# Screen the A10 antibody for off-target binding to plasma membrane proteins and secreted proteins

Canonical: https://abierto.us/opportunities/75n91026p00004

- Solicitation number: 75N91026P00004
- Notice type: Award notice
- Status: Awarded to Charles River Discovery Research Services UK Limited for $38,750.00
- Department: Department of Health and Human Services
- Agency: Office of the Assistant Secretary for Administration (Asa)
- Contracting office: Program Support Center Acq MGMT SVC (75P001)
- NAICS: 541380 Testing Laboratories and Services
- Product or service code: 6640 Laboratory Equipment and Supplies
- Place of performance: Saffron, GB-ESS, GBR
- First posted: February 6, 2026
- Last posted: February 6, 2026
- SAM.gov: https://sam.gov/workspace/contract/opp/1f593f2d0a2a4dc6b1e87d1efe846498/view

## Description

This is a Firm Fixed Priced purchase order. NCI solicited and negotiated directly with Charles River Discovery Research Services UK Limited. The National Cancer Institute (NCI) has a program to use an antibody called, 'A10' to target cancer cells that have a lot of the epidermal growth factor receptor on their cell surface. While this antibody has been extensively tested and characterized it is not known if it also binds any other cell surface proteins.

The contractor shall perform an off-target screen on an NCI antibody and report back on any problematic interactions that could predict a serious side effect should the antibody be given to a cancer patient. The A10 is NOT known to bind other cell surface proteins or secreted proteins but this needs to be addressed in the off-target screen.

## Award on USAspending

- Recipient: Charles River Discovery Research Services UK Limited (UEI KWY4CPWDFNT6)
- Contract: 75N91026P00004, purchase order
- Obligated: $38,750.00
- Competition: Not Competed, 1 offers received
- Link: award number 75N91026P00004 equals the contract number; awarding office not confirmed (medium confidence)
- Record: https://www.usaspending.gov/award/CONT_AWD_75N91026P00004_7529_-NONE-_-NONE-/


## Publications

- February 6, 2026: Award notice. Notice 1f593f2d0a2a4dc6b1e87d1efe846498. https://sam.gov/workspace/contract/opp/1f593f2d0a2a4dc6b1e87d1efe846498/view

## Points of contact

- Elizabeth Bulger, elizabeth.bulger@hhs.gov

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Source: SAM.gov Contract Opportunities bulk extract and USAspending.gov award data. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/75n91026p00004.