{"canonical":"https://abierto.us/opportunities/75n91026p00004","key":"75N91026P00004","url":"https://abierto.us/opportunities/75n91026p00004","title":"Screen the A10 antibody for off-target binding to plasma membrane proteins and secreted proteins","solicitation_number":"75N91026P00004","notice_type":"a","open":false,"response_deadline":null,"first_posted":"2026-02-06","last_posted":"2026-02-06","department":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","subagency":"OFFICE OF THE ASSISTANT SECRETARY FOR ADMINISTRATION (ASA)","office":"PROGRAM SUPPORT CENTER ACQ MGMT SVC","naics":"541380","psc":"6640","set_aside":null,"place_state":null,"place_county":null,"place_county_name":null,"place_city":null,"place_city_name":null,"winner":"CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED","award_amount":"38750.00","publications":[{"notice_id":"1f593f2d0a2a4dc6b1e87d1efe846498","title":"Screen the A10 antibody for off-target binding to plasma membrane proteins and secreted proteins","solicitation_number":"75N91026P00004","notice_type":"a","base_type":"a","posted":"2026-02-06","posted_at":null,"due_at":null,"due_date":null,"cancelled":null,"archived":null,"archive_date":"2026-02-11","award_number":"75N91026P00004","awardee_name":"CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED Saffron Walden CB10 1XL GBR","amount":"38750.00","link_sam":"https://sam.gov/workspace/contract/opp/1f593f2d0a2a4dc6b1e87d1efe846498/view","enriched":false,"history":[]}],"latest_notice_id":"1f593f2d0a2a4dc6b1e87d1efe846498","first_type":"a","notices":[{"award":{"date":"2026-01-27","amount":"38750.00","number":"75N91026P00004","awardee":{"raw":"CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED Saffron Walden CB10 1XL GBR","name":"CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED Saffron Walden CB10 1XL GBR"}},"dates":{"posted":"2026-02-06","award_date":"2026-01-27"},"links":{"sam":"https://sam.gov/workspace/contract/opp/1f593f2d0a2a4dc6b1e87d1efe846498/view"},"naics":{"codes":["541380"],"primary":"541380"},"title":"Screen the A10 antibody for off-target binding to plasma membrane proteins and secreted proteins","agency":{"office":{"code":"75P001","name":"PROGRAM SUPPORT CENTER ACQ MGMT SVC"},"subtier":{"code":"7570","name":"OFFICE OF THE ASSISTANT SECRETARY FOR ADMINISTRATION (ASA)"},"department":{"code":"075","name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF"},"office_address":{"zip":"20857","city":"ROCKVILLE","state":"MD","country":"USA"},"organization_type":"OFFICE"},"status":{"active":false,"archive_date":"2026-02-11","archive_type":"auto15"},"contacts":[{"name":"Elizabeth Bulger","role":"primary","email":"elizabeth.bulger@hhs.gov"}],"base_type":{"code":"a","label":"Award Notice"},"notice_id":"1f593f2d0a2a4dc6b1e87d1efe846498","provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/Archived%20Data/FY2026_archived_opportunities.csv","etag":"\"d9374b90a938e9923d910594731b7b57-106\"","fetched_at":"2026-09-16T16:22:53.920682Z","row_sha256":"96eba9d8c11a16ced7647d9520bf4d70bbb4c93cb053372b153501a33897a4e7","last_modified":"2026-09-13T14:50:39Z"},"updated_at":"2026-09-16T16:22:53.920682Z","first_seen_at":"2026-09-16T16:22:53.920682Z"},"description":{"text":"This is a Firm Fixed Priced purchase order. NCI solicited and negotiated directly with Charles River Discovery Research Services UK Limited. The National Cancer Institute (NCI) has a program to use an antibody called, 'A10' to target cancer cells that have a lot of the epidermal growth factor receptor on their cell surface. While this antibody has been extensively tested and characterized it is not known if it also binds any other cell surface proteins. The contractor shall perform an off-target screen on an NCI antibody and report back on any problematic interactions that could predict a serious side effect should the antibody be given to a cancer patient. The A10 is NOT known to bind other cell surface proteins or secreted proteins but this needs to be addressed in the off-target screen.","origin":"extract"},"notice_type":{"code":"a","label":"Award Notice"},"schema_version":1,"solicitation_number":"75N91026P00004","place_of_performance":{"city":{"name":"Saffron"},"state":{"code":"GB-ESS"},"country":{"code":"GBR"}},"product_service_code":"6640"}],"due_at":null,"due_date":null,"closes_at":null,"awardable":false,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7570","sub_name":"OFFICE OF THE ASSISTANT SECRETARY FOR ADMINISTRATION (ASA)","office_key":"o-75P001","office_name":"PROGRAM SUPPORT CENTER ACQ MGMT SVC","state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":"GBR","winner_key":"KWY4CPWDFNT6","amount":"38750.00","linked_awards":1,"cancelled":false,"archived":false,"updated_at":"2026-09-16T21:18:12.857524Z","principal_notice_id":"1f593f2d0a2a4dc6b1e87d1efe846498","description":{"text":"This is a Firm Fixed Priced purchase order. NCI solicited and negotiated directly with Charles River Discovery Research Services UK Limited. The National Cancer Institute (NCI) has a program to use an antibody called, 'A10' to target cancer cells that have a lot of the epidermal growth factor receptor on their cell surface. While this antibody has been extensively tested and characterized it is not known if it also binds any other cell surface proteins. The contractor shall perform an off-target screen on an NCI antibody and report back on any problematic interactions that could predict a serious side effect should the antibody be given to a cancer patient. The A10 is NOT known to bind other cell surface proteins or secreted proteins but this needs to be addressed in the off-target screen.","html":null,"origin":"extract"},"contacts":[{"name":"Elizabeth Bulger","role":"primary","email":"elizabeth.bulger@hhs.gov"}],"place_of_performance":{"city":{"name":"Saffron"},"state":{"code":"GB-ESS"},"country":{"code":"GBR"}},"office_address":{"zip":"20857","city":"ROCKVILLE","state":"MD","country":"USA"},"naics_codes":["541380"],"award":{"date":"2026-01-27","amount":"38750.00","number":"75N91026P00004","awardee":{"raw":"CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED Saffron Walden CB10 1XL GBR","name":"CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED Saffron Walden CB10 1XL GBR"}},"attachments":[],"awards":[{"award_key":"CONT_AWD_75N91026P00004_7529_-NONE-_-NONE-","permalink":"https://www.usaspending.gov/award/CONT_AWD_75N91026P00004_7529_-NONE-_-NONE-/","piid":"75N91026P00004","parent_piid":null,"award_type":"PURCHASE ORDER","vendor_key":"KWY4CPWDFNT6","recipient_name":"CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED","recipient_uei":"KWY4CPWDFNT6","recipient_cage":"U0PH6","recipient_city":"SAFFRON WALDEN","recipient_state":null,"sub_name":"National Institutes of Health","office_name":"NIH NCI","office_key":"o-75N910","first_action_date":"2026-01-27","last_action_date":"2026-01-27","actions":1,"obligated":"38750.00","current_total_value":"38750.00","potential_total_value":"38750.00","naics":"541380","psc":"Q301","extent_competed":"NOT COMPETED","set_aside":"NO SET ASIDE USED.","offers_received":1,"description":"SCREEN THE A10 ANTIBODY FOR OFF-TARGET BINDING TO PLASMA MEMBRANE PROTEINS AND SECRETED PROTEINS.","method":"piid","confidence":"medium","evidence":["award number 75N91026P00004 equals the contract number","awarding office not confirmed"],"opportunity_key":null,"opportunity_title":null}],"related":[{"key":"26SOLIHS1524457","latest_notice_id":"e5f3c5f6c0bf461e82fd1e2480638cad","title":"ScriptPro Upgrade and Maintenance","solicitation_number":"26-SOL-IHS1524457","notice_type":"k","first_type":"k","first_posted":"2026-09-16","last_posted":"2026-09-16","notices":1,"due_at":"2026-09-21T16:00:00Z","due_date":"2026-09-21","closes_at":"2026-09-21T16:00:00Z","awardable":true,"open":true,"dept_key":"d-075","dept_name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF","sub_key":"s-7570","sub_name":"OFFICE OF THE ASSISTANT SECRETARY FOR ADMINISTRATION (ASA)","office_key":"o-75P001","office_name":"PROGRAM SUPPORT CENTER ACQ MGMT SVC","naics":"541519","psc":"7A20","set_aside":null,"state":null,"county":null,"county_name":null,"city":null,"city_name":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-17T06:28:38.602097Z"}]}