating standard PK parameters. Designs for a basic mouse or rat PK study is presented below. 2.a Mouse Pharmacokinetic Study Design Group Test Compound Dose Route Subgroup No. of Animals Plasma Collection (hr.) 1 Compound A TBD iv A 3 0.083, 0.5 iv B 3 0.25, 1 iv C 3 2, 4 iv D 3 6, 8 2 Compound A TBD po A 3 0.25, 0.5 po B 3 0.75, 1 po C 3 2, 4 po D 3 6, 8 Blood (plasma) collected via retro orbital sinus stick and/or cardiac puncture last time point (prefer volume of 50-60 ul if possible since C57 mouse is smaller than CD1 mouse or other strains) Dose levels will be determined at the time of protocol development based on available information on the test article. For the purposes of proposal development, assume that C57/BL6 mice will be used and a bioanalytic method is not available. The expected LLOQ is 1ng/mL for plasma (or value applicable to biologic test article). 2.b. Rat Pharmacokinetic Study Group Test Article Dose (mg/kg) Route No. of Animals Plasma Collection 1 Compound B TBD iv 3 10 time points 2 Compound B TBD po 3 10 time points Blood (plasma) collected via jugular catheters. Blood will not be collected from the catheter used to administer the dose formulation. Route of administration will be iv/po. Dose levels will be determined at the time of protocol development based on available information on the test article. Plasma will be collected on after dose administration for 10 time points (e.g., pre-dose, 0.083, 0.25, 0.5,1, 2, 4, 6, 8 and 24). For the purposes of proposal development, assume that a bioanalytic method is not available and must be developed. The expected LLOQ is 1ng/mL for plasma and 5ng/mL for brain. CAPABILITY STATEMENT: Small business concerns that believe they possess the capabilities to provide the required services should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately. Additionally, the capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the requirements outlined, 3) any contractor GSA Schedule contracts and/or other government-wide acquisition contracts (GWACs) by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Small businesses must also provide their Company Name, DUNS number, Physical Address, and Point of Contact Information. Interested small businesses are required to identify their type of business, applicable North American Industry Classification System (NAICS) Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2” x 11” paper size, with 1” top, bottom, left and right margins, and with single or double spacing. The information submitted must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. The response must be submitted electronically to the Contract Specialist, Sneha Singh, at sneha.singh@nih.gov. Facsimile responses are NOT accepted. The response must be received on or before July 1, 2024 at 11:00 A.M., Eastern Time. DISCLAIMER AND IMPORTANT NOTES: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in www.sam.gov. However, responses to this notice will not be considered adequate responses to a solicitation. CONFIDENTIALITY: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).","origin":"extract"},"notice_type":{"code":"r","label":"Sources Sought"},"schema_version":1,"solicitation_number":"75N95024R00062","place_of_performance":{"city":{"name":"Bethesda"},"state":{"code":"MD"},"country":{"code":"USA"}},"product_service_code":"Q301"},{"dates":{"posted":"2024-07-17","response_deadline":{"raw":"2024-07-29T11:00:00-04:00","utc":"2024-07-29T15:00:00Z","date":"2024-07-29","time":"11:00:00","utc_offset_seconds":-14400}},"links":{"sam":"https://sam.gov/workspace/contract/opp/ec997e8bd789425b98ef5cfcfa96930b/view"},"naics":{"codes":["541380"],"primary":"541380"},"title":"NINDS Division Translational Research – Rodent Pharmacokinetic (PK) Studies","agency":{"office":{"code":"75N950","name":"NATIONAL INSTITUTES OF HEALTH NIDA"},"subtier":{"code":"7529","name":"NATIONAL INSTITUTES OF HEALTH"},"department":{"code":"075","name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF"},"office_address":{"zip":"20892","city":"Bethesda","state":"MD","country":"USA"},"organization_type":"OFFICE"},"status":{"active":false,"archive_date":"2024-08-13","archive_type":"auto15"},"contacts":[{"name":"Sneha Singh","role":"primary","email":"sneha.singh@nih.gov"}],"base_type":{"code":"r","label":"Sources Sought"},"notice_id":"ec997e8bd789425b98ef5cfcfa96930b","provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/Archived%20Data/FY2024_archived_opportunities.csv","etag":"\"d582488fe153a9f11bf629913d176ffc-137\"","fetched_at":"2026-09-16T19:07:39.720164Z","row_sha256":"9bcb5ca8b2c208f475dccbc38dcf12825501fb682e019097cb0702f50ffa38e7","last_modified":"2026-09-13T14:47:40Z"},"updated_at":"2026-09-16T19:07:39.720164Z","first_seen_at":"2026-09-16T19:07:39.720164Z"},"description":{"text":"COMBINED SYNOPSIS / SOLICITATION COMPETITIVE Title: NINDS Division Translational Research – Rodent Pharmacokinetic (PK) Testing Services This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. **PLEASE SEE ATTACHMENTS FOR ADDITIONAL INFORMATION.** Attachments: Combined Synopsis Solicitation Attachment 1 – Statement of Work Attachment 2 – Technical Evaluation Criteria Attachment 3 – Terms & Conditions Attachment 4 – FAR 52.212-5 Attachment 5 – VAS Worksheet Attachment 6 – Invoice Instructions","origin":"extract"},"notice_type":{"code":"k","label":"Combined Synopsis/Solicitation"},"schema_version":1,"solicitation_number":"75N95024R00062","place_of_performance":{"city":{"name":"Bethesda"},"state":{"code":"MD"},"country":{"code":"USA"}},"product_service_code":"Q301"},{"dates":{"posted":"2024-07-24","response_deadline":{"raw":"2024-07-29T11:00:00-04:00","utc":"2024-07-29T15:00:00Z","date":"2024-07-29","time":"11:00:00","utc_offset_seconds":-14400}},"links":{"sam":"https://sam.gov/workspace/contract/opp/7bbad31262064ff28f97b606ca4a05a4/view"},"naics":{"codes":["541380"],"primary":"541380"},"title":"NINDS Division Translational Research – Rodent Pharmacokinetic (PK) Studies","agency":{"office":{"code":"75N950","name":"NATIONAL INSTITUTES OF HEALTH NIDA"},"subtier":{"code":"7529","name":"NATIONAL INSTITUTES OF HEALTH"},"department":{"code":"075","name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF"},"office_address":{"zip":"20892","city":"Bethesda","state":"MD","country":"USA"},"organization_type":"OFFICE"},"status":{"active":false,"archive_date":"2024-08-13","archive_type":"auto15"},"contacts":[{"name":"Sneha Singh","role":"primary","email":"sneha.singh@nih.gov"}],"base_type":{"code":"k","label":"Combined Synopsis/Solicitation"},"notice_id":"7bbad31262064ff28f97b606ca4a05a4","provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/Archived%20Data/FY2024_archived_opportunities.csv","etag":"\"d582488fe153a9f11bf629913d176ffc-137\"","fetched_at":"2026-09-16T19:07:39.720164Z","row_sha256":"cf9f4e941cd08183823676647f22455145a83628a23c0586aa26714eac22b917","last_modified":"2026-09-13T14:47:40Z"},"updated_at":"2026-09-16T19:07:39.720164Z","first_seen_at":"2026-09-16T19:07:39.720164Z"},"description":{"text":"Amendment 1 NINDS Division Translational Research – Rodent Pharmacokinetic (PK) Testing Services The purpose of this amendment is to replace Attachment 1: Statement of Work, with the revised, Attachment 1: Statement of Work, Amendment I, dated July 24, 2024. Please see the revisions highlighted in yellow in the attachment, Statement of Work, Amendment I There is no extension to the offer due date. Offers are due July 29, 2024 11:00 am EDT. ----------------------- COMBINED SYNOPSIS / SOLICITATION COMPETITIVE Title: NINDS Division Translational Research – Rodent Pharmacokinetic (PK) Testing Services This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. **PLEASE SEE ATTACHMENTS FOR ADDITIONAL INFORMATION.** Attachments: Combined Synopsis Solicitation Attachment 1 – Statement of Work Attachment 2 – Technical Evaluation Criteria Attachment 3 – Terms & Conditions Attachment 4 – FAR 52.212-5 Attachment 5 – VAS Worksheet Attachment 6 – Invoice Instructions","origin":"extract"},"notice_type":{"code":"k","label":"Combined Synopsis/Solicitation"},"schema_version":1,"solicitation_number":"75N95024R00062","place_of_performance":{"city":{"name":"Bethesda"},"state":{"code":"MD"},"country":{"code":"USA"}},"product_service_code":"Q301"},{"award":{"date":"2024-08-23","amount":"129586.25","number":"75N95024P00495","awardee":{"raw":"MELIOR DISCOVERY INC Exton PA 19341 USA","name":"MELIOR DISCOVERY INC Exton","location":{"zip":"19341","state":{"code":"PA"},"country":{"code":"USA"}}}},"dates":{"posted":"2024-09-09","award_date":"2024-08-23"},"links":{"sam":"https://sam.gov/workspace/contract/opp/d96fd03e72a1455bbad729f7876461ba/view"},"naics":{"codes":["541380"],"primary":"541380"},"title":"NINDS Division Translational Research – Rodent Pharmacokinetic (PK) Studies","agency":{"office":{"code":"75N950","name":"NATIONAL INSTITUTES OF HEALTH NIDA"},"subtier":{"code":"7529","name":"NATIONAL INSTITUTES OF HEALTH"},"department":{"code":"075","name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF"},"office_address":{"zip":"20892","city":"Bethesda","state":"MD","country":"USA"},"organization_type":"OFFICE"},"status":{"active":false,"archive_date":"2024-09-26","archive_type":"auto_custom"},"contacts":[{"name":"Sneha Singh","role":"primary","email":"sneha.singh@nih.gov"}],"base_type":{"code":"k","label":"Combined Synopsis/Solicitation"},"notice_id":"d96fd03e72a1455bbad729f7876461ba","provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/Archived%20Data/FY2024_archived_opportunities.csv","etag":"\"d582488fe153a9f11bf629913d176ffc-137\"","fetched_at":"2026-09-16T19:07:39.720164Z","row_sha256":"0c67a40d8ae6ef39bf617be32cb4b248ccc76843c7491f5dc842fef35905b49b","last_modified":"2026-09-13T14:47:40Z"},"updated_at":"2026-09-16T19:07:39.720164Z","first_seen_at":"2026-09-16T19:07:39.720164Z"},"description":{"text":"Thank you for your interest!","origin":"extract"},"notice_type":{"code":"a","label":"Award Notice"},"schema_version":1,"solicitation_number":"75N95024R00062","place_of_performance":{"city":{"name":"Bethesda"},"state":{"code":"MD"},"country":{"code":"USA"}},"product_service_code":"Q301"}],"due_at":"2024-07-29T15:00:00Z","due_date":"2024-07-29","closes_at":"2024-07-29T15:00:00Z","awardable":false,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N950","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","state":"MD","county":"24031","county_name":"Montgomery County","city":"2407125","city_name":"Bethesda","country":"USA","winner_key":"JNDKU5RMVAT4","amount":"129586.25","linked_awards":10,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z","principal_notice_id":"d96fd03e72a1455bbad729f7876461ba","description":{"text":"Thank you for your interest!","html":null,"origin":"extract"},"contacts":[{"name":"Sneha Singh","role":"primary","email":"sneha.singh@nih.gov"}],"place_of_performance":{"city":{"name":"Bethesda"},"state":{"code":"MD"},"country":{"code":"USA"}},"office_address":{"zip":"20892","city":"Bethesda","state":"MD","country":"USA"},"naics_codes":["541380"],"award":{"date":"2024-08-23","amount":"129586.25","number":"75N95024P00495","awardee":{"raw":"MELIOR DISCOVERY INC Exton PA 19341 USA","name":"MELIOR DISCOVERY INC Exton","location":{"zip":"19341","state":{"code":"PA"},"country":{"code":"USA"}}}},"attachments":[],"awards":[{"award_key":"CONT_AWD_75N95024P00226_7529_-NONE-_-NONE-","permalink":"https://www.usaspending.gov/award/CONT_AWD_75N95024P00226_7529_-NONE-_-NONE-/","piid":"75N95024P00226","parent_piid":null,"award_type":"PURCHASE ORDER","vendor_key":"JNDKU5RMVAT4","recipient_name":"BLACKROCK MICROSYSTEMS, INC","recipient_uei":"JNDKU5RMVAT4","recipient_cage":"54M56","recipient_city":"SALT LAKE CITY","recipient_state":"UT","sub_name":"National Institutes of Health","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","office_key":"o-75N950","first_action_date":"2024-04-11","last_action_date":"2024-04-11","actions":1,"obligated":"245000.00","current_total_value":"245000.00","potential_total_value":"245000.00","naics":"334516","psc":"6515","extent_competed":"NOT COMPETED UNDER SAP","set_aside":"NO SET ASIDE USED.","offers_received":1,"description":"BLACKROCK NEUROPORT EEG WITH TRADE-IN","method":"solicitation","confidence":"high","evidence":["solicitation number 75N95024R00062 equals the FPDS solicitation identifier","same awarding office 75N950"],"opportunity_key":null,"opportunity_title":null},{"award_key":"CONT_AWD_75N95024P00495_7529_-NONE-_-NONE-","permalink":"https://www.usaspending.gov/award/CONT_AWD_75N95024P00495_7529_-NONE-_-NONE-/","piid":"75N95024P00495","parent_piid":null,"award_type":"PURCHASE ORDER","vendor_key":"XS2QB3V9VQT4","recipient_name":"MELIOR DISCOVERY INC","recipient_uei":"XS2QB3V9VQT4","recipient_cage":"5D6P7","recipient_city":"EXTON","recipient_state":"PA","sub_name":"National Institutes of Health","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","office_key":"o-75N950","first_action_date":"2024-08-23","last_action_date":"2024-08-23","actions":1,"obligated":"77230.25","current_total_value":"77230.25","potential_total_value":"129586.25","naics":"541380","psc":"Q301","extent_competed":"COMPETED UNDER SAP","set_aside":"NO SET ASIDE USED.","offers_received":6,"description":"MELIOR - PTTP PK STUDIES","method":"solicitation","confidence":"high","evidence":["solicitation number 75N95024R00062 equals the FPDS solicitation identifier","same awarding office 75N950"],"opportunity_key":null,"opportunity_title":null}],"related":[{"key":"75N98026Q01128","latest_notice_id":"bb06bb3df12b41368577717da748025d","title":"Account Management, Planning, and Maintenance for Online Crowd-Sourced Surveys and Cognitive Tasks for Individuals","solicitation_number":"75N98026Q01128","notice_type":"k","first_type":"r","first_posted":"2026-09-01","last_posted":"2026-09-16","notices":2,"due_at":"2026-09-21T13:00:00Z","due_date":"2026-09-21","closes_at":"2026-09-21T13:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N950","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","naics":"541990","psc":"R499","set_aside":null,"state":"MD","county":"24031","county_name":"Montgomery County","city":"2407125","city_name":"Bethesda","country":"USA","winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-17T06:28:38.602097Z"},{"key":"75N98026R00157SB","latest_notice_id":"ee510f1cce674a259b707473c3e23234","title":"CTN Data, Statistics, and Clinical Trial Support Center (DSC7)","solicitation_number":"75N98026R00157SB","notice_type":"r","first_type":"r","first_posted":"2026-09-09","last_posted":"2026-09-09","notices":1,"due_at":"2026-09-30T17:00:00Z","due_date":"2026-09-30","closes_at":"2026-09-30T17:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N950","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","naics":"541715","psc":"AN11","set_aside":"SBA","state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z"},{"key":"75N98026R00157OT","latest_notice_id":"a367c8ec486d4b1fa7709ac1c2c6e019","title":"CTN Data, Statistics, and Clinical Trial Support Center (DSC7)","solicitation_number":"75N98026R00157OT","notice_type":"r","first_type":"r","first_posted":"2026-09-09","last_posted":"2026-09-09","notices":1,"due_at":"2026-09-30T17:00:00Z","due_date":"2026-09-30","closes_at":"2026-09-30T17:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N950","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","naics":"541715","psc":"AN11","set_aside":null,"state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z"},{"key":"75N95026R00003","latest_notice_id":"180e97fe5cab4693b99f561c5ede9778","title":"Data Access Program","solicitation_number":"75N95026R00003","notice_type":"p","first_type":"p","first_posted":"2025-12-15","last_posted":"2025-12-15","notices":2,"due_at":"2026-12-30T18:00:00Z","due_date":"2026-12-30","closes_at":"2026-12-30T18:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N950","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","naics":"541611","psc":"R499","set_aside":null,"state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z"}]}