# MALDI-TOF Biotyper Sirius

Canonical: https://abierto.us/opportunities/75f40126r00030

- Solicitation number: 75F40126R00030
- Notice type: Combined synopsis and solicitation
- Status: Closed. Deadline was March 10, 2026 at 12:00 PM EDT
- Department: Department of Health and Human Services
- Agency: Food and Drug Administration
- Contracting office: FDA Office of Acq Grant SVCS (75F401)
- NAICS: 334516 Analytical Laboratory Instrument Manufacturing
- Product or service code: 6640 Laboratory Equipment and Supplies
- Place of performance: Summit Argo, Illinois
- County: Cook County (FIPS 17031). https://abierto.us/counties/cook-county-il-17031
- First posted: March 30, 2026
- Last posted: March 30, 2026
- SAM.gov: https://sam.gov/workspace/contract/opp/57fa8276a2354fddb818b0385e04a6ba/view

## Description

The select agent laboratory at Moffett participates in the Laboratory Response Network (LRN) for detecting botulinum neurotoxins (BoNTs). Traditional mouse bioassays, though the gold standard, are costly, slow, and raise ethical concerns. Previously, DIG-ELISA kits were used for high-throughput screening to reduce animal use, but these kits are being phased out in favor of the Endopep-MS (Endopeptidase–Mass Spectrometry) assay.

Developed over 10 years by CDC’s Biological Mass Spectrometry Laboratory, the Endopep-MS assay detects BoNT activity on peptide substrates that mimic the toxin’s natural targets. This method eliminates animal testing and allows high-throughput analysis, supporting rapid response in large-scale events. The FDA requires one (1) Bruker MALDI-TOF Biotyper Sirius one GP system to replace an obsolete instrument.

The system must support Endopep-MS assays for detection, differentiation, and characterization of Clostridium botulinum neurotoxins, maintaining operational capability critical to mission readiness and public health protection.

## Publications

- March 30, 2026: Combined synopsis and solicitation, due March 10, 2026 at 12:00 PM EDT. Notice 57fa8276a2354fddb818b0385e04a6ba. https://sam.gov/workspace/contract/opp/57fa8276a2354fddb818b0385e04a6ba/view

## Points of contact

- Erika Crawford, erika.crawford@fda.hhs.gov, 3017960298

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Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/75f40126r00030.