{"canonical":"https://abierto.us/opportunities/75n95024q00274","key":"75N95024Q00274","url":"https://abierto.us/opportunities/75n95024q00274","title":"Flow Cytometry Instrument","solicitation_number":"75N95024Q00274","notice_type":"k","open":false,"response_deadline":"2024-07-01T15:00:00Z","first_posted":"2024-05-03","last_posted":"2024-06-17","department":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","subagency":"NATIONAL INSTITUTES OF HEALTH","office":"NATIONAL INSTITUTES OF HEALTH NIDA","naics":"334516","psc":"6640","set_aside":null,"place_state":"MD","place_county":"24031","place_county_name":"Montgomery County","place_city":"2407125","place_city_name":"Bethesda","winner":null,"award_amount":null,"publications":[{"notice_id":"c30e61d82586420fa31c87df1f13444f","title":"SOURCES SOUGHT: Flow Cytometry Instrument","solicitation_number":"75N95024Q00274","notice_type":"r","base_type":"r","posted":"2024-05-03","posted_at":null,"due_at":"2024-05-17T15:00:00Z","due_date":"2024-05-17","cancelled":null,"archived":null,"archive_date":"2024-06-01","award_number":null,"awardee_name":null,"amount":null,"link_sam":"https://sam.gov/workspace/contract/opp/c30e61d82586420fa31c87df1f13444f/view","enriched":false,"history":[]},{"notice_id":"25cbef65572c4dd6957eae969abc3f8a","title":"Flow Cytometry Instrument","solicitation_number":"75N95024Q00274","notice_type":"k","base_type":"k","posted":"2024-06-17","posted_at":null,"due_at":"2024-07-01T15:00:00Z","due_date":"2024-07-01","cancelled":null,"archived":null,"archive_date":"2024-07-16","award_number":null,"awardee_name":null,"amount":null,"link_sam":"https://sam.gov/workspace/contract/opp/25cbef65572c4dd6957eae969abc3f8a/view","enriched":false,"history":[]}],"latest_notice_id":"25cbef65572c4dd6957eae969abc3f8a","first_type":"r","notices":[{"dates":{"posted":"2024-05-03","response_deadline":{"raw":"2024-05-17T11:00:00-04:00","utc":"2024-05-17T15:00:00Z","date":"2024-05-17","time":"11:00:00","utc_offset_seconds":-14400}},"links":{"sam":"https://sam.gov/workspace/contract/opp/c30e61d82586420fa31c87df1f13444f/view"},"naics":{"codes":["334516"],"primary":"334516"},"title":"SOURCES SOUGHT: Flow Cytometry Instrument","agency":{"office":{"code":"75N950","name":"NATIONAL INSTITUTES OF HEALTH NIDA"},"subtier":{"code":"7529","name":"NATIONAL INSTITUTES OF HEALTH"},"department":{"code":"075","name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF"},"office_address":{"zip":"20892","city":"Bethesda","state":"MD","country":"USA"},"organization_type":"OFFICE"},"status":{"active":false,"archive_date":"2024-06-01","archive_type":"auto15"},"contacts":[{"name":"Hashim Dasti","role":"primary","email":"hashim.dasti@nih.gov","phone":"3014028225"}],"base_type":{"code":"r","label":"Sources Sought"},"notice_id":"c30e61d82586420fa31c87df1f13444f","provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/Archived%20Data/FY2024_archived_opportunities.csv","etag":"\"d582488fe153a9f11bf629913d176ffc-137\"","fetched_at":"2026-09-16T19:07:39.720164Z","row_sha256":"efa1f649b6814fc67d3aa522a1024b3ff7d52a135dfd96680ebc0671e69d6f6d","last_modified":"2026-09-13T14:47:40Z"},"updated_at":"2026-09-16T19:07:39.720164Z","first_seen_at":"2026-09-16T19:07:39.720164Z"},"description":{"text":"This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement, to determine the method of acquisition, and availability of domestic sources manufactured in the United States in sufficient and reasonably available commercial quantities and of a satisfactory quality. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Small businesses are encouraged to respond. For equipment/supply requirements, small business responses must include: (1) the place of manufacturing (i.e. address if supply/equipment is a domestic end product and include country of manufacture), as well as (2) the size status of the manufacturer under the applicable NAICS code (i.e. address Non-Manufacturer Rule). Background: The Center for Alzheimer’s Disease and Related Dementias (CARD) works to understand the pathological basis of neurodegenerative diseases. The purpose of this acquisition is to provide a flow cytometry instrument to analyze single cells which can be paired with down stream single cell technologies. Purpose and Objectives: This acquisition is necessary for the preparation and analysis of single cells to support neurodegenerative disease research within the Center for Alzheimer’s Disease and Related Dementias. Project requirements: Cell sorter must be able to provide the following features. Lasers and Optics 488-nm blue laser, violet 405nm and red 640nm laser parameter plus FSC, SSC for a total 11 parameters FSC, SSC, and 9 colors. Spatially separated beams each with its own unique optical channel. Laser Beam Alignment Laser and optical alignments with fixed alignments (no stepper motors) and require no user alignment. Optical coupling The quartz cuvette flow cell is gel-coupled by refractive index matching optical gel to the fluorescence. Detection channels Forward scatter (FSC), side scatter (SSC) and up to nine fluorescence channels. Fluidics 5.0-mL polystyrene or polypropylene tubes can be used. Temperature control: Adjustable through software: 4°C, 22°C, 37°C and 42°C or off. Sample agitation: Adjustable through the software to keep the sample constantly suspended Sample flow automatically stops when the sample input tube is empty. 100-µm nozzle is removable and can be sonicated. A registered key-fit position at the bottom of the cuvette provides fixed stream alignment requiring no optical/laser system alignment Autoclavable 10-L stainless steel sheath container. 10-L polypropylene waste container Performance Time from system power up to running sample, including powerup, fluidic startup, stream optimization and optional performance checks (instrument and drop delay QC): <20 minutes; excluding optional performance checks: <10 minutes. Sorting nozzle tip can be removed during operation, replaced and stream optimized: <3 minutes. Fluorescence sensitivity FITC: <110 molecules of equivalent soluble fluorochrome (MESF-FITC). PE: <30 molecules of equivalent soluble fluorochrome (MESF-PE). Fluorescent detection efficiency: FITC Qr (x1,000): 40 photoelectrons/ABD PE Qr (x1,000): 325 photoelectrons/ABD CD4 FITC: 1,600 photoelectrons* CD4 PE: 13,000 photoelectrons* Fluorescence resolution Full-peak coefficient of variation (FPCV): <3.0%, G0/G1 peak for propidium iodide (PI)-stained chicken erythrocyte nuclei (CEN). Forward and side scatter sensitivity Sensitivity enables separation of 0.5-µm beads from noise. Forward and side scatter resolution Scatter performance is optimized for resolving lymphocytes, monocytes and granulocytes. Droplet Sorting Droplet sorting 34,000 drops per second Automated setup, optimization and monitoring of droplet breakoff and sort streams Automated drop-delay determination with BD FACS™ Accudrop beads Automated clog detection and sort tube protection system using Sweet Spot technology Optical filters with electronic identifier chips that communicate with computer updating system configuration after a filter change. Purity and Yield At 23 psi and 34 kHz with an average of 10,000 events per second, a 4-way sort of 5% target populations achieved a purity of 98% and a yield of >80% of Poisson’s expected yield for all four populations. No limitation is imposed on the event rate. However, yield decreases with higher event rates based on Poisson distribution principles. Similar results are observed for 2-way sorts. Sort collection 4-way sorting: 1.5-, 2.0-, and 5.0-mL tubes 2-way sorting: 1.5-, 2.0- and 5.0-mL tubes 1-way sorting: 6-, 24-, 48-, 96- and 384-well plates, 96-well PCR tray, microscope slide (optional) Temperature control: water recirculation unit to provide heating or cooling for collection into tube holders, multiwell plates and slides (optional) Index Sorting Correlation of flow cytometry parameters of sorted events with well location of a multiwell plate, tray or slide (standard feature enabled with optional plate sorting). Operating System Business PC with at minimum: Intel® 2.8G CPU Quad Core™ i7, Microsoft® Windows® 10 64-bit operating system Monitor 23-inch LCD with a minimum 1920 x 1080 resolution Memory 8-GB RAM Storage 500-GB hard drive Plate Sorting Software controlled single or multiple cell deposition, one-way sorting: Plates: 6-, 24-, 48-, 96- and 384-well plates • PCR tray: 96 well • Microscope slide: 3 x 9 grid Sample and temperature control Sample temperature control Water recirculation unit and sort collection devices to provide heating or cooling of tubes, multiwell plates and slides during sorting. Anticipated period of performance: 6 months ARO Other important considerations: In case domestic sources are available and capable of fulfilling the Government’s need, and a future solicitation is published, the Government will use evaluation preferences in accordance with FAR 25. Capability statement /information sought. Companies that believe they possess the capabilities to provide the required products should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately. Additionally, the capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the requirements outlined, 3) any contractor GSA Schedule contracts and/or other government-wide acquisition contracts (GWACs) by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Capability statements must also include the Company Name, Unique Entity ID from SAM.gov, Physical Address, and Point of Contact Information. The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. Interested companies are required to identify their type of business, applicable North American Industry Classification System (NAICS) Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2” x 11” paper size, with 1” top, bottom, left and right margins, and with single or double spacing. The information submitted must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer. Facsimile responses are NOT accepted. The response must be submitted to Hashim Dasti, Contract Specialist, at hashim.dasti@nih.gov. The response must be received on or before May 17, 2024 at 11AM Eastern Time. Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in www.sam.gov. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).","origin":"extract"},"notice_type":{"code":"r","label":"Sources Sought"},"schema_version":1,"solicitation_number":"75N95024Q00274","place_of_performance":{"zip":"20892","city":{"name":"Bethesda"},"state":{"code":"MD"},"country":{"code":"USA"}},"product_service_code":"6640"},{"dates":{"posted":"2024-06-17","response_deadline":{"raw":"2024-07-01T11:00:00-04:00","utc":"2024-07-01T15:00:00Z","date":"2024-07-01","time":"11:00:00","utc_offset_seconds":-14400}},"links":{"sam":"https://sam.gov/workspace/contract/opp/25cbef65572c4dd6957eae969abc3f8a/view"},"naics":{"codes":["334516"],"primary":"334516"},"title":"Flow Cytometry Instrument","agency":{"office":{"code":"75N950","name":"NATIONAL INSTITUTES OF HEALTH NIDA"},"subtier":{"code":"7529","name":"NATIONAL INSTITUTES OF HEALTH"},"department":{"code":"075","name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF"},"office_address":{"zip":"20892","city":"Bethesda","state":"MD","country":"USA"},"organization_type":"OFFICE"},"status":{"active":false,"archive_date":"2024-07-16","archive_type":"auto15"},"contacts":[{"name":"Hashim Dasti","role":"primary","email":"hashim.dasti@nih.gov","phone":"3014028225"}],"base_type":{"code":"k","label":"Combined Synopsis/Solicitation"},"notice_id":"25cbef65572c4dd6957eae969abc3f8a","provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/Archived%20Data/FY2024_archived_opportunities.csv","etag":"\"d582488fe153a9f11bf629913d176ffc-137\"","fetched_at":"2026-09-16T19:07:39.720164Z","row_sha256":"014de41384c87b8ff321caa7634abae0f20832c7029851997cb77eaa4d5140a6","last_modified":"2026-09-13T14:47:40Z"},"updated_at":"2026-09-16T19:07:39.720164Z","first_seen_at":"2026-09-16T19:07:39.720164Z"},"description":{"text":"(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. (ii) The solicitation number is 75N95024Q00274 and the solicitation is issued as a request for quotation (RFQ). This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13—Simplified Acquisition Procedures; FAR Subpart 13.5— Simplified Procedures for Certain Commercial Items; and FAR Part 12—Acquisition of Commercial Items, and is expected to exceed the simplified acquisition threshold. (iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC) Number 2024-05, with effective date May 22, 2024. (iv) The associated NAICS code 334516 – Analytical Laboratory Instrument Manufacturing and the small business size standard is 1,000 employees. This requirement is Brand Name or Equal, full and open with no set-aside restrictions. (v) This requirement is for a BD Biosciences (or equal) Flow Cytometry Instrument Description: Cat no: Quantity BD FACSMelody 2024-92931 v1 1.00 (vi) The Center for Alzheimer’s Disease and Related Dementias (CARD) works to understand the pathological basis of neurodegenerative diseases. The purpose of this acquisition is to provide a flow cytometry instrument to analyze single cells which can be paired with down stream single cell technologies. Cell sorter must be able to provide the following features. Lasers and Optics 488-nm blue laser, violet 405nm and red 640nm laser parameter plus FSC, SSC for a total 11 parameters FSC, SSC, and 9 colors. Spatially separated beams each with its own unique optical channel. Laser Beam Alignment Laser and optical alignments with fixed alignments (no stepper motors) and require no user alignment. Optical coupling The quartz cuvette flow cell is gel-coupled by refractive index matching optical gel to the fluorescence. Detection channels Forward scatter (FSC), side scatter (SSC) and up to nine fluorescence channels. Fluidics 5.0-mL polystyrene or polypropylene tubes can be used. Temperature control: Adjustable through software: 4°C, 22°C, 37°C and 42°C or off. Sample agitation: Adjustable through the software to keep the sample constantly suspended Sample flow automatically stops when the sample input tube is empty. 100-µm nozzle is removable and can be sonicated. A registered key-fit position at the bottom of the cuvette provides fixed stream alignment requiring no optical/laser system alignment Autoclavable 10-L stainless steel sheath container. 10-L polypropylene waste container Performance Time from system power up to running sample, including powerup, fluidic startup, stream optimization and optional performance checks (instrument and drop delay QC): <20 minutes; excluding optional performance checks: <10 minutes. Sorting nozzle tip can be removed during operation, replaced and stream optimized: <3 minutes. Fluorescence sensitivity FITC: <110 molecules of equivalent soluble fluorochrome (MESF-FITC). PE: <30 molecules of equivalent soluble fluorochrome (MESF-PE). Fluorescent detection efficiency: FITC Qr (x1,000): 40 photoelectrons/ABD PE Qr (x1,000): 325 photoelectrons/ABD CD4 FITC: 1,600 photoelectrons* CD4 PE: 13,000 photoelectrons* Fluorescence resolution Full-peak coefficient of variation (FPCV): <3.0%, G0/G1 peak for propidium iodide (PI)-stained chicken erythrocyte nuclei (CEN). Forward and side scatter sensitivity Sensitivity enables separation of 0.5-µm beads from noise. Forward and side scatter resolution Scatter performance is optimized for resolving lymphocytes, monocytes and granulocytes. Droplet Sorting Droplet sorting 34,000 drops per second Automated setup, optimization and monitoring of droplet breakoff and sort streams Automated drop-delay determination with BD FACS™ Accudrop beads Automated clog detection and sort tube protection system using Sweet Spot technology Optical filters with electronic identifier chips that communicate with computer updating system configuration after a filter change. Purity and Yield At 23 psi and 34 kHz with an average of 10,000 events per second, a 4-way sort of 5% target populations achieved a purity of 98% and a yield of >80% of Poisson’s expected yield for all four populations. No limitation is imposed on the event rate. However, yield decreases with higher event rates based on Poisson distribution principles. Similar results are observed for 2-way sorts. Sort collection 4-way sorting: 1.5-, 2.0-, and 5.0-mL tubes 2-way sorting: 1.5-, 2.0- and 5.0-mL tubes 1-way sorting: 6-, 24-, 48-, 96- and 384-well plates, 96-well PCR tray, microscope slide (optional) Temperature control: water recirculation unit to provide heating or cooling for collection into tube holders, multiwell plates and slides (optional) Index Sorting Correlation of flow cytometry parameters of sorted events with well location of a multiwell plate, tray or slide (standard feature enabled with optional plate sorting). Operating System Business PC with at minimum: Intel® 2.8G CPU Quad Core™ i7, Microsoft® Windows® 10 64-bit operating system Monitor 23-inch LCD with a minimum 1920 x 1080 resolution Memory 8-GB RAM Storage 500-GB hard drive Plate Sorting Software controlled single or multiple cell deposition, one-way sorting: Plates: 6-, 24-, 48-, 96- and 384-well plates • PCR tray: 96 well • Microscope slide: 3 x 9 grid Sample and temperature control Sample temperature control Water recirculation unit and sort collection devices to provide heating or cooling of tubes, multiwell plates and slides during sorting. Class II Type A2 biological safety cabinet Specially modified Baker SterilGARD® e3 Class II, Type A2 biological safety cabinet (BSC) verified to meet personnel and product protection standards for Class II Type A2 with a BD FACSMelody Cell Sorter installed in the work area. Aerosol Management Option (AMO) for systems without the BSC The BD FACSMelody Sorter features an enclosed pathway from the sample injection chamber to the sort collection tubes. For an added level of aerosol management, the BD Aerosol Management Option evacuates the sort collection chamber and traps aerosolized particles during sorting. It is equipped with a 0.01-µm size ultra-low penetrating air (ULPA) filter to trap aerosolized particles. Warranty 12 months manufacturer maintenance and repair service with guaranteed on-site emergency service with in 48 hours of initial request. Quantity: One (1) All deliverables required under this contract shall be packaged, marked and shipped in accordance with Government specifications. At a minimum, all deliverables shall be marked with the contract number and Contractor name. The Contractor shall guarantee that all required materials shall be delivered in immediate usable and acceptable condition. (vii) The Government anticipates award of a firm fixed-price purchase order for this acquisition, and the anticipated delivery date is 60 days after receipt of order (ARO). Delivery will be f.o.b. destination. The place of delivery and acceptance will be 9000 Rockville Pike; Bldg. T44, Bethesda, MD 20892. (viii) The provision at FAR 52.252-1, Solicitation Provisions Incorporated by Reference (Feb 1998), applies to this acquisition. This solicitation incorporates one or more solicitation provisions by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. The offeror is cautioned that the listed provisions may include blocks that must be completed by the offeror and submitted with its quotation or offer. In lieu of submitting the full text of those provisions, the offeror may identify the provision by paragraph identifier and provide the appropriate information with its quotation or offer. Also, the full text of a solicitation provision may be accessed electronically at these addresses: https://www.acquisition.gov/browse/index/far https://www.hhs.gov/grants/contracts/contract-policies-regulations/hhsar/index.html (End of provision) The following provisions apply to this acquisition and are incorporated by reference: FAR 52.204-7, System for Award Management (Oct 2018) FAR 52.204-16, Commercial and Government Entity Code Reporting (Aug 2020) FAR 52.204-29, Federal Acquisition Supply Chain Security Act Orders – Representation and Disclosures (Dec 2023) FAR 52.211-6, Brand Name or Equal (Aug 1999) FAR 52.212-1, Instructions to Offerors-Commercial Products and Commercial Services (Sep 2023) FAR 52.212-3, Offeror Representations and Certifications-Commercial Products and Commercial Services (Feb 2024) FAR 52.225-2, Buy American Certificate (Oct 2022) HHSAR 352.239-73, Electronic and Information Technology Accessibility Notice (December 18, 2015) The clause at FAR 52.252-2, Clauses Incorporated by Reference (Feb 1998), applies to this acquisition. This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed electronically at these addresses: https://www.acquisition.gov/browse/index/far https://www.hhs.gov/grants/contracts/contract-policies-regulations/hhsar/index.html (End of clause) The following clauses apply to this acquisition and are incorporated by reference: FAR 52.204-13, System for Award Management Maintenance (Oct 2018) FAR 52.204-18, Commercial and Government Entity Code Maintenance (Aug 2020) FAR 52.212-4, Contract Terms and Conditions—Commercial Products and Commercial Services (Nov 2023). Addendum to this FAR clause applies to this acquisition and is attached. HHSAR 352.222-70, Contractor Cooperation in Equal Employment Opportunity Investigations (December 18, 2015) HHSAR 352.239-74, Electronic and Information Technology Accessibility (December 18, 2015) The following provisions and clauses apply to this acquisition and are attached in full text. Offerors MUST complete the provisions below and submit completed copies as separate documents with their proposal. FAR 52.204-24 Representation Regarding Certain Telecommunications and Video Surveillance Services or Equipment (Nov 2021) FAR 52.204-26 Covered Telecommunications Equipment or Services-Representation (Oct 2020) FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders--Commercial Products and Commercial Services (May 2024) FAR 52.225-6, Trade Agreements Certificate (Feb 2021) NIH Invoice and Payment Provisions (ix) The Government will evaluate quotations or offers in accordance with FAR 13.106-2 and award a purchase order from this solicitation to the responsible offeror whose quote conforming to the solicitation will be most advantageous to the Government, price and other factors considered. The following factors shall be used to evaluate quotes: a. Technical capability of the item offered to meet the Government requirement; b. Price; and c. Past performance [see FAR 13.106-2(b)(3)]. Technical and past performance, when combined, are significantly more important than cost or price. A written notice of award or acceptance of an offer, mailed or otherwise furnished to the successful offeror within the time for acceptance specified in the offer, shall result in a binding contract without further action by either party. Before the offer’s specified expiration time, the Government may accept an offer (or part of an offer), whether or not there are negotiations after its receipt, unless a written notice of withdrawal is received before award. (x) Offerors must include a completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications—Commercial Products and Commercial Services (Feb 2024), with its offer. If the offeror has completed FAR clause 52.212-3 at www.sam.gov, then the offeror does not need to provide a completed copy with its offer. (xi) There are no additional contract requirement(s) or terms and conditions applicable to this acquisition. (xii) The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. (xii) Responses to this solicitation must include sufficient information to establish the interested parties’ bona-fide capabilities of providing the product or service. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s), product description, and any other information or factors that may be considered in the award decision. Such factors may include: past performance, special features required for effective program performance, trade-in considerations, probable life of the item selected as compared with that of a comparable item, warranty considerations, maintenance availability, and environmental and energy efficiency considerations. The Unique Entity ID from SAM.gov, the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. All quotations must be received by 11:00 A.M. Eastern, on July 1, 2024, and reference Solicitation Number 75N95024Q00274. Responses must be submitted electronically to Hashim Dasti, Contract Specialist, at hashim.dasti@nih.gov. Fax responses will not be accepted.","origin":"extract"},"notice_type":{"code":"k","label":"Combined Synopsis/Solicitation"},"schema_version":1,"solicitation_number":"75N95024Q00274","place_of_performance":{"zip":"20892","city":{"name":"Bethesda"},"state":{"code":"MD"},"country":{"code":"USA"}},"product_service_code":"6640"}],"due_at":"2024-07-01T15:00:00Z","due_date":"2024-07-01","closes_at":"2024-07-01T15:00:00Z","awardable":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N950","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","state":"MD","county":"24031","county_name":"Montgomery County","city":"2407125","city_name":"Bethesda","country":"USA","winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z","principal_notice_id":"25cbef65572c4dd6957eae969abc3f8a","description":{"text":"(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. (ii) The solicitation number is 75N95024Q00274 and the solicitation is issued as a request for quotation (RFQ). This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13—Simplified Acquisition Procedures; FAR Subpart 13.5— Simplified Procedures for Certain Commercial Items; and FAR Part 12—Acquisition of Commercial Items, and is expected to exceed the simplified acquisition threshold. (iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC) Number 2024-05, with effective date May 22, 2024. (iv) The associated NAICS code 334516 – Analytical Laboratory Instrument Manufacturing and the small business size standard is 1,000 employees. This requirement is Brand Name or Equal, full and open with no set-aside restrictions. (v) This requirement is for a BD Biosciences (or equal) Flow Cytometry Instrument Description: Cat no: Quantity BD FACSMelody 2024-92931 v1 1.00 (vi) The Center for Alzheimer’s Disease and Related Dementias (CARD) works to understand the pathological basis of neurodegenerative diseases. The purpose of this acquisition is to provide a flow cytometry instrument to analyze single cells which can be paired with down stream single cell technologies. Cell sorter must be able to provide the following features. Lasers and Optics 488-nm blue laser, violet 405nm and red 640nm laser parameter plus FSC, SSC for a total 11 parameters FSC, SSC, and 9 colors. Spatially separated beams each with its own unique optical channel. Laser Beam Alignment Laser and optical alignments with fixed alignments (no stepper motors) and require no user alignment. Optical coupling The quartz cuvette flow cell is gel-coupled by refractive index matching optical gel to the fluorescence. Detection channels Forward scatter (FSC), side scatter (SSC) and up to nine fluorescence channels. Fluidics 5.0-mL polystyrene or polypropylene tubes can be used. Temperature control: Adjustable through software: 4°C, 22°C, 37°C and 42°C or off. Sample agitation: Adjustable through the software to keep the sample constantly suspended Sample flow automatically stops when the sample input tube is empty. 100-µm nozzle is removable and can be sonicated. A registered key-fit position at the bottom of the cuvette provides fixed stream alignment requiring no optical/laser system alignment Autoclavable 10-L stainless steel sheath container. 10-L polypropylene waste container Performance Time from system power up to running sample, including powerup, fluidic startup, stream optimization and optional performance checks (instrument and drop delay QC): <20 minutes; excluding optional performance checks: <10 minutes. Sorting nozzle tip can be removed during operation, replaced and stream optimized: <3 minutes. Fluorescence sensitivity FITC: <110 molecules of equivalent soluble fluorochrome (MESF-FITC). PE: <30 molecules of equivalent soluble fluorochrome (MESF-PE). Fluorescent detection efficiency: FITC Qr (x1,000): 40 photoelectrons/ABD PE Qr (x1,000): 325 photoelectrons/ABD CD4 FITC: 1,600 photoelectrons* CD4 PE: 13,000 photoelectrons* Fluorescence resolution Full-peak coefficient of variation (FPCV): <3.0%, G0/G1 peak for propidium iodide (PI)-stained chicken erythrocyte nuclei (CEN). Forward and side scatter sensitivity Sensitivity enables separation of 0.5-µm beads from noise. Forward and side scatter resolution Scatter performance is optimized for resolving lymphocytes, monocytes and granulocytes. Droplet Sorting Droplet sorting 34,000 drops per second Automated setup, optimization and monitoring of droplet breakoff and sort streams Automated drop-delay determination with BD FACS™ Accudrop beads Automated clog detection and sort tube protection system using Sweet Spot technology Optical filters with electronic identifier chips that communicate with computer updating system configuration after a filter change. Purity and Yield At 23 psi and 34 kHz with an average of 10,000 events per second, a 4-way sort of 5% target populations achieved a purity of 98% and a yield of >80% of Poisson’s expected yield for all four populations. No limitation is imposed on the event rate. However, yield decreases with higher event rates based on Poisson distribution principles. Similar results are observed for 2-way sorts. Sort collection 4-way sorting: 1.5-, 2.0-, and 5.0-mL tubes 2-way sorting: 1.5-, 2.0- and 5.0-mL tubes 1-way sorting: 6-, 24-, 48-, 96- and 384-well plates, 96-well PCR tray, microscope slide (optional) Temperature control: water recirculation unit to provide heating or cooling for collection into tube holders, multiwell plates and slides (optional) Index Sorting Correlation of flow cytometry parameters of sorted events with well location of a multiwell plate, tray or slide (standard feature enabled with optional plate sorting). Operating System Business PC with at minimum: Intel® 2.8G CPU Quad Core™ i7, Microsoft® Windows® 10 64-bit operating system Monitor 23-inch LCD with a minimum 1920 x 1080 resolution Memory 8-GB RAM Storage 500-GB hard drive Plate Sorting Software controlled single or multiple cell deposition, one-way sorting: Plates: 6-, 24-, 48-, 96- and 384-well plates • PCR tray: 96 well • Microscope slide: 3 x 9 grid Sample and temperature control Sample temperature control Water recirculation unit and sort collection devices to provide heating or cooling of tubes, multiwell plates and slides during sorting. Class II Type A2 biological safety cabinet Specially modified Baker SterilGARD® e3 Class II, Type A2 biological safety cabinet (BSC) verified to meet personnel and product protection standards for Class II Type A2 with a BD FACSMelody Cell Sorter installed in the work area. Aerosol Management Option (AMO) for systems without the BSC The BD FACSMelody Sorter features an enclosed pathway from the sample injection chamber to the sort collection tubes. For an added level of aerosol management, the BD Aerosol Management Option evacuates the sort collection chamber and traps aerosolized particles during sorting. It is equipped with a 0.01-µm size ultra-low penetrating air (ULPA) filter to trap aerosolized particles. Warranty 12 months manufacturer maintenance and repair service with guaranteed on-site emergency service with in 48 hours of initial request. Quantity: One (1) All deliverables required under this contract shall be packaged, marked and shipped in accordance with Government specifications. At a minimum, all deliverables shall be marked with the contract number and Contractor name. The Contractor shall guarantee that all required materials shall be delivered in immediate usable and acceptable condition. (vii) The Government anticipates award of a firm fixed-price purchase order for this acquisition, and the anticipated delivery date is 60 days after receipt of order (ARO). Delivery will be f.o.b. destination. The place of delivery and acceptance will be 9000 Rockville Pike; Bldg. T44, Bethesda, MD 20892. (viii) The provision at FAR 52.252-1, Solicitation Provisions Incorporated by Reference (Feb 1998), applies to this acquisition. This solicitation incorporates one or more solicitation provisions by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. The offeror is cautioned that the listed provisions may include blocks that must be completed by the offeror and submitted with its quotation or offer. In lieu of submitting the full text of those provisions, the offeror may identify the provision by paragraph identifier and provide the appropriate information with its quotation or offer. Also, the full text of a solicitation provision may be accessed electronically at these addresses: https://www.acquisition.gov/browse/index/far https://www.hhs.gov/grants/contracts/contract-policies-regulations/hhsar/index.html (End of provision) The following provisions apply to this acquisition and are incorporated by reference: FAR 52.204-7, System for Award Management (Oct 2018) FAR 52.204-16, Commercial and Government Entity Code Reporting (Aug 2020) FAR 52.204-29, Federal Acquisition Supply Chain Security Act Orders – Representation and Disclosures (Dec 2023) FAR 52.211-6, Brand Name or Equal (Aug 1999) FAR 52.212-1, Instructions to Offerors-Commercial Products and Commercial Services (Sep 2023) FAR 52.212-3, Offeror Representations and Certifications-Commercial Products and Commercial Services (Feb 2024) FAR 52.225-2, Buy American Certificate (Oct 2022) HHSAR 352.239-73, Electronic and Information Technology Accessibility Notice (December 18, 2015) The clause at FAR 52.252-2, Clauses Incorporated by Reference (Feb 1998), applies to this acquisition. This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed electronically at these addresses: https://www.acquisition.gov/browse/index/far https://www.hhs.gov/grants/contracts/contract-policies-regulations/hhsar/index.html (End of clause) The following clauses apply to this acquisition and are incorporated by reference: FAR 52.204-13, System for Award Management Maintenance (Oct 2018) FAR 52.204-18, Commercial and Government Entity Code Maintenance (Aug 2020) FAR 52.212-4, Contract Terms and Conditions—Commercial Products and Commercial Services (Nov 2023). Addendum to this FAR clause applies to this acquisition and is attached. HHSAR 352.222-70, Contractor Cooperation in Equal Employment Opportunity Investigations (December 18, 2015) HHSAR 352.239-74, Electronic and Information Technology Accessibility (December 18, 2015) The following provisions and clauses apply to this acquisition and are attached in full text. Offerors MUST complete the provisions below and submit completed copies as separate documents with their proposal. FAR 52.204-24 Representation Regarding Certain Telecommunications and Video Surveillance Services or Equipment (Nov 2021) FAR 52.204-26 Covered Telecommunications Equipment or Services-Representation (Oct 2020) FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders--Commercial Products and Commercial Services (May 2024) FAR 52.225-6, Trade Agreements Certificate (Feb 2021) NIH Invoice and Payment Provisions (ix) The Government will evaluate quotations or offers in accordance with FAR 13.106-2 and award a purchase order from this solicitation to the responsible offeror whose quote conforming to the solicitation will be most advantageous to the Government, price and other factors considered. The following factors shall be used to evaluate quotes: a. Technical capability of the item offered to meet the Government requirement; b. Price; and c. Past performance [see FAR 13.106-2(b)(3)]. Technical and past performance, when combined, are significantly more important than cost or price. A written notice of award or acceptance of an offer, mailed or otherwise furnished to the successful offeror within the time for acceptance specified in the offer, shall result in a binding contract without further action by either party. Before the offer’s specified expiration time, the Government may accept an offer (or part of an offer), whether or not there are negotiations after its receipt, unless a written notice of withdrawal is received before award. (x) Offerors must include a completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications—Commercial Products and Commercial Services (Feb 2024), with its offer. If the offeror has completed FAR clause 52.212-3 at www.sam.gov, then the offeror does not need to provide a completed copy with its offer. (xi) There are no additional contract requirement(s) or terms and conditions applicable to this acquisition. (xii) The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. (xii) Responses to this solicitation must include sufficient information to establish the interested parties’ bona-fide capabilities of providing the product or service. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s), product description, and any other information or factors that may be considered in the award decision. Such factors may include: past performance, special features required for effective program performance, trade-in considerations, probable life of the item selected as compared with that of a comparable item, warranty considerations, maintenance availability, and environmental and energy efficiency considerations. The Unique Entity ID from SAM.gov, the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. All quotations must be received by 11:00 A.M. Eastern, on July 1, 2024, and reference Solicitation Number 75N95024Q00274. Responses must be submitted electronically to Hashim Dasti, Contract Specialist, at hashim.dasti@nih.gov. Fax responses will not be accepted.","html":null,"origin":"extract"},"contacts":[{"name":"Hashim Dasti","role":"primary","email":"hashim.dasti@nih.gov","phone":"3014028225"}],"place_of_performance":{"zip":"20892","city":{"name":"Bethesda"},"state":{"code":"MD"},"country":{"code":"USA"}},"office_address":{"zip":"20892","city":"Bethesda","state":"MD","country":"USA"},"naics_codes":["334516"],"award":null,"attachments":[],"awards":[],"related":[{"key":"75N98026Q01128","latest_notice_id":"bb06bb3df12b41368577717da748025d","title":"Account Management, Planning, and Maintenance for Online Crowd-Sourced Surveys and Cognitive Tasks for Individuals","solicitation_number":"75N98026Q01128","notice_type":"k","first_type":"r","first_posted":"2026-09-01","last_posted":"2026-09-16","notices":2,"due_at":"2026-09-21T13:00:00Z","due_date":"2026-09-21","closes_at":"2026-09-21T13:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N950","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","naics":"541990","psc":"R499","set_aside":null,"state":"MD","county":"24031","county_name":"Montgomery County","city":"2407125","city_name":"Bethesda","country":"USA","winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-17T06:28:38.602097Z"},{"key":"75N98026R00157SB","latest_notice_id":"ee510f1cce674a259b707473c3e23234","title":"CTN Data, Statistics, and Clinical Trial Support Center (DSC7)","solicitation_number":"75N98026R00157SB","notice_type":"r","first_type":"r","first_posted":"2026-09-09","last_posted":"2026-09-09","notices":1,"due_at":"2026-09-30T17:00:00Z","due_date":"2026-09-30","closes_at":"2026-09-30T17:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N950","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","naics":"541715","psc":"AN11","set_aside":"SBA","state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z"},{"key":"75N98026R00157OT","latest_notice_id":"a367c8ec486d4b1fa7709ac1c2c6e019","title":"CTN Data, Statistics, and Clinical Trial Support Center (DSC7)","solicitation_number":"75N98026R00157OT","notice_type":"r","first_type":"r","first_posted":"2026-09-09","last_posted":"2026-09-09","notices":1,"due_at":"2026-09-30T17:00:00Z","due_date":"2026-09-30","closes_at":"2026-09-30T17:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N950","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","naics":"541715","psc":"AN11","set_aside":null,"state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z"},{"key":"75N95026R00003","latest_notice_id":"180e97fe5cab4693b99f561c5ede9778","title":"Data Access Program","solicitation_number":"75N95026R00003","notice_type":"p","first_type":"p","first_posted":"2025-12-15","last_posted":"2025-12-15","notices":2,"due_at":"2026-12-30T18:00:00Z","due_date":"2026-12-30","closes_at":"2026-12-30T18:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7529","sub_name":"NATIONAL INSTITUTES OF HEALTH","office_key":"o-75N950","office_name":"NATIONAL INSTITUTES OF HEALTH NIDA","naics":"541611","psc":"R499","set_aside":null,"state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z"}]}